Results 1 to 10 of about 6,605 (141)

454 A novel MDK targeted therapy for the treatment of endometrial cancer [PDF]

Journal of Clinical and Translational Science
Objectives/Goals: Endometrial cancer (ECa) incidence is rising rapidly in women under 40 years of age, and response rates and progression-free survival remain poor in advanced ECa. New targeted therapies are urgently needed.
Emily Aller, Alondra L. Rodriguez Sanchez, Megharani Mahajan, Xue Yang, Paulina Ramirez, Panneerdoss Subbarayalu, Manjeet K. Rao, Edward R. Kost, Hareesh B. Nair, Ratna K. Vadlamudi, Suryavathi Viswanadhapalli   +10 more
doaj   +2 more sources

Targeting MDK Abrogates IFN-γ-Elicited Metastasis inCancers of Various Origins

Frontiers in Oncology, 2022
IFN-γ is a pleiotropic cytokine with immunomodulatory and tumoricidal functions. It has been used as an anti-tumor agent in adjuvant therapies for various cancers.
Shibin Chen, Lina Li, Xichen Dong
exaly   +3 more sources

Midkine as a novel prognostic and therapeutic target in meningioma: insights from single-cell analysis and organoid-based drug validation [PDF]

Journal of Translational Medicine
Background Recurrent meningiomas lack effective treatments beyond surgery and radiotherapy, necessitating novel prognostic biomarkers and therapeutic targets.
Pei-Ran Li, Fei-Yang Chen, Lai-Rong Song, Jun-Ting Zhang, Zhen Wu, Wei Chen, Liang Wang   +6 more
doaj   +2 more sources

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury [PDF]

Advanced Science
Acute kidney injury (AKI) is associated with a high prevalence of cognitive impairment, the underlying mechanisms remain elusive. This study explores the role of midkine (MDK), upregulated in renal injury, in mediating cognitive dysfunction following ...
Li Lu, Bixiao Liu, Yu Yang, Tao Meng, Yuanyuan Chang, Yao Peng, Jia Guo, Zhuqing Wang, Hongqian Guo, Liuhua Zhou, Xiaozhi Zhao   +10 more
doaj   +2 more sources

Targeting MDK alleviates bone loss via dual regulation of osteogenic differentiation and inflammatory cytokine expression [PDF]

Genes and Diseases
Growth factors are bioactive molecules that play crucial roles in regulating growth, development, and disease processes, both locally and systemically.
Xieyidai Ruze, Yutong Hu, Xiongyi Wang, Houfu Lai, Ruizhi Zhang, Sheng Pan, Jiajun Zhang, Yike Wang, Simin Yun, Ying Xu, Junjie Li, Youjia Xu   +11 more
doaj   +2 more sources

Dissecting the molecular mechanisms of T cell infiltration in psoriatic lesions via cell-cell communication and regulatory network analysis [PDF]

Open Life Sciences
This study aims to elucidate the intercellular communication mechanisms underlying T cell infiltration in psoriatic skin. Single-cell RNA sequencing revealed increased proportions of endothelial cells and T cells, alongside a reduction in melanocytes in ...
Li Kexin, Ge Xinhong, Shang Yuanyuan, Jiao Yaning, Dong Lingdi, Yu Yingyao   +5 more
doaj   +2 more sources

Coordinated changes in midkine expression and midkine-associated multiomic profile in glioma microenvironment [PDF]

Scientific Reports
Midkine (MDK), a multifunctional growth factor, has been implicated in promoting tumor progression, yet its role in glioblastoma (GBM) remains insufficiently characterized. To investigate MDK’s function in glioma, we integrated four RNA-Seq datasets into
Mieszko Lachota, Katarzyna Zielniok, Agata Góźdź, Patrycja Szpak, Ilona Kalaszczyńska, Radosław Zagożdżon   +5 more
doaj   +2 more sources

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk [PDF]

Advanced Science
While the function of biglycan (BGN) is recognized in various cancers, its precise role and the mechanisms underlying cancer‐associated fibroblasts (CAFs) formation within the melanoma tumor microenvironment (TME) remain poorly understood.
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
doaj   +2 more sources

Multi-Omics Integration Reveals Incomplete Reactivation of Developmental Cell-Cycle Programs in Adult Human Infarcted Hearts. [PDF]

Chem Biol Drug Des
Cross‐context integration of single‐nucleus, spatial, bulk transcriptomic, and chromatin accessibility data from human fetal and adult infarcted hearts reveals that infarct‐zone cardiomyocytes re‐enter the cell cycle but show insufficient reactivation of late mitotic and cytokinesis execution programs, suggesting that incomplete cytokinesis ...
Lyu J, Kuramoto Y, Li J, Lee JK, Hidaka K, Sakata Y.   +5 more
europepmc   +2 more sources

LBX2-AS1 in acceleration of glycolysis and cancer angiogenesis via miR-491-5p/MDK signaling axis in colorectal cancer: an experimental study [PDF]

Annals of Medicine
Background Recent studies have identified various roles for long non-coding RNAs (lncRNAs) in cancer progression. However, an in-depth understanding of the regulatory mechanisms of lncRNAs in colorectal cancer (CRC) and their diagnostic significance is ...
Juan Wang, Chao Li, Guanghai Wu, Jing Xu
doaj   +2 more sources