Results 11 to 20 of about 4,425 (166)

Midkine is a NF-κB-inducible gene that supports prostate cancer cell survival [PDF]

BMC Medical Genomics, 2008
Background Midkine is a heparin-binding growth factor that is over-expressed in various human cancers and plays important roles in cell transformation, growth, survival, migration, and angiogenesis. However, little is known about the upstream factors and
You Zongbing, Dong Ying, Kong Xiangtian, Beckett Laurel A, Gandour-Edwards Regina, Melamed Jonathan   +5 more
doaj   +3 more sources

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2008
Background To develop a novel therapeutic strategy for human pancreatic cancer using a midkine promoter-based conditionally replicating adenovirus. Methods We examined midkine mRNA expression and midkine protein expression by seven human pancreatic ...
Ito Tatsuo, Nagai Kazuyuki, Kida Atsushi, Koizumi Masayuki, Ito Daisuke, Mori Tomohiko, Kami Kazuhiro, Doi Ryuichiro, Toyoda Eiji, Masui Toshihiko, Wada Michihiko, Tagawa Masatoshi, Uemoto Shinji   +12 more
doaj   +2 more sources

Midkine Is Elevated After Multiple Trauma and Acts Directly on Human Cardiomyocytes by Altering Their Functionality and Metabolism [PDF]

Frontiers in Immunology, 2019
Background and Purpose: Post-traumatic cardiac dysfunction often occurs in multiply injured patients (ISS ≥ 16). Next to direct cardiac injury, post-traumatic cardiac dysfunction is mostly induced by the release of inflammatory biomarkers.
Ina Lackner, Birte Weber, Meike Baur, Melanie Haffner-Luntzer, Tim Eiseler, Giorgio Fois, Florian Gebhard, Borna Relja, Ingo Marzi, Roman Pfeifer, Sascha Halvachizadeh, Miriam Lipiski, Nikola Cesarovic, Hans-Christoph Pape, Miriam Kalbitz, TREAT Research Group   +15 more
doaj   +2 more sources

Midkine: Utility as a Predictor of Early Diabetic Nephropathy in Children with Type 1 Diabetes Mellitus [PDF]

JCRPE, 2021
Objective:This study aimed to assess the role of serum midkine (MK) as a biomarker for early detection of diabetic nephropathy in children with type 1 diabetes mellitus (T1DM) before microalbuminuria emerges.Methods:A total of 120 children with T1DM ...
Kotb Abbass Metwalley, Hekma Saad Farghaly, Magda Farghali Gabri, Safwat Mohamed Abdel-Aziz, Asmaa Mohamed Ismail, Duaa Mohamed Raafat, Islam Fathy Elnakeeb   +6 more
doaj   +2 more sources

Evaluation of Cognitive Functions in Hypertensive Patients and Its Relationship with Serum Midkine Levels [PDF]

Sakarya Tıp Dergisi, 2017
Objective: Hypertension (HT) is one of the risk factors associated with dementia. Our aim was to research cognitive functions in patients with HT and its relationship to midkine levels in serum.
Eda Celik Guzel, Fatma Behice Serinkan Cinemre, Savas Guzel, Volkan Kuçukyalcin, Ali Riza Kiziler, Coskun Cavusoglu, Tevfik Gulyasar, Hakan Cinemre, Birsen Aydemir   +8 more
doaj   +2 more sources

Heparan Sulphate Glycosaminoglycan Chains Contribute to the Tethering of Coronal Factors and Are Important for Extracellular Vesicle-Mediated Fibroblast Activation. [PDF]

J Extracell Biol
ABSTRACT Extracellular vesicles (EVs) play a critical role in intercellular communication, yet the contribution of the EV corona and associated surface structures, such as heparan sulphate glycosaminoglycan (HS GAG) chains, to EV function remains poorly understood.
Veiga S, Shephard AP, Milward K, Cocks A, Royo F, Falcon-Perez JM, Clayton A, Webber JP.   +7 more
europepmc   +2 more sources

Midkine ameliorates LPS-induced apoptosis of airway smooth muscle cells via the Notch2 pathway

Asian Pacific Journal of Tropical Biomedicine, 2022
Objective: To evaluate the effect of midkine on lipopolysaccharide (LPS)-induced airway smooth muscle cells (ASMCs). Methods: LPS-stimulated acute lung injury model was used to analyze the effect of midkine on ASMCs in vitro.
Qi-Feng Huang, Bo Wang, Yu-Qing Weng, Tang Deng, Li-Hua Li, Jin Qian, Qi Li, Kai-Wen Lin, Dong-Mei Sun, Shuang-Qin Xu, Hang-Fei Wang, Xin-Xin Wu, Yuan-Tian Sun, Xiao-Ran Liu   +13 more
doaj   +1 more source

Pulmonary midkine inhibition ameliorates sepsis induced lung injury

Journal of Translational Medicine, 2021
Background Midkine is a multi-functional molecule participating in a various key pathological process. We aimed to evaluate the change of midkine in sepsis and its association with angiotensin-converting enzyme (ACE) system, as well as the mechanism by ...
Jing-Yuan Xu, Wei Chang, Qin Sun, Fei Peng, Yi Yang   +4 more
doaj   +1 more source

Midkine inhibition enhances anti-PD-1 immunotherapy in sorafenib-treated hepatocellular carcinoma via preventing immunosuppressive MDSCs infiltration

Cell Death Discovery, 2023
Sorafenib, a multiple-target tyrosine kinase inhibitor, is the standard of care for patients with advanced hepatocellular carcinoma (HCC), but provides limited benefits.
Lijuan Ding, Nanya Wang, Qiang Wang, Xia Fan, Yuning Xin, Shudong Wang   +5 more
doaj   +1 more source

Midkine Overexpression Promotes Functional Recovery After Spinal Cord Injury by Enhancing Microglial Efferocytosis Via LRP-1. [PDF]

CNS Neurosci Ther
Midkine (MDK) promotes functional recovery after spinal cord injury by enhancing microglial efferocytosis, reducing neuroinflammation, and decreasing neuronal apoptosis. Overexpression of MDK activates the AKT/mTOR pathway, upregulates LRP‐1 and BDNF, and drives microglia toward an anti‐inflammatory phenotype.
Wang Y, Fang L, Zhai C, Cai J, Li X, Zong L, Geng Y, Zhu C, Sun C, Dong M, Qian Y, Liu Y, Huang Y, Wang Z, Wang T, Liu WT, Wu Q.   +16 more
europepmc   +2 more sources