Results 61 to 70 of about 2,564 (146)

Mapping the midkine family of developmentally regulated signaling molecules

, 1993
Midkine (Mdk) and heparin-binding neurotrophic factor (Hbnf)/pleiotrophin (Ptn) comprise the Midkine family of developmentally regulated signaling molecules.
Scherer, SW, Peichel, CL, Tsui, L C, Beier, DR, Scherer, S W, Tsui, LC, Beier, D R, Peichel, Catherine L, Vogt, TF, Vogt, T F   +9 more
core   +1 more source

Comprehensive analysis and functional validation of key genes in bladder cancer progression

VIEW, Volume 7, Issue 3, June 2026.
Bladder cancer is highly diverse between patients, making it difficult to accurately predict who will have aggressive disease and poor outcomes. In this study, we integrated single‐cell RNA sequencing with clinical survival data to identify a simple three‐gene signature (FAM3B, C10orf99, and VMP1) that stratifies patients into high‐ and low‐risk groups.
Xiaoning Cheng, Hongxia Zhao, Qian Li, Boyang Liu, Maoping Cai, Xinyi Wang, Jiancong Lie, Yuanyuan Qu, Jianwei Li, Chunlong Yang   +9 more
wiley   +1 more source

Midkine promotes renal fibrosis by stabilizing C/EBPβ to facilitate endothelial-mesenchymal transition

Communications Biology
Numerous myofibroblasts are arisen from endothelial cells (ECs) through endothelial to mesenchymal transition (EndMT) triggered by TGF-β. However, the mechanism of ECs transforms to a different subtype, or whether there exists an intermediate state of ...
Cuidi Xu, Juntao Chen, Lifei Liang, Siyue Chen, Xinhao Niu, Ruirui Sang, Cheng Yang, Ruiming Rong   +7 more
doaj   +1 more source

Multi‐Omics Integration Reveals Incomplete Reactivation of Developmental Cell‐Cycle Programs in Adult Human Infarcted Hearts

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Cross‐context integration of single‐nucleus, spatial, bulk transcriptomic, and chromatin accessibility data from human fetal and adult infarcted hearts reveals that infarct‐zone cardiomyocytes re‐enter the cell cycle but show insufficient reactivation of late mitotic and cytokinesis execution programs, suggesting that incomplete cytokinesis ...
Jieran Lyu, Yuki Kuramoto, Jun Li, Jong‐Kook Lee, Kyoko Hidaka, Yasushi Sakata   +5 more
wiley   +1 more source

The estrogen response in fibroblasts promotes ovarian metastases of gastric cancer

Nature Communications
Younger premenopausal women are more prone to developing ovarian metastases (OM) of gastric cancer (GC) than metastases of other organs; however, the molecular mechanisms remain unclear. Here we perform single-cell RNA sequencing on 45 tumor samples from
Simeng Hu, Can Hu, Jingli Xu, Pengfei Yu, Li Yuan, Ziyu Li, Haohong Liang, Yanqiang Zhang, Jiahui Chen, Qing Wei, Shengjie Zhang, Litao Yang, Dan Su, Yian Du, Zhiyuan Xu, Fan Bai, Xiangdong Cheng   +16 more
doaj   +1 more source

Mean serum MDK, OPN and DKK1 concentrations in HCC and control groups.

, 2016
A–C) MDK, OPN and DKK1 levels respectively for HCC and control groups. Mean values and 95% confidence intervals are shown. Abbreviations: MDK, midkine; OPN, osteopontin; DKK1, dickopff-1; HCC, hepatocellular carcinoma; CLD, chronic liver disease; HC ...
Simone I. Strasser (799325), Roslyn Vongsuvanh (2806705), Tristan Iseli (2806702), Geoffrey W. McCaughan (410269), Jacob George (205614), David van der Poorten (241663)   +5 more
core   +1 more source

Midkine level may be used as a noninvasive biomarker in Crohn's disease [PDF]

, 2020
Background/aim: Crohn's disease (CD) is a kind of inflammatory bowel disease. Midkine (MDK) is an endogenous inflammatory marker. We aimed to investigate the relationship between MDK levels and inflammation and hence determine whether MDK can be used as ...
Can, Murat, Cakal, Basak, Duzenli, Tolga, Tanoglu, Alpaslan, Dogan, Zeynal, Karaahmet, Fatih, Kekilli, Murat, BEYAZIT, YAVUZ, Sayilir, Abdurrahim   +8 more
core   +1 more source

Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation

Journal of Neuroinflammation, 2020
Background Midkine (MK) is a multifunctional cytokine found upregulated in the brain in the presence of different disorders characterized by neuroinflammation, including neurodegenerative disorders and ischemia.
Seiya Takada, Harutoshi Sakakima, Takahiro Matsuyama, Shotaro Otsuka, Kazuki Nakanishi, Kosuke Norimatsu, Yuki Itashiki, Akira Tani, Kiyoshi Kikuchi   +8 more
doaj   +1 more source

DSG2+ Cancer Stem Cells Co‐Located With FAP+ Myofibroblasts in the Tumor Boundary That Determines the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Cancer stem cells (CSCs) in non‐small cell lung cancer display pronounced plasticity and spatial heterogeneity. By integrating single‐cell and spatial transcriptomics, this study defines a DSG2‐associated CSC program and reveals a tumor‐margin niche formed with FAP+ myofibroblasts.
Guangyu Fan, Le Tang, Tongji Xie, Mengwei Yang, Lin Li, Sheng Yang, Puyuan Xing, Xiaohong Han, Yuankai Shi   +8 more
wiley   +1 more source

Significance of Midkine Signaling in Women's Cancers: Novel Biomarker and Therapeutic Target. [PDF]

Int J Mol Sci
Midkine (MDK) is a multifunctional protein that is secreted into the extracellular space. It functions as a cytokine or growth factor, modulating a variety of signaling pathways implicated in angiogenesis, antitumor immunity, metastasis, and therapy ...
Aller EJ, Nair HB, Vadlamudi RK, Viswanadhapalli S.   +3 more
europepmc   +2 more sources