Results 21 to 30 of about 8,365 (225)

Midkine (MDK) as a central regulator of the tumor microenvironment: From developmental cytokine to therapeutic target [PDF]

Cancer Letters
Hareesh B Nair, Ajay Nair, Ya-Guang Liu   +2 more
exaly   +2 more sources

Serum midkine levels for the diagnosis and assessment of response to interventional therapy in patients with hepatocellular carcinoma

Journal of Interventional Medicine, 2021
Objective: To explore the clinical significance of serum midkine (MDK) levels for the diagnosis of hepatocellular carcinoma (HCC) and evaluate the efficacy of interventional therapy.
Lin Zheng, Hailiang Li, Jinhua Huang, Jihoon Shin, Suxia Luo, Chenyang Guo, Yan Zhao, Fangkun Li   +7 more
doaj   +1 more source

Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma

Cancer Cell International, 2023
Background Research studies have demonstrated that Midkine (MDK) can influence the expression and activity of Renin-angiotensin system (RAS) components. Angiotensin II is involved in tumor growth and angiogenesis in different cancers.
Tai-Jan Chiu, Chang-Han Chen, Yi-Ju Chen, Yinshen Wee, Ching-Shuen Wang, Sheng‑Dean Luo   +5 more
doaj   +1 more source

Midkine promotes glioblastoma progression via PI3K-Akt signaling

Cancer Cell International, 2021
Background Our previous bioinformatics-based study found that midkine (MDK) was associated with poor prognosis of glioblastoma (GBM). However, the mechanism of MDK in GBM remains elusive.
Beiquan Hu, Chao Qin, Li Li, Lei Wei, Xianlun Mo, Huasheng Fan, Yuanhua Lei, Feng Wei, Donghua Zou   +8 more
doaj   +1 more source

Inhibition of Midkine Augments Osteoporotic Fracture Healing. [PDF]

PLoS ONE, 2016
The heparin-binding growth and differentiation factor midkine (Mdk) is proposed to negatively regulate osteoblast activity and bone formation in the adult skeleton.
Melanie Haffner-Luntzer, Julia Kemmler, Verena Heidler, Katja Prystaz, Thorsten Schinke, Michael Amling, Anna Kovtun, Anna E Rapp, Anita Ignatius, Astrid Liedert   +9 more
doaj   +1 more source

Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice. [PDF]

PLoS ONE, 2014
The growth and differentiation factor midkine (Mdk) plays an important role in bone development and remodeling. Mdk-deficient mice display a high bone mass phenotype when aged 12 and 18 months. Furthermore, Mdk has been identified as a negative regulator
Melanie Haffner-Luntzer, Aline Heilmann, Anna Elise Rapp, Simon Beie, Thorsten Schinke, Michael Amling, Anita Ignatius, Astrid Liedert   +7 more
doaj   +1 more source

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science
Elevated blood glucose levels may serve as an early indicator of underlying pancreatic cancer. Discriminating between pancreatic cancer‐associated new‐onset diabetes (PCAND) and new‐onset type 2 diabetes mellitus (T2DM) holds promise for enabling an ...
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
doaj   +2 more sources

MDK: A Target Enabling Package

, 2022
Midkine (MDK) is a secreted heparan-sulfate binding cytokine and plays many roles in the development of disease pathology, particularly in neurodegeneration.
Katerina Gospodinova, Haian Fu, TREAT-AD consortium, Qianjin Li, Paul Brennan, Ranjita Betarbet   +5 more
core   +1 more source

Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation

Journal of Neuroinflammation, 2020
Background Midkine (MK) is a multifunctional cytokine found upregulated in the brain in the presence of different disorders characterized by neuroinflammation, including neurodegenerative disorders and ischemia.
Seiya Takada, Harutoshi Sakakima, Takahiro Matsuyama, Shotaro Otsuka, Kazuki Nakanishi, Kosuke Norimatsu, Yuki Itashiki, Akira Tani, Kiyoshi Kikuchi   +8 more
doaj   +1 more source

Midkine’s Role in Cardiac Pathology

Journal of Cardiovascular Development and Disease, 2017
Midkine (MDK) is a heparin-binding growth factor that is normally expressed in mid-gestational development mediating mesenchymal and epithelial interactions. As organisms age, expression of MDK diminishes; however, in adults, MDK expression is associated
Kathleen C. Woulfe, Carmen C. Sucharov
doaj   +1 more source