Results 81 to 90 of about 2,564 (146)

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

Image_1_Targeting MDK Abrogates IFN-γ-Elicited Metastasis inCancers of Various Origins.tif

, 2022
IFN-γ is a pleiotropic cytokine with immunomodulatory and tumoricidal functions. It has been used as an anti-tumor agent in adjuvant therapies for various cancers.
Tao Wen (304736), Xichen Dong (12815672), Jian Liu (33711), Shibin Chen (6881042), Luyu Zheng (12815666), Qun Liu (67203), Lina Li (292076), Jingyu Tan (12815669), Ruijun Li (3247911), Changzhi Huang (577790)   +9 more
core   +1 more source

Evaluating miRNA Sequencing and Integrative Proteomics for Identifying Plasma miRNAs as Potential Pharmacodynamic Biomarkers of IFNβ‐1a Biologics

Clinical and Translational Science, Volume 18, Issue 12, December 2025.
ABSTRACT We used miRNA sequencing to identify candidate plasma pharmacodynamic (PD) biomarkers of interferon beta‐1a (IFNβ‐1a) biologics and explored miRNA‐mRNA targeted protein relationships and networks to support identified miRNA candidates. Plasma samples from 36 healthy subjects from a placebo‐controlled randomized single‐dose clinical study with ...
Mai Mehanna, Lakshmi Manasa Chekka, Barry A. Rosenzweig, Deepti P. Samarth, Esraa G. Mohamed, Isaac Raplee, Catherine Sullenberger, Erica Decker, Sarah J. Schrieber, Yow‐Ming Wang, Jeffry Florian, Paula L. Hyland   +11 more
wiley   +1 more source

Antagonizing midkine accelerates fracture healing in mice by enhanced bone formation in the fracture callus

, 2016
Background and Purpose Previous findings suggest that the growth and differentiation factor midkine (Mdk) is a negative regulator of osteoblast activity and bone formation, thereby raising the possibility that a specific Mdk antagonist might improve ...
Thorsten Schinke, Rössler, Robin, Amling, Michael, Aline Heilmann, Rapp, Anna Elise, Anita Ignatius, Schinke, Thorsten, Anna Elise Rapp, Astrid Liedert, Haffner-Luntzer, Melanie, Liedert, Astrid, Robin Roessler, Heilmann, Aline, Melanie Haffner‐Luntzer, Michael Amling, Ignatius, Anita   +15 more
core   +1 more source

Evaluation of midkine and anterior gradient 2 in a multimarker panel for the detection of ovarian cancer

Journal of Experimental & Clinical Cancer Research, 2010
The aims of this study were: to characterise and compare plasma concentrations of midkine (MDK) in normal healthy women with concentrations observed in women with ovarian cancer; and to establish and compare the performance of MDK with that of anterior ...
Edgell Tracey A, Rice Gregory E, Autelitano Dominic J   +2 more
doaj   +1 more source

Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action

, 2011
Acknowledgements This work was supported by grants from Spanish Ministry of Science and Innovation (MICINN) (PS09/01401; HF2005/0021, FR2009-0052 and IT2009-0053 to GV; SAF2006/00918 to MG), Santander-Complutense (PR34/07-15856 to GV), Comunidad de ...
M Lorente, Y Campos-Martín, Carracedo, Arkaitz, Campos Martín, Yolanda, García-Taboada, Elena, Salazar, María, S Torres, Hernández Tiedra, Sonia, Barcia, Juan, Guzmán, Manuel, Torres, Sofía, Mollejo, Manuela, Salazar Roa, María, M Salazar, Lakatosh, Sergey, S Hernández-Tiedra, Lorente Pérez, María Del Mar, Rodríguez-Fornés, Fátima, García Taboada, Elena, Campos, Yolanda, M Mollejo, Velasco Díez, Guillermo, Hernández-Tiedra, Sonia, B Meléndez, Meléndez, Bárbara, Guzmán Pastor, Manuel, Lorente, Mar, E García-Taboada, M Guzmán, Rodríguez Fornés, Fátima, G Velasco, J Barcia, Barcia Albacar, Juan Antonio, Velasco, Guillermo, S A Lakatosh, A Carracedo, F Rodríguez-Fornés   +36 more
core   +1 more source

The diagnostic value of midkine as a novel serum biomarker in alpha-fetoprotein-negative hepatocellular carcinoma

The International Journal of Biological Markers
Objective The objective of this study is to investigate the correlation between the expression levels of midkine (MDK) in the serum of patients with hepatocellular carcinoma (HCC) and various clinical features, and to evaluate the diagnostic efficacy of ...
Liuyi Lu, Chunling Zhu, Liling Yi, Siting Li, Mengli Fan, Jiayao Lin, Qiliu Peng   +6 more
doaj   +1 more source

Plasma midkine concentrations in healthy children, children with increased and decreased adiposity, and children with short stature.

PLoS ONE, 2019
BackgroundMidkine (MDK), one of the heparin-binding growth factors, is highly expressed in multiple organs during embryogenesis. Plasma concentrations have been reported to be elevated in patients with a variety of malignancies, in adults with obesity ...
Youn Hee Jee, Kun Song Lee, Shanna Yue, Ellen W Leschek, Matthew G Boden, Aysha Jadra, Anne Klibanski, Priya Vaidyanathan, Madhusmita Misra, Young Pyo Chang, Jack A Yanovski, Jeffrey Baron   +11 more
doaj   +1 more source

Comparison of the diagnostic performances of serum MDK, OPN and AFP.

, 2016
A) All HCC patients versus non-HCC patients (cirrhotics and chronic liver disease). B) Early HCC patients (BCLC 0-A) versus non-HCC patients (cirrhotic and chronic liver disease). C) HCV-HCC patients versus HCV-cirrhotics.
Simone I. Strasser (799325), Roslyn Vongsuvanh (2806705), Tristan Iseli (2806702), Geoffrey W. McCaughan (410269), Jacob George (205614), David van der Poorten (241663)   +5 more
core   +1 more source

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science
Elevated blood glucose levels may serve as an early indicator of underlying pancreatic cancer. Discriminating between pancreatic cancer‐associated new‐onset diabetes (PCAND) and new‐onset type 2 diabetes mellitus (T2DM) holds promise for enabling an ...
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
doaj   +1 more source