Results 91 to 100 of about 4,425 (166)

High Expression of Midkine in the Airways of Patients with Cystic Fibrosis

, 2013
Mutations in the CFTR gene result in impaired host defense during cystic fibrosis (CF), where Pseudomonas aeruginosa becomes a key pathogen. We investigated the expression pattern of the antibacterial growth factor midkine in CF and possible interference
Kurut Sabanoglu, Anil,, Lund, Mikael,, Egesten, Arne,, Andersson, Cecilia,, Bjartell, Anders,, Olin, Anders,, Jovic, Sandra,, Nordin, Sara,, Mörgelin, Matthias,, Lund University., Gela, Anele,   +10 more
core   +2 more sources

Midkine-antibody (Mdk-Ab) treatment accelerated osteoporotic fracture healing.

, 2016
Biomechanical, micro-computed tomography (μCT) and histomorphometric analysis of the fractured femurs at day 23. Biomechanical testing: A) relative flexural rigidity of the fractured femur in comparison with intact femur determined by biomechanical ...
Katja Prystaz (3154410), Julia Kemmler (765385), Verena Heidler (3154404), Anita Ignatius (142960), Astrid Liedert (504726), Michael Amling (133377), Anna Kovtun (3154407), Anna E. Rapp (2158540), Thorsten Schinke (126724), Melanie Haffner-Luntzer (504724)   +9 more
core   +1 more source

The Role of Midkine in Arteriogenesis, Involving Mechanosensing, Endothelial Cell Proliferation, and Vasodilation [PDF]

, 2018
Mechanical forces in blood circulation such as shear stress play a predominant role in many physiological and pathophysiological processes related to vascular responses or vessel remodeling.
Deindl, Elisabeth, Weckbach, Ludwig T., Ludwig Weckbach, Preissner, Klaus T., Klaus Preissner, Elisabeth Deindl   +5 more
core   +1 more source

Ethanol-induced changes in neurotrophic and immune genes are regulated by receptor-type protein tyrosine phosphatase β/ζ (RPTPβ/ζ) and microglial-neuronal interactions

Frontiers in Genetics
Microglial cells are key mediators of ethanol-induced neuroinflammation through the release of proinflammatory cytokines and activation of Toll-like receptors.
María Aránzazu Penedo, María Aránzazu Penedo, Héctor Cañeque-Rufo, Héctor Cañeque-Rufo, Esther Gramage, Esther Gramage, Esther Gramage, Gonzalo Herradón, Gonzalo Herradón, Gonzalo Herradón   +9 more
doaj   +1 more source

Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death

, 2011
Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, promotes cancer cell death via autophagy stimulation. We find that activation of the tyrosine kinase receptor ALK by its ligand midkine interferes with the signaling mechanism by ...
Sonia Hernández-Tiedra, Carracedo, Arkaitz, Campos Martín, Yolanda, Hernández Tiedra, Sonia, Manuel Guzmán, Mollejo, Manuela, Salazar Roa, María, Torres, Sofia, Mar Lorente, Arkaitz Carracedo, Fátima Rodríguez-Fornés, Guillermo Velasco, Lorente Pérez, María Del Mar, Juan A. Barcia, Manuela Mollejo, Elena García-Taboada, García Taboada, Elena, Velasco Díez, Guillermo, Meléndez, Bárbara, Guzmán Pastor, Manuel, Yolanda Campos-Martín, Rodríguez Fornés, Fátima, Bárbara Meléndez, Barcia Albacar, Juan Antonio, María Salazar, Sofia Torres   +25 more
core   +1 more source

Midkine (MDK) growth factor::a key player in cancer progression and a promising therapeutic target [PDF]

, 2019
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development ...
George S. Karagiannis, Filippou, Panagiota S.; id_orcid, Panagiota S. Filippou, Filippou, Panagiota S., Constantinidou, Anastasia, Karagiannis, George, Anastasia Constantinidou   +6 more
core   +1 more source

A Lymphoreporter Mouse Model Identifies Midkine as a Metastasis Driver

, 2017
Midkine systemically induces neo-lymphangiogenesis via mTOR signaling in patients with melanoma.

core   +1 more source

Midkine in Advanced Prostate Cancer - Biological Impact and Biomarker Potential [PDF]

, 2017
Prostate cancer (PC) is generally an androgen-driven disease, why androgen deprivation therapy (ADT) is the cornerstone for treatment of advanced and metastatic hormone-naïve PC (HNPC).
Nordin, Anna
core   +1 more source

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer-4

, 2011
Es. Expression of E1A was analyzed by RT-PCR. (B) Adenoviral hexon staining. HEK293 cells were infected with Ad5MK prepared from subcutaneous xenografts after injection of adenoviruses.
Tatsuo Ito (95905), Toshihiko Masui (95906), Shinji Uemoto (95909), Kazuyuki Nagai (95904), Ryuichiro Doi (95898), Tomohiko Mori (95900), Masayuki Koizumi (95902), Daisuke Ito (95901), Kazuhiro Kami (95899), Eiji Toyoda (95897), Atsushi Kida (95903), Masatoshi Tagawa (95908), Michihiko Wada (95907)   +12 more
core   +1 more source

Einfluss der Heparin-bindenden Wachstumsfaktoren Pleiotrophin und Midkine auf mesenchymale Stammzellen

, 2006
Osteoporose ist eine Krankheit, die in unserer Gesellschaft mit zunehmender Inzidenz auftritt. Derzeit stehen aber nur ungenügend Therapieverfahren zur Verfügung.
Behr, Katharina
core   +1 more source