Results 51 to 60 of about 2,564 (146)

Midkine (Mdk) serum levels during fracture healing in 3-month-old sham-operated and ovariectomized (OVX) mice in pg/ml.

, 2016
Midkine (Mdk) serum levels during fracture healing in 3-month-old sham-operated and ovariectomized (OVX) mice in pg/ml.
Katja Prystaz (3154410), Julia Kemmler (765385), Verena Heidler (3154404), Anita Ignatius (142960), Astrid Liedert (504726), Michael Amling (133377), Anna Kovtun (3154407), Anna E. Rapp (2158540), Thorsten Schinke (126724), Melanie Haffner-Luntzer (504724)   +9 more
core   +1 more source

Machine learning identified MDK score has prognostic value for idiopathic pulmonary fibrosis based on integrated bulk and single cell expression data

Frontiers in Genetics, 2023
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease that poses a significant challenge to medical professionals due to its increasing incidence and prevalence coupled with the limited understanding of its underlying molecular ...
Shichen Zhang, Lanlan Zhang, Lu Wang, Hongqiu Wang, Jiaxin Wu, Haoyang Cai, Chunheng Mo, Jian Yang   +7 more
doaj   +1 more source

Targeting MDK Abrogates IFN-γ-Elicited Metastasis inCancers of Various Origins

Frontiers in Oncology, 2022
IFN-γ is a pleiotropic cytokine with immunomodulatory and tumoricidal functions. It has been used as an anti-tumor agent in adjuvant therapies for various cancers.
Luyu Zheng, Qun Liu, Ruijun Li, Shibin Chen, Jingyu Tan, Lina Li, Xichen Dong, Changzhi Huang, Tao Wen, Jian Liu, Jian Liu   +10 more
doaj   +1 more source

Midkine Prevents Calcification of Aortic Valve Interstitial Cells via Intercellular Crosstalk

Frontiers in Cell and Developmental Biology, 2021
Calcified aortic valve disease (CAVD), the most common valvular heart disease, lacks pharmaceutical treatment options because its pathogenesis remains unclear.
Qian Zhou, Qian Zhou, Qian Zhou, Hong Cao, Xiaoyi Hang, Xiaoyi Hang, Xiaoyi Hang, Huamin Liang, Huamin Liang, Huamin Liang, Miaomiao Zhu, Miaomiao Zhu, Miaomiao Zhu, Yixian Fan, Yixian Fan, Yixian Fan, Jiawei Shi, Nianguo Dong, Ximiao He, Ximiao He, Ximiao He   +20 more
doaj   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

The multifaceted role of midkine in gastrointestinal cancer: From biomarker to treatment

Cancer Treatment and Research Communications
Gastrointestinal cancer represents a substantial global health challenge, contributing to over one-third of cancer-related mortality worldwide. The progression of these malignancies involves complex molecular and physiological mechanisms, with Midkine ...
Zahra Rasoulizadeh, Amir Mohammad Nezhad Salari, Arezoo Gowhari Shabgah, Ghasem Sargazi, Roghayyeh Vakili-Ghartavol, Najmeh Mohammadpour, Reza Beheshti Monfared, Jamshid Gholizadeh   +7 more
doaj   +1 more source

USP12 promotes breast cancer angiogenesis by maintaining midkine stability

Cell Death and Disease, 2021
Deubiquitinases (DUBs) have important biological functions, but their roles in breast cancer metastasis are not completely clear. In this study, through screening a series of DUBs related to breast cancer distant metastasis-free survival (DMFS) in the ...
Bin Sheng, Zichao Wei, Xiaowei Wu, Yi Li, Zhihua Liu   +4 more
doaj   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Elevated Midkine Serum Levels Are Associated with Long-Term Survival in Critically Ill Patients

, 2023
Midkine (Mdk) is a multifunctional protein involved in inflammatory processes. Hence, circulating Mdk is increased in sepsis and has been previously suggested as a potential biomarker in these patients.
Eray Yagmur, Jule K. Adams, Theresa H. Wirtz, Ralf Weiskirchen, Frank Tacke, Karim Hamesch, Jonathan F. Brozat, Christian Trautwein, Philipp Hohlstein, Alexander Koch, Maike R. Pollmanns, Samira Abu Jhaisha, Lukas Bündgens, Dennis Wawer   +13 more
core   +1 more source

Correction: Inhibition of the Growth Factor MDK/Midkine by a Novel Small Molecule Compound to Treat Non-Small Cell Lung Cancer

PLOS ONE
[This corrects the article DOI: 10.1371/journal.pone.0071093.].
Huifang Hao, Yutaka Maeda, Takuya Fukazawa, Tomoki Yamatsuji, Munenori Takaoka, Xiao-Hong Bao, Junji Matsuoka, Tatsuo Okui, Tsuyoshi Shimo, Nagio Takigawa, Yasuko Tomono, Motowo Nakajima, Iris M Fink-Baldauf, Sandra Nelson, William Seibel, Ruben Papoian, Jeffrey A Whitsett, Yoshio Naomoto   +17 more
openaire   +4 more sources