Pleiotrophin Interaction with Synthetic Glycosaminoglycan Mimetics
Pharmaceuticals, 2022 Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo. Some structures of PTN in solution have been solved, but no precise location of the binding site has been reported yet.
Jonathan R. Miles +3 more
doaj +4 more sources
Pleiotrophin Expression and Actions in Pancreatic β-Cells [PDF]
Frontiers in Endocrinology, 2022 Pleiotrophin (PTN) is a heparin-binding cytokine that is widely expressed during early development and increases in maternal circulation during pregnancy.Aged PTN-deficient mice exhibit insulin resistance, suggesting a role in metabolic control.
Julio Sevillano +11 more
doaj +3 more sources
Increased Pleiotrophin Concentrations in Papillary Thyroid Cancer. [PDF]
PLoS ONE, 2016 BACKGROUND:Thyroid nodules are common, and approximately 5% of these nodules are malignant. Pleiotrophin (PTN) is a heparin-binding growth factor which is overexpressed in many cancers.
Youn Hee Jee +9 more
doaj +4 more sources
Behavioral and neuroanatomical abnormalities in pleiotrophin knockout mice. [PDF]
PLoS ONE, 2014 Pleiotrophin (PTN) is an extracellular matrix-associated protein with neurotrophic and neuroprotective effects that is involved in a variety of neurodevelopmental processes.
Jason W Krellman +4 more
doaj +3 more sources
Targeting the PTN/PTPRZ1-ROS Pathway to Promote Bone Regeneration [PDF]
BiomedicinesBackground: Osteoporosis is a global health problem that significantly decreases patients’ quality of life and causes tremendous medical burdens. Therefore, exploring effective targeting strategies for osteoporosis treatment is crucial.
Kai Zhao +6 more
doaj +2 more sources
Beyond Amyloid: Targeting Co-Aggregating Proteins and Targeted Degradation Strategies in Alzheimer’s Disease [PDF]
BiomedicinesAlzheimer’s disease (AD) involves a constellation of molecular processes that extend well beyond amyloid-β (Aβ) accumulation. Recent anti-amyloid antibodies provide limited clinical benefits, highlighting the need for additional strategies due to their ...
Martina Monaco +2 more
doaj +2 more sources
miR-338-3p promotes radiation recall like dermatitis by suppressing pleiotrophin via the PI3K/Akt/Bcl2 pathway [PDF]
Molecular BiomedicineRadiation recall dermatitis (RRD) is a rare but severe inflammatory reaction induced by certain drugs in previously irradiated skin, which can markedly impair quality of life and disrupt cancer treatment.
Yu Min +7 more
doaj +2 more sources
The effects of pleiotrophin in proliferative diabetic retinopathy. [PDF]
PLoS ONE, 2015 Pleiotrophin (PTN), a secreted, multifunctional cytokine, is involved in angiogenic, fibrotic and neurodegenerative diseases. However, little is known about its effects on diabetic retinopathy, a neurovascular disease.
Xuemei Zhu +11 more
doaj +4 more sources
Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation. [PDF]
Glia– CSF2, IL3, and TNFɑ directly promote microglial proliferation. – Neuron‐secreted factors suppress microglial proliferation. – IL1 cytokines promote CSF2 release from astrocytes, which promotes microglial proliferation. ABSTRACT Microglia—the predominant immune cell of the central nervous system (CNS)—possess an astounding capacity for proliferation ...
Hammond BP +4 more
europepmc +2 more sources
Pleiotrophin/Midkine Pathway Is Dysregulated in a TDP-43A315T Mouse Model of Amyotrophic Lateral Sclerosis (ALS). [PDF]
NeuropathologyABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Martínez-Alesón P +3 more
europepmc +2 more sources