Results 71 to 80 of about 4,425 (166)

Serum Midkine Levels in Systemic Lupus Erythematosus

, 2018
BACKGROUND: Midkine (MK) induces inflammation and could inhibit inducible regulatory T cell differentiation. These reports suggest that MK may play a role in the pathogenesis of autoimmune disease including SLE, but data about MK in SLE patients was ...
Ginting, Andi Raga, Marpaung, Blondina, Sjah, OK Moehad   +2 more
core   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, Volume 13, Issue 28, 18 May 2026.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

A guide to selecting high-performing antibodies for human Midkine for use in Western blot and immunoprecipitation [version 4; peer review: 2 approved]

F1000Research
Midkine is a secreted protein that acts as a growth factor or cytokine involved in cell survival and inflammatory processes. It accumulates in amyloid plaques, which are hallmarks of Alzheimer’s Disease (AD). The reproducibility of Midkine research would
Peter S. McPherson, Carl Laflamme, Aled M. Edwards, Kathleen Southern, Riham Ayoubi   +4 more
doaj   +1 more source

Midkine can not be accepted as a new biomarker for unexplained female infertility

Türk Biyokimya Dergisi, 2023
This study aimed to investigate whether a growth factor and a cytokine midkine (MK) can be a new biomarker for the diagnosis and treatment of unexplained female infertility (UFI) cases.
Ergüven Mine, Kahraman Semra, Pirkevi Caroline, İrez Tülay   +3 more
doaj   +1 more source

Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation

Glia, Volume 74, Issue 5, May 2026.
– CSF2, IL3, and TNFɑ directly promote microglial proliferation. – Neuron‐secreted factors suppress microglial proliferation. – IL1 cytokines promote CSF2 release from astrocytes, which promotes microglial proliferation. ABSTRACT Microglia—the predominant immune cell of the central nervous system (CNS)—possess an astounding capacity for proliferation ...
Brady P. Hammond, Eugene Hahn, Kelly V. Lee, Bradley J. Kerr, Jason R. Plemel   +4 more
wiley   +1 more source

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer-1

, 2011
Pressing cells were detected by fluorescence microscopy. (Original magnification ×100).Copyright information:Taken from "Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer"http://www.jeccr ...
Tatsuo Ito (95905), Toshihiko Masui (95906), Shinji Uemoto (95909), Kazuyuki Nagai (95904), Ryuichiro Doi (95898), Tomohiko Mori (95900), Masayuki Koizumi (95902), Daisuke Ito (95901), Kazuhiro Kami (95899), Eiji Toyoda (95897), Atsushi Kida (95903), Masatoshi Tagawa (95908), Michihiko Wada (95907)   +12 more
core   +1 more source

Midkine exacerbates pressure overload-induced cardiac remodeling

, 2014
Midkine is a multifunctional growth factor, and its serum levels are increased with the functional severity of heart failure. This study aimed to examine the role of midkine in heart failure pathogenesis.
Narumi, Taro, Shishido, Tetsuro, Watanabe, Tetsu, Kadowaki, Shinpei, Miyamoto, Takuya, Woo, Chang-Hoon, Kitahara, Tatsuro, Takeishi, Yasuchika, Kubota, Isao, Takahashi, Hiroki, Arimoto, Takanori, Funayama, Akira, Netsu, Shunsuke, Honda, Yuki, Nishiyama, Satoshi   +14 more
core   +1 more source

A guide to selecting high-performing antibodies for human Midkine for use in Western blot and immunoprecipitation [version 3; peer review: 2 approved]

F1000Research
Midkine is a secreted protein that acts as a growth factor or cytokine involved in cell survival and inflammatory processes. It accumulates in amyloid plaques, which are hallmarks of Alzheimer’s Disease (AD). The reproducibility of Midkine research would
Peter S. McPherson, Carl Laflamme, Aled M. Edwards, Kathleen Southern, Riham Ayoubi   +4 more
doaj   +1 more source

Association between serum midkine levels and tumor size in Indonesian hepatocellular carcinoma patients: a cross-sectional study

Romanian Journal of Internal Medicine, 2022
Background: The incidence of liver cancer is increased worldwide with 75%–85% diagnosed as hepatocellular carcinoma (HCC). Current practice has low sensitivity limitations to diagnose the early stages of HCC, thus urging the need for a biomarker with ...
Darmadi Darmadi, Ruslie Riska Habriel, Pakpahan Cennikon   +2 more
doaj   +1 more source

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer-3

, 2011
Ells were infected with Ad5GFP or Ad5MK at various MOIs. After 1, 3, and 5 days, the number of viable cells was counted.Copyright information:Taken from "Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human ...
Tatsuo Ito (95905), Toshihiko Masui (95906), Shinji Uemoto (95909), Kazuyuki Nagai (95904), Ryuichiro Doi (95898), Tomohiko Mori (95900), Masayuki Koizumi (95902), Daisuke Ito (95901), Kazuhiro Kami (95899), Eiji Toyoda (95897), Atsushi Kida (95903), Masatoshi Tagawa (95908), Michihiko Wada (95907)   +12 more
core   +1 more source