Results 31 to 40 of about 4,425 (166)

Therapeutic potential of midkine in cardiovascular disease [PDF]

, 2018
Ischaemic heart disease, stroke and their pathological consequences are life-threatening conditions that account for about half of deaths in developed countries.
Görbe, Anikó, Bencsik, Péter, Kadomatsu K, Kishida S, Sakamoto K, Ferdinandy, Péter, Kadomatsu, Kenji, Csonka, Csaba   +7 more
core   +1 more source

Midkine-a functions as a universal regulator of proliferation during epimorphic regeneration in adult zebrafish.

PLoS ONE, 2020
Zebrafish have the ability to regenerate damaged cells and tissues by activating quiescent stem and progenitor cells or reprogramming differentiated cells into regeneration-competent precursors.
Nicholas B Ang, Alfonso Saera-Vila, Caroline Walsh, Peter F Hitchcock, Alon Kahana, Ryan Thummel, Mikiko Nagashima   +6 more
doaj   +1 more source

Clinical relevance of circulating midkine in ulcerative colitis [PDF]

, 2009
Background: Non-invasive biochemical markers are needed to support the diagnosis of ulcerative colitis (UC), an incurable disease of unknown pathology. Midkine is an angiogenic cytokine, chemotactic towards neutrophils and macrophages, and a T-regulatory
Krzystek-Korpacka, Malgorzata, Neubauer, Katarzyna, Matusiewicz, Malgorzata   +2 more
core   +1 more source

MPA Modulates Tight Junctions' Permeability via Midkine/PI3K Pathway in Caco-2 Cells: A Possible Mechanism of Leak-Flux Diarrhea in Organ Transplanted Patients

Frontiers in Physiology, 2017
Mycophenolic acid (MPA) is prescribed to prevent allograft rejection in organ transplanted patients. However, its use is sporadically linked to leak flux diarrhea and other gastrointestinal (GI) disturbances in around 75% of patients through yet unknown ...
Niamat Khan, Niamat Khan, Lutz Binder, Lutz Binder, D. V. Krishna Pantakani, D. V. Krishna Pantakani, Abdul R. Asif, Abdul R. Asif   +7 more
doaj   +1 more source

Sitagliptin Modulates Oxidative, Nitrative and Halogenative Stress and Inflammatory Response in Rat Model of Hepatic Ischemia-Reperfusion

Antioxidants, 2021
A possibility of repurposing sitagliptin, a well-established antidiabetic drug, for alleviating injury caused by ischemia-reperfusion (IR) is being researched.
Małgorzata Trocha, Mariusz G. Fleszar, Paulina Fortuna, Łukasz Lewandowski, Kinga Gostomska-Pampuch, Tomasz Sozański, Anna Merwid-Ląd, Małgorzata Krzystek-Korpacka   +7 more
doaj   +1 more source

Multiple cis-regulatory elements collaborate to control mdka expression in telencephalic neural stem cells of adult zebrafish during constitutive and regenerative neurogenesis. [PDF]

FEBS J
midkine‐a (mdka), a pan‐injury response gene in vertebrates, is precisely regulated in the zebrafish telencephalon by a modular cis‐regulatory architecture. This control ensures proper expression during development, adult brain homeostasis, and regeneration.
Chen J, Takamiya M, Hendriks A, Beil T, Várnai C, Diotel N, Rastegar S.   +6 more
europepmc   +2 more sources

New molecular mediators in tumor angiogenesis

, 2007
Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Jonas, Dietger, Beecken, Wolf-Dietrich, Kramer, Wolfgang   +2 more
core   +1 more source

Small Molecule BRD4 Inhibitors Apabetalone and JQ1 Rescues Endothelial Cells Dysfunction, Protects Monolayer Integrity and Reduces Midkine Expression

Molecules, 2022
NF-κB signaling is a key regulator of inflammation and atherosclerosis. NF-κB cooperates with bromodomain-containing protein 4 (BRD4), a transcriptional and epigenetic regulator, in endothelial inflammation.
Sidra Shahid, Marlena Pantakani, Lutz Binder, Andreas Fischer, Krishna Pantakani, Abdul R. Asif   +5 more
doaj   +1 more source

Nuclear Targeting by the Growth Factor Midkine

, 2002
Ligand-receptor internalization has been traditionally regarded as part of the cellular desensitization system. Low-density lipoprotein receptor-related protein (LRP) is a large endocytosis receptor with a diverse array of ligands.
McCormick, Lynn M., M. Hirai, Kimura, Terutoshi, T. Muramatsu, Inui, Tatsuya, T. Inui, H. Saito, L. M. McCormick, G. Bu, T. Kimura, K. Kadomatsu, Bu, Guojun, Muramatsu, Takashi, Saito, Hidehiko, Kadomatsu, Kenji, Y. Shibata, Shibata, Yoshihisa, Hirai, Makoto   +17 more
core   +1 more source

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer-6

, 2011
Sion of midkine protein, whereas BxPC-3, HPAC, and Suit-2 cells showed moderate expression. In contrast, expression by PANC-1 cells was low and MIAPaCa-2 cells showed no detectable midkine band.
Tatsuo Ito (95905), Toshihiko Masui (95906), Shinji Uemoto (95909), Kazuyuki Nagai (95904), Ryuichiro Doi (95898), Tomohiko Mori (95900), Masayuki Koizumi (95902), Daisuke Ito (95901), Kazuhiro Kami (95899), Eiji Toyoda (95897), Atsushi Kida (95903), Masatoshi Tagawa (95908), Michihiko Wada (95907)   +12 more
core   +1 more source