Results 11 to 20 of about 3,583 (200)
Behavioral and neuroanatomical abnormalities in pleiotrophin knockout mice. [PDF]
PLoS ONE, 2014 Pleiotrophin (PTN) is an extracellular matrix-associated protein with neurotrophic and neuroprotective effects that is involved in a variety of neurodevelopmental processes.
Jason W Krellman +4 more
doaj +5 more sources
Expression analysis of macrodactyly identifies pleiotrophin upregulation. [PDF]
PLoS ONE, 2012 Macrodactyly is a rare family of congenital disorders characterized by the diffuse enlargement of 1 or more digits. Multiple tissue types within the affected digits are involved, but skeletal patterning and gross morphological features are preserved. Not
Frank H Lau +7 more
doaj +8 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on PTN (pleiotrophin), with data on DNA, on the protein encoded, and where the gene is implicated.
Pantazaka, E, Papadimitriou, E
openaire +3 more sources
Pleiotrophin over-expression provides trophic support to dopaminergic neurons in parkinsonian rats [PDF]
Molecular Neurodegeneration, 2011 Background Pleiotrophin is known to promote the survival and differentiation of dopaminergic neurons in vitro and is up-regulated in the substantia nigra of Parkinson's disease patients.
Pitossi Fernando J +6 more
doaj +2 more sources
A Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ
Molecular Cancer, 2010 Background Pleiotrophin, also known as HARP (Heparin Affin Regulatory Peptide) is a growth factor expressed in various tissues and cell lines. Pleiotrophin participates in multiple biological actions including the induction of cellular proliferation ...
Diamantopoulou Zoi +6 more
doaj +2 more sources
Pleiotrophin is a driver of vascular abnormalization in glioblastoma [PDF]
Molecular & Cellular Oncology, 2016 In a recent report by Zhang et al., pleiotrophin (PTN) was demonstrated to enhance glioma growth by promoting vascular abnormalization. PTN stimulates glioma vessels through anaplastic lymphoma kinase (Alk)-mediated perivascular deposition of vascular endothelial growth factor (VEGF).
Lei, Zhang, Anna, Dimberg
openaire +3 more sources
Pleiotrophin Interaction with Synthetic Glycosaminoglycan Mimetics
Pharmaceuticals, 2022 Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo. Some structures of PTN in solution have been solved, but no precise location of the binding site has been reported yet.
Jonathan R. Miles +3 more
doaj +4 more sources
Pleiotrophin Expression and Actions in Pancreatic β-Cells [PDF]
Frontiers in Endocrinology, 2022 Pleiotrophin (PTN) is a heparin-binding cytokine that is widely expressed during early development and increases in maternal circulation during pregnancy.Aged PTN-deficient mice exhibit insulin resistance, suggesting a role in metabolic control.
Julio Sevillano +11 more
doaj +3 more sources
Interactions of Pleiotrophin with a Structurally Defined Heparin Hexasaccharide [PDF]
Biomolecules, 2021 Pleiotrophin (PTN) is a potent cytokine that plays an important role in neural generation, angiogenesis, inflammation, and cancers. Its interactions with the polysaccharide glycosaminoglycan (GAG) are crucial to PTN’s biological activities. In this study,
Eathen O. Ryan +3 more
doaj +3 more sources
New connections: Pleiotrophin and glioma
Science Signaling, 2017 The cytokine pleiotrophin promotes the invasion and vascularization of glioma.
Wei Wong
openaire +2 more sources