Results 81 to 90 of about 4,425 (166)

DSG2+ Cancer Stem Cells Co‐Located With FAP+ Myofibroblasts in the Tumor Boundary That Determines the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Cancer stem cells (CSCs) in non‐small cell lung cancer display pronounced plasticity and spatial heterogeneity. By integrating single‐cell and spatial transcriptomics, this study defines a DSG2‐associated CSC program and reveals a tumor‐margin niche formed with FAP+ myofibroblasts.
Guangyu Fan, Le Tang, Tongji Xie, Mengwei Yang, Lin Li, Sheng Yang, Puyuan Xing, Xiaohong Han, Yuankai Shi   +8 more
wiley   +1 more source

Effects of Tumor Microenvironment on Lung Cancer Stem Cells: Bidirectional Regulatory Mechanisms

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Lung cancer, with a high mortality rate, poses challenges in treatment due to its invasiveness and heterogeneity. Lung cancer stem cells (LCSCs) are considered key contributors to recurrence and metastasis because of their self‐renewal, pluripotency, and drug resistance.
Hongyi Lai, Ruihang Luo, Wei Zou, Xuyang Liu, Maosen Liu, Mingshan Liu, Jingtao Zhang   +6 more
wiley   +1 more source

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer-5

, 2011
L of PBS, was administered intraperitoneally. There was a significant difference of survival time between the Ad5MK group and the other groups (p = 0.0002 Log-rank test and p = 0.0002 by Wilcoxson's test).Copyright information:Taken from "Midkine ...
Tatsuo Ito (95905), Toshihiko Masui (95906), Shinji Uemoto (95909), Kazuyuki Nagai (95904), Ryuichiro Doi (95898), Tomohiko Mori (95900), Masayuki Koizumi (95902), Daisuke Ito (95901), Kazuhiro Kami (95899), Eiji Toyoda (95897), Atsushi Kida (95903), Masatoshi Tagawa (95908), Michihiko Wada (95907)   +12 more
core   +1 more source

Electroacupuncture Modulates Multiple Pathways for Neuroprotection and Neurorepair in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
EA exerts therapeutic effects in ischemic stroke through multiple mechanisms: it alleviates acute injury by suppressing neuroinflammation, excitotoxicity, oxidative stress, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and blood–brain barrier disruption, while enhancing cerebral blood flow, angiogenesis, and neurogenesis to support ...
Mingyue Zhao, Hangyu Shen, Xu Yan, Xiang Gao, Yuchun Liu, Shengjun Zhou, Jingxian Sun, Jie Sun, Yi Huang   +8 more
wiley   +1 more source

Diagnostic accuracy of midkine for hepatocellular carcinoma: A meta‐analysis

Molecular Genetics & Genomic Medicine, 2020
Background There have been many reports on midkine as a promising marker in the diagnosis of hepatocellular carcinoma (HCC). However, the results are inconsistent and even conflicting.
Yu Zhang, Juan Tang, Xiao Zhou, Shao‐Liang Zhu, Le‐Qun Li   +4 more
doaj   +1 more source

Midkine is a dual regulator of wound epidermis development and inflammation during the initiation of limb regeneration

eLife, 2020
Formation of a specialized wound epidermis is required to initiate salamander limb regeneration. Yet little is known about the roles of the early wound epidermis during the initiation of regeneration and the mechanisms governing its development into the ...
Stephanie L Tsai, Clara Baselga-Garriga, Douglas A Melton   +2 more
doaj   +1 more source

Midkine is expressed by infiltrating macrophages in in-stent restenosis in hypercholesterolemic rabbits

, 2008
BackgroundNeointimal hyperplasia is strikingly suppressed in an endothelium injury model in mice deficient in the growth factor midkine. Knockdown of midkine expression by means of antisense oligonucleotide or small interfering RNA has been shown to lead
Kenji Kadomatsu, Chen, Sen, Narita, Hiroshi, Hiroshi Narita, Kadomatsu, Kenji, Kimihiro Komori, Komori, Kimihiro, Sen Chen   +7 more
core   +1 more source

Association Midkine in plasma as a novel breast cancer marker

, 2020
Midkine, a heparin-binding growth factor, is up-regulated in many types of cancer. The aim of this study was to measure plasma midkine levels in patients with breast cancer and to assess its clinical significance.
Yutaka Yamamoto, Mitsuharu Ueda, Satoru Shinriki, Masanori Shinohara, Yukio Ando, Kazutoshi Ota, Sadatoshi Sakuma, Hirotaka Iwase, Hiromi Fujimori, Mutsuko Ibusuki, Asia, Masahiro Taketomi, Blackwell Publishing   +12 more
core  

A single intracoronary injection of midkine reduces ischemia/reperfusion injury in swine hearts: a novel therapeutic approach for acute coronary syndrome

Frontiers in Physiology, 2011
Several growth factors are effective for salvaging myocardium and limiting infarct size in experimental studies with small animals. Their benefit in large animals and feasibility in clinical practice remains to be elucidated.
Hisaaki eIshiguro, Hisaaki eIshiguro, Mitsuru eHoriba, Mitsuru eHoriba, Hiroharu eTakenaka, Arihiro eSumida, Tobias Opthof, Yuko S Ishiguro, Kenji eKadomatsu, Kenji eKadomatsu, Toyoaki eMurohara, Itsuo eKodama   +11 more
doaj   +1 more source

Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine

, 2017
Cutaneous melanoma is a type of cancer with an inherent potential for lymph node colonization, which is generally preceded by neolymphangiogenesis. However, sentinel lymph node removal does not necessarily extend the overall survival of patients with ...
Rodríguez Peralto, José Luis, Riveiro Falkenbach, Erica, Ortiz Romero, Pablo Luis, Soengas, María S., Lora Pablos, David, Olmeda, David   +5 more
core   +1 more source