Results 61 to 70 of about 4,425 (166)

Analysis of Urinary Midkine and Volatile Organic Compound (VOC) Levels Using a Breath Analyzer for Screening and Early Diagnosis of Lung Cancer

Jurnal Respirasi
Introduction: Lung cancer is the leading cause of cancer-related mortality worldwide. Midkine, a heparin-binding growth factor, promotes proliferation, angiogenesis, and metastasis. Volatile organic compounds (VOCs) reflect cellular and molecular changes,
Saidah Mafisah, Ungky Agus Setyawan, Rezki Tantular, Deden Permana, Susanthy Djajalaksana, Arinto Yudi Ponco Wardoyo, Aditya Sri Listyoko   +6 more
doaj   +1 more source

Midkine: The Who, What, Where, and When of a Promising Neurotrophic Therapy for Perinatal Brain Injury

Frontiers in Neurology, 2020
Midkine (MK) is a small secreted heparin-binding protein highly expressed during embryonic/fetal development which, through interactions with multiple cell surface receptors promotes growth through effects on cell proliferation, migration, and ...
Emily Ross-Munro, Faith Kwa, Faith Kwa, Jenny Kreiner, Madhavi Khore, Suzanne L. Miller, Mary Tolcos, Bobbi Fleiss, Bobbi Fleiss, David W. Walker   +9 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion

, 2005
Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion.BackgroundMidkine, a heparin-binding growth factor, is involved in the migration of inflammatory cells.
Matsuo, Seiichi, Muramatsu, Takashi, Kadomatsu, Kenji, Takei, Yoshifumi, Sato, Waichi, Yuzawa, Yukio   +5 more
core   +1 more source

Antibody Characterization Report for Midkine

, 2021
Head-to-head comparison of available commercial antibodies against Midkine by immunoblot (Western blot) and immunoprecipitation on total cell lysates and conditioned media.
Ayoubi, Riham, McPherson, Peter S., Laflamme, Carl   +2 more
core   +1 more source

Comprehensive analysis and functional validation of key genes in bladder cancer progression

VIEW, Volume 7, Issue 3, June 2026.
Bladder cancer is highly diverse between patients, making it difficult to accurately predict who will have aggressive disease and poor outcomes. In this study, we integrated single‐cell RNA sequencing with clinical survival data to identify a simple three‐gene signature (FAM3B, C10orf99, and VMP1) that stratifies patients into high‐ and low‐risk groups.
Xiaoning Cheng, Hongxia Zhao, Qian Li, Boyang Liu, Maoping Cai, Xinyi Wang, Jiancong Lie, Yuanyuan Qu, Jianwei Li, Chunlong Yang   +9 more
wiley   +1 more source

Midkine in Host Defense.

, 2014
Midkine shares several features in common with antibacterial proteins of the innate immune system. These include growth factor properties, heparin-binding regions, and effects on immune cells (i.e.
Egesten, Arne,, Gela, Anele, Nordin, Sara, Egesten, Arne, Jovic, Sandra,, Nordin, Sara,, Lund University., Jovic, Sandra, Gela, Anele,   +8 more
core   +1 more source

Multi‐Omics Integration Reveals Incomplete Reactivation of Developmental Cell‐Cycle Programs in Adult Human Infarcted Hearts

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Cross‐context integration of single‐nucleus, spatial, bulk transcriptomic, and chromatin accessibility data from human fetal and adult infarcted hearts reveals that infarct‐zone cardiomyocytes re‐enter the cell cycle but show insufficient reactivation of late mitotic and cytokinesis execution programs, suggesting that incomplete cytokinesis ...
Jieran Lyu, Yuki Kuramoto, Jun Li, Jong‐Kook Lee, Kyoko Hidaka, Yasushi Sakata   +5 more
wiley   +1 more source

Extracellular vesicles derived from pancreatic cancer cells are enriched in the growth factor Midkine

, 2022
The growth factor Midkine is a heparin-binding cytokine originally discovered during the differentiation process induced by the retinoic acid in embryonal carcinoma cells. Several studies pointed out the key role of this protein in tumour progression and
Emmanouilidi A., Domenichini A., Casari I., Falasca M.   +3 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, Volume 16, Issue 5, Page 1000-1019, May 2026.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source