Results 101 to 110 of about 3,583 (200)

Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: Case-control study

, 2022
Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing.
Nakagawa-Senda, Hiroko, Shimanoe, Chisato, Takezaki, Toshiro, Otonari, Jun, Ozaki, Etsuko, Saita, Kosuke, Tanaka, Keitaro, Ibusuki, Rie, Sudo, Yoshika, Ito, Hidemi, Ikezaki, Hiroaki, Uchida, Kanji, Kita, Yoshikuni, Hishida, Asahi, Katsuura-Kamano, Sakurako, Sumitani, Masahiko, Abe, Hiroaki, Oze, Isao, Nakamura, Yohko, Kusakabe, Miho, Tamura, Takashi, Matsui, Daisuke, Nakamura, Yasuyuki, Arisawa, Kokichi, Suzuki, Sadao, Kuriki, Kiyonori, Nishizawa, Daisuke, Ikeda, Kazutaka, Wakai, Kenji, Takeuchi, Kenji, Momozawa, Yukihide   +30 more
core   +1 more source

Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche

Cell Reports, 2012
The mechanisms through which the bone marrow (BM) microenvironment regulates hematopoietic stem cell (HSC) fate remain incompletely understood. We examined the role of the heparin-binding growth factor pleiotrophin (PTN) in regulating HSC function in the
Heather A. Himburg, Jeffrey R. Harris, Takahiro Ito, Pamela Daher, J. Lauren Russell, Mamle Quarmyne, Phuong L. Doan, Katherine Helms, Mai Nakamura, Emma Fixsen, Gonzalo Herradon, Tannishtha Reya, Nelson J. Chao, Sheila Harroch, John P. Chute   +14 more
doaj   +1 more source

FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin

, 2007
The role of fibroblast growth factors (FGFs) in blood vessel formation has remained unclear. We used differentiating stem-cell cultures (embryoid bodies) and teratomas to show that FGIF receptor-1 (FGFR-1) exerts a negative regulatory effect on ...
Dimberg, Anna,, Mellberg, Sofie,, Claesson-Welsh, Lena,, Magnusson, Peetra U,, Lukinius, Agneta,   +4 more
core   +1 more source

Genetic deletion of pleiotrophin leads to disruption of spinal nociceptive transmission: Evidence for pleiotrophin modulation of morphine-induced analgesia

European Journal of Pharmacology, 2010
Pleiotrophin (PTN) is a growth factor that exhibits neurotrophic actions and is upregulated at sites of nerve injury. Upregulation of PTN levels in injured dorsal root ganglion correlates with decreased mechanical allodynia and faster recovery from Chronic Constriction Injury of the rat sciatic nerve.
Gramage, Esther, Herradón Gil-Gallardo, Gonzalo   +1 more
openaire   +3 more sources

Implications of pleiotrophin in human PC3 prostate cancer cell growth in vivo

, 2012
Pleiotrophin (PTN) is a heparin-binding growth factor with diverse functions related to tumor growth, angiogenesis, and metastasis. Pleiotrophin seems to have a significant role in prostate cancer cell growth and to mediate the stimulatory actions of ...
Hatziapostolou, M., Lamprou, M., Ravazoula, P., Papadimitriou, E., Tsirmoula, S., Dimas, K.   +5 more
core   +1 more source

Alterations of overused supraspinatus tendon: a possible role of glycosaminoglycans and HARP/pleiotrophin in early tendon pathology.

, 2011
Item does not contain fulltextSupraspinatus tendon overuse injuries lead to significant pain and disability in athletes and workers. Despite the prevalence and high social cost of these injuries, the early pathological events are not well known.
Scott, A., José Courty, Courty, J., Tassoni, M.C., Carpentier, G., Isabelle Martelly, Huynh, M.B., Toin H. Van Kuppevelt, Louis J. Soslowsky, Alexander Scott, Martelly, I., Soslowsky, L.J., Kuppevelt, T. van, Gossard, C., Mohamed Attia, Arlette Duchesnay, Marie-Claude Tassoni, Gilles Carpentier, Attia, M., Duchesnay, A., Minh Bao Huynh, Camille Gossard   +21 more
core   +1 more source

Pleiotrophin over-expression rescues dopaminergic neurons in parkinsonian rats

Background: Pleiotrophin is known to promote the survival and differentiation of dopaminergic neurons in vitro and is up-regulated in the substantia nigra of Parkinson's disease patients.
Chertoff, Mariela, Murer, Mario G., Taravini, Irene R. E., Courty, José, Pitossi, Fernando J., Cafferata, Eduardo G., Gershanik, Oscar S.   +6 more
core  

Enhanced antitumorigenic effects in glioblastoma on double targeting of pleiotrophin and its receptor ALK

, 2009
In adults, glioblastomas are the most lethal and most frequent malignant brain tumors, and the poor prognosis despite aggressive treatment indicates the need to establish novel targets for molecular intervention.
Steinberg, Florian, Aigner, Achim, Czubayko, Frank, Florian Steinberg, Tobias Martens, Lamszus, Katrin, Grzelinski, Marius, Achim Aigner, Frank Czubayko, Katrin Lamszus, Martens, Tobias, Marius Grzelinski   +11 more
core   +1 more source

Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus

Neurobiology of Disease
Obesity and metabolic disorders, such as metabolic syndrome (MetS) facilitate the development of neurodegenerative diseases and cognitive decline. Persistent neuroinflammation plays an important role in this process. Pleiotrophin (PTN) is a cytokine that
Héctor Cañeque-Rufo, Teresa Fontán-Baselga, Milagros Galán-Llario, Agata Zuccaro, María Gracia Sánchez-Alonso, Esther Gramage, María del Pilar Ramos-Álvarez, Gonzalo Herradón   +7 more
doaj   +1 more source

Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and white matter development

iScience
Summary: Mutations of TRAPPC12 are associated with progressive childhood encephalopathy including abnormal white matter. However, the underlying pathogenesis is still unclear.
Tiantian Ma, Yaqing Wang, Laikang Yu, Jinghua Liu, Tao Wang, Pengyu Sun, Yinghang Feng, Dan Zhang, Lei Shi, Kangmin He, Li Zhao, Zhiheng Xu   +11 more
doaj   +1 more source