Results 1 to 10 of about 2,393 (119)

Midkine (MDK) in cancer and drug resistance: from inflammation to therapy [PDF]

Discover Oncology
Midkine (MDK) is a heparin-binding growth factor implicated in the pathogenesis of various diseases, including cancer, chronic inflammation, and multidrug resistance (MDR).
Ayhan Bilir
exaly   +5 more sources

Midkine (MDK) in Hepatocellular Carcinoma: More than a Biomarker [PDF]

Cells
Midkine (MDK) is a multifunctional secreted protein that can act as a cytokine or growth factor regulating multiple signaling pathways and being implicated in fundamental cellular processes, such as survival, proliferation, and migration.
Andreas Stylianou, Vasiliki Gkretsi
exaly   +6 more sources

Midkine (MDK) as a central regulator of the tumor microenvironment: From developmental cytokine to therapeutic target [PDF]

Cancer Letters
Midkine (MDK) is an oncofetal, heparin-binding cytokine that is re-expressed across diverse cancers and correlates with aggressive disease and treatment resistance. This review synthesizes current evidence on MDK as a coordinator of tumor-intrinsic signaling and microenvironmental remodeling.
Hareesh B Nair, Ajay Nair, Ya-Guang Liu   +2 more
exaly   +5 more sources

Inhibition of the Growth Factor MDK/Midkine by a Novel Small Molecule Compound to Treat Non-Small Cell Lung Cancer [PDF]

PLoS ONE, 2013
Midkine (MDK) is a heparin-binding growth factor that is highly expressed in many malignant tumors, including lung cancers. MDK activates the PI3K pathway and induces anti-apoptotic activity, in turn enhancing the survival of tumors.
Huifang Hao, Munenori Takaoka, Junji Matsuoka   +2 more
exaly   +5 more sources

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression [PDF]

Advanced Science
Cholesterol metabolism influences prostate cancer (PCa) progression, especially by affecting the tumor microenvironment. The present study demonstrated that cancer cell‐intrinsic cholesterol promoted the S‐palmitoylation of specificity protein 1 (SP1 ...
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
doaj   +3 more sources

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury [PDF]

Advanced Science
Acute kidney injury (AKI) is associated with a high prevalence of cognitive impairment, the underlying mechanisms remain elusive. This study explores the role of midkine (MDK), upregulated in renal injury, in mediating cognitive dysfunction following ...
Li Lu, Bixiao Liu, Yu Yang, Tao Meng, Yuanyuan Chang, Yao Peng, Jia Guo, Zhuqing Wang, Hongqian Guo, Liuhua Zhou, Xiaozhi Zhao   +10 more
doaj   +3 more sources

Coordinated changes in midkine expression and midkine-associated multiomic profile in glioma microenvironment [PDF]

Scientific Reports
Midkine (MDK), a multifunctional growth factor, has been implicated in promoting tumor progression, yet its role in glioblastoma (GBM) remains insufficiently characterized. To investigate MDK’s function in glioma, we integrated four RNA-Seq datasets into
Agata Góźdź, Ilona Kalaszczynska, Radoslaw Zagozdzon   +2 more
exaly   +3 more sources

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk [PDF]

Advanced Science
While the function of biglycan (BGN) is recognized in various cancers, its precise role and the mechanisms underlying cancer‐associated fibroblasts (CAFs) formation within the melanoma tumor microenvironment (TME) remain poorly understood.
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
doaj   +3 more sources

Pharmacological Targeting of Midkine (MDK) Reveals Stiffness-Dependent Control of Hepatocellular Carcinoma Invasiveness [PDF]

Int J Mol Sci
Metastasis accounts for most cancer-related deaths and hepatocellular carcinoma (HCC) is no exception. Midkine (MDK) is a multifunctional secreted protein elevated in HCC with a vague role in HCC. In this study, we used bioinformatics to verify MDK expression in HCC tumors, and next, we inhibited the MDK protein in invasive Hep3B cells using an MDK ...
Christou C, Agathangelou K, Dietis N, Stylianou A, Gkretsi V.   +4 more
europepmc   +3 more sources

Midkine Overexpression Promotes Functional Recovery After Spinal Cord Injury by Enhancing Microglial Efferocytosis Via LRP-1. [PDF]

CNS Neurosci Ther
Midkine (MDK) promotes functional recovery after spinal cord injury by enhancing microglial efferocytosis, reducing neuroinflammation, and decreasing neuronal apoptosis. Overexpression of MDK activates the AKT/mTOR pathway, upregulates LRP‐1 and BDNF, and drives microglia toward an anti‐inflammatory phenotype.
Wang Y, Fang L, Zhai C, Cai J, Li X, Zong L, Geng Y, Zhu C, Sun C, Dong M, Qian Y, Liu Y, Huang Y, Wang Z, Wang T, Liu WT, Wu Q.   +16 more
europepmc   +2 more sources