Results 41 to 50 of about 4,425 (166)

Biomarkers for Detecting Kidney Dysfunction in Type-2 Diabetics and Diabetic Nephropathy Subjects: A Case-Control Study to Identify Potential Biomarkers of DN to Stratify Risk of Progression in T2D Patients

Frontiers in Endocrinology, 2022
IntroductionCurrently there are no biomarkers that are predictive of when patients with type-2 diabetes (T2D) will progress to more serious kidney disease i.e., diabetic nephropathy (DN).
Carla Harkin, Diego Cobice, Simon Brockbank, Stephanie Bolton, Frances Johnston, Anna Strzelecka, Joanne Watt, Mary Jo Kurth, John V. Lamont, Peter Fitzgerald, Tara Moore, Mark W. Ruddock   +11 more
doaj   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer-0

, 2011
Sion of midkine protein, whereas BxPC-3, HPAC, and Suit-2 cells showed moderate expression. In contrast, expression by PANC-1 cells was low and MIAPaCa-2 cells showed no detectable midkine band.
Tatsuo Ito (95905), Toshihiko Masui (95906), Shinji Uemoto (95909), Kazuyuki Nagai (95904), Ryuichiro Doi (95898), Tomohiko Mori (95900), Masayuki Koizumi (95902), Daisuke Ito (95901), Kazuhiro Kami (95899), Eiji Toyoda (95897), Atsushi Kida (95903), Masatoshi Tagawa (95908), Michihiko Wada (95907)   +12 more
core   +1 more source

Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina

Neural Development, 2012
Background Midkine is a small heparin binding growth factor expressed in numerous tissues during development. The unique midkine gene in mammals has two paralogs in zebrafish: midkine-a (mdka) and midkine-b (mdkb).
Luo Jing, Uribe Rosa A, Hayton Sarah, Calinescu Anda-Alexandra, Gross Jeffrey M, Hitchcock Peter F   +5 more
doaj   +1 more source

Physiology of Midkine and Its Potential Pathophysiological Role in COVID-19

Frontiers in Physiology, 2020
SARS-CoV2 infection not only causes abnormal severe pneumonia but also induces other relevant pathophysiological effects on several tissues and organs.
Giulia Sanino, Martino Bosco, Giuseppe Terrazzano, Giuseppe Terrazzano   +3 more
doaj   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Relationship between serum Midkine and Omentin-1 levels and the severity of sepsis in patients and their prognostic value

Libyan Journal of Medicine
To explore the relationship between serum levels of midkine and omentin-1 and the severity of sepsis in patients, and their prognostic value. A retrospective analysis was conducted on the clinical data of 180 sepsis patients. According to the severity of
Lin Gao, Qindi Liu, Zhiming Kuang, Shanbin Yuan   +3 more
doaj   +1 more source

Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro‐Ecological Perspective

Advanced Science, EarlyView.
This review reframes perineural invasion (PNI) as a dynamic, multicellular process within the tumor–nerve–stromal ecosystem. The authors delineate how cancer‐associated fibroblasts, Schwann cells, and immune cells remodel the neural niche to facilitate tumor spread.
Xiaoyang Lin, Yingqiao Liu, Haitao Lin, Kang Feng, Xiqiang Liu   +4 more
wiley   +1 more source

Immunhistologische Untersuchungen zur Frakturheilung Midkine-defizienter Mäuse

, 2018
Die Versorgung von Frakturen in der Medizin hat sich in den letzten Jahren stetig verbessert. Dennoch sind orthopädische Komplikationen, wie z.B.
Beie, Simon Thomas
core   +1 more source

Midkine and chronic kidney disease-associated multisystem organ dysfunctions

, 2021
Chronic kidney disease (CKD) is a progressive multisystem condition with yet undefined mechanistic drivers and multiple implicated soluble factors. If identified, these factors could be targeted for therapeutic intervention for a disease that currently ...
Burg, D, Robertson, GR, Gray, NA, Gately, RP, Campbell, VK, Krishnasamy, R   +5 more
core   +1 more source