Results 61 to 70 of about 7,018 (211)

Systemic inflammation, nutritional status and survival in patients with cancer [PDF]

, 2009
Systemic inflammation, nutritional status and survival in patients with ...
Al Murri, Brown, Cho, Crumley, Crumley, Crumley, Fearon, Forrest, Forrest, Gabay, Glen, Gomez, Gridelli, Halazun, Hara, Hilmy, Ishizuka, Jamieson, Karakiewicz, Kerem, Kobayashi, Krzystek-Korpacka, Leitch, Malik, Marsik, McMillan, McMillan, Morley, Ramsey, Read, Sharma, Sharma, Walsh, Yamanaka   +33 more
core   +1 more source

Comprehensive analysis and functional validation of key genes in bladder cancer progression

VIEW, EarlyView.
Bladder cancer is highly diverse between patients, making it difficult to accurately predict who will have aggressive disease and poor outcomes. In this study, we integrated single‐cell RNA sequencing with clinical survival data to identify a simple three‐gene signature (FAM3B, C10orf99, and VMP1) that stratifies patients into high‐ and low‐risk groups.
Xiaoning Cheng, Hongxia Zhao, Qian Li, Boyang Liu, Maoping Cai, Xinyi Wang, Jiancong Lie, Yuanyuan Qu, Jianwei Li, Chunlong Yang   +9 more
wiley   +1 more source

Midkine—A novel player in cardiovascular diseases

Frontiers in Cardiovascular Medicine, 2022
Midkine (MK) is a 13-kDa heparin-binding cytokine and growth factor with anti-apoptotic, pro-angiogenic, pro-inflammatory and anti-infective functions, that enable it to partake in a series of physiological and pathophysiological processes. In the past, research revolving around MK has concentrated on its roles in reproduction and development, tissue ...
Marina Majaj, Marina Majaj, Ludwig T. Weckbach, Ludwig T. Weckbach, Ludwig T. Weckbach   +4 more
openaire   +4 more sources

Relationship between serum Midkine and Omentin-1 levels and the severity of sepsis in patients and their prognostic value

Libyan Journal of Medicine
To explore the relationship between serum levels of midkine and omentin-1 and the severity of sepsis in patients, and their prognostic value. A retrospective analysis was conducted on the clinical data of 180 sepsis patients. According to the severity of
Lin Gao, Qindi Liu, Zhiming Kuang, Shanbin Yuan   +3 more
doaj   +1 more source

Small Molecule BRD4 Inhibitors Apabetalone and JQ1 Rescues Endothelial Cells Dysfunction, Protects Monolayer Integrity and Reduces Midkine Expression

Molecules, 2022
NF-κB signaling is a key regulator of inflammation and atherosclerosis. NF-κB cooperates with bromodomain-containing protein 4 (BRD4), a transcriptional and epigenetic regulator, in endothelial inflammation.
Sidra Shahid, Marlena Pantakani, Lutz Binder, Andreas Fischer, Krishna Pantakani, Abdul R. Asif   +5 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

ALK activation, ligands and therapeutic targets in glioblastoma and other cancers

Frontiers in Oncology, 2012
The intracellular anaplastic lymphoma kinase (ALK) fragment shows striking homology with members of the insulin receptor family and was initially identified as an oncogenic fusion protein resulting from a translocation in lymphoma and more recently in a ...
Anton eWellstein
doaj   +1 more source

Midkine: Utility as a Predictor of Early Diabetic Nephropathy in Children with Type 1 Diabetes Mellitus

JCRPE, 2021
Objective:This study aimed to assess the role of serum midkine (MK) as a biomarker for early detection of diabetic nephropathy in children with type 1 diabetes mellitus (T1DM) before microalbuminuria emerges.Methods:A total of 120 children with T1DM ...
Kotb Abbass Metwalley, Hekma Saad Farghaly, Magda Farghali Gabri, Safwat Mohamed Abdel-Aziz, Asmaa Mohamed Ismail, Duaa Mohamed Raafat, Islam Fathy Elnakeeb   +6 more
doaj   +1 more source

Biomarkers for Hepatocellular Carcinoma [PDF]

, 2017
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. The HCC diagnosis is usually achieved by biomarkers, which can also help in prognosis prediction.
Jiang, Shuai, Lou, Jiatao, Lv, Shaogang, Zhang, Chenzi, Zhang, LingFei   +4 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, Volume 16, Issue 5, Page 1000-1019, May 2026.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source