Results 31 to 40 of about 2,564 (146)

Midkine Expression as a Candidate Biomarker to Predict the Recurrence of Stage IA Lung Adenocarcinoma [PDF]

JTO Clinical and Research Reports
Background: Early recurrence limits the long-term survival of postoperative patients with stage IA lung adenocarcinoma (LUAD). This study aims to risk-stratify postoperative stage IA LUAD by means of the expression of Midkine (MDK). Materials and Methods:
Xiao Yang, PhD, Shuo Sun, BSc, Xunjie Kuang, BSc, Xianfeng Lu, MM, He Xiao, MM, Yi Duan, BSc, Yanli Xiong, MM, Di Zhang, BSc, Yu Xu, PhD, Jianwu Zhu, PhD, Mengxia Li, PhD   +10 more
doaj   +2 more sources

Combined Antineoplastic Effects of Metformin, Boric Acid and Resveratrol in SKOV3 Ovarian Cancer Cells [PDF]

Biomedicines
Background: Ovarian cancer (OC) is characterized by aggressive progression, high metastatic potential, and frequent resistance to conventional chemotherapy, highlighting the need for novel combination-based therapeutic strategies.
Burcu Biltekin, Mete Hakan Karalok, Seyma Dumur, Naile Fevziye Mısırlıoglu, Hafize Uzun   +4 more
doaj   +2 more sources

Diagnostic accuracy of midkine for hepatocellular carcinoma: A meta‐analysis

Molecular Genetics & Genomic Medicine, 2020
Background There have been many reports on midkine as a promising marker in the diagnosis of hepatocellular carcinoma (HCC). However, the results are inconsistent and even conflicting.
Yu Zhang, Juan Tang, Xiao Zhou, Shao‐Liang Zhu, Le‐Qun Li   +4 more
doaj   +2 more sources

Exploring drug resistance via intercellular crosstalk using spatial transcriptomics in high-grade serous ovarian carcinoma [PDF]

npj Precision Oncology
Poly(ADP-ribose) polymerase inhibitors (PARPis) have improved the prognosis of patients with high-grade serous ovarian carcinoma (HGSOC). However, PARPis are not effective for all HGSOC patients.
Hironori Suzuki, Kosuke Yoshida, Akira Yokoi, Kazuhiro Suzuki, Yuta Hirano, Masami Kitagawa, Eri Asano-Inami, Masato Yoshihara, Yukari Nagao, Satoshi Tamauchi, Nobuhisa Yoshikawa, Hiroaki Kajiyama, Yusuke Yamamoto   +12 more
doaj   +2 more sources

Midkine Deficiency Attenuates Lipopolysaccharide-Induced Pulmonary Inflammation. [PDF]

Int J Mol Sci
Midkine (MDK) is a multifunctional heparin-binding growth factor, and has been shown to regulate cell growth, survival, and migration. It also plays important roles in several inflammatory diseases such as sepsis.
Tanino Y, Wang X, Nikaido T, Sato Y, Togawa R, Watanabe N, Tanino M, Kadomatsu K, Shibata Y.   +8 more
europepmc   +2 more sources

Prognostic value of midkine, syndecan-1, hyaluronan synthase-2, sestrin-1, laminin subunit alpha-4 and fibulin-3 for malignant pleural mesothelioma

Archives of Medical Science, 2021
Introduction The prognosis of malignant pleural mesothelioma (MPM) is poor, with a limited survival time. In this study, we aimed to examine expression levels of genes selected from relevant literature and to utilize in silico methods to determine genes ...
Hakan Akgun, Selma Metintas, Guntulu Ak, Secil Demirkol Canlı, Murat Isbilen, Ali O. Gure, Muzaffer Metintas   +6 more
doaj   +1 more source

Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex

Cell Death and Disease, 2022
Midkine (MDK), a secreted growth factor, regulates signal transduction and cancer progression by interacting with receptors, and it can be internalized into the cytoplasm by endocytosis. However, its intracellular function and signaling regulation remain
Tian Xia, Di Chen, Xiaolong Liu, Huan Qi, Wen Wang, Huan Chen, Ting Ling, Wuxiyar Otkur, Chen-Song Zhang, Jongchan Kim, Sheng-Cai Lin, Hai-long Piao   +11 more
doaj   +1 more source

Diagnostic value of Midkine and AFP in the detection of hepatocellular carcinoma: A systematic review and meta-analysis [PDF]

Caspian Journal of Internal Medicine
Background: Hepatocellular carcinoma (HCC) posed significant health problems and deaths. There are various challenges in the management of HCC, including the late detection or diagnosis.
Masrul Lubis, Darmadi Darmadi, Sem Samuel Surja, Cennikon Pakpahan   +3 more
doaj   +1 more source

The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation. [PDF]

PLoS ONE, 2014
Midkine (MDK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. The Drosophila genome harbours two genes encoding members of the MDK/PTN family of proteins, known as miple1 and miple2.
Fredrik Hugosson, Camilla Sjögren, Anna Birve, Ludmilla Hedlund, Therese Eriksson, Ruth H Palmer   +5 more
doaj   +1 more source

MDK: A Target Enabling Package

, 2022
Midkine (MDK) is a secreted heparan-sulfate binding cytokine and plays many roles in the development of disease pathology, particularly in neurodegeneration.
Katerina Gospodinova, Haian Fu, TREAT-AD consortium, Qianjin Li, Paul Brennan, Ranjita Betarbet   +5 more
core   +1 more source