The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion [PDF]
Cell, 2017 The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells ...
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The Journal of Clinical Investigation, 2022 Dysfunction of protein trafficking has been intensively associated with neurological diseases, including neurodegeneration, but whether and how protein transport contributes to oligodendrocyte (OL) maturation and myelin repair in white matter injury ...
Zhixiong Liu +21 more
doaj +1 more source
Compulsive Social Behavior Emerges after Selective Ablation of Striatal Cholinergic Interneurons [PDF]
, 2017 The mechanisms underlying social dysfunction in neuropsychiatric conditions like obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) remain uncertain. Dysfunctions in basal ganglia, including reduced number of striatal cholinergic interneurons
Beccaria, Juan Pablo +4 more
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Assessing Aβ‐independent effects of Module 42 on immune function in vitro
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION A deep multi‐omic analysis of post mortem human brains has identified a new co‐expression protein network – Module 42 (M42), strongly corelated with Alzheimer's disease (AD) pathology. M42 comprises 32 transmembrane and extracellular matrix (ECM)‐associated proteins, including the amyloid precursor protein (APP) and apolipoprotein
Ishita Ajith +7 more
wiley +1 more source
Retinal stem cells: promising candidates for retina transplantation [PDF]
, 2018 Stem cell transplantation is widely considered as a promising therapeutic approach for photoreceptor degeneration, one of the major causes of blindness.
Arsenijevic, Yvan, Djojosubroto, Meta
core
Pleiotrophin antagonizes Brd2 during neuronal differentiation.
Journal of cell science, 2014 Bromodomain-containing protein 2 (Brd2) is a BET family chromatin adaptor required for expression of cell-cycle-associated genes and therefore involved in cell cycle progression. Brd2 is expressed in proliferating neuronal progenitors, displays cell-cycle-stimulating activity and, when overexpressed, impairs neuronal differentiation.
García-Gutiérrez, Pablo +3 more
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Pleiotrophin Exerts Its Migration and Invasion Effect through the Neuropilin-1 Pathway
Neoplasia: An International Journal for Oncology Research, 2015 Pleiotrophin (PTN) is a pleiotropic growth factor that exhibits angiogenic properties and is involved in tumor growth and metastasis. Although it has been shown that PTN is expressed in tumor cells, few studies have investigated its receptors and their ...
Rania Elahouel +8 more
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Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice [PDF]
, 2016 INTRODUCTION Treatment with estrogen and progesterone (E+P) mimics the protective effect of parity on mammary tumors in rodents and depends upon the activity of p53.
Blackburn, Anneke C +4 more
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9-cis-retinoic acid during in vitro maturation improves development of the bovine oocyte and increases midkine but not IGF-I expression in cumulus-granulosa cells [PDF]
, 2012 The isomer 9-cis of retinoic acid (9-cis-RA) exerts a beneficial effect on bovine in vitro development when added to in vitro maturation (IVM) culture. In the present work, 9-cis-RA 5 nM was found to be stimulatory as opposed to 500 nM (toxic).
Carneiro, Gustavo +9 more
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Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina [PDF]
, 2012 BACKGROUND: Midkine is a small heparin binding growth factor expressed in numerous tissues during development. The unique midkine gene in mammals has two paralogs in zebrafish: midkine-a (mdka) and midkine-b (mdkb).
Anda-Alexandra Calinescu +5 more
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