Results 91 to 100 of about 2,564 (146)

High-level Soluble Expression, Purification and Characterization of Active Human Midkine from Escherichia coli

, 2009
Midkine (MDK) belongs to a class of heparin-binding growth factors and is highly expressed in a number of cancers. MDK is a cysteine-rich 13 kDa protein containing five disulfide bonds.
Hofmann, Gabriele, Sim, Bang Janet, Yan, Wei, Goette, Marjo, Zaror, Isabel   +4 more
core   +1 more source

Targeting the MDK/c‐Myc complex to overcome temozolomide resistance in glioma

Clinical and Translational Medicine
Background Temozolomide (TMZ), which is an alkylating agent, is the standard chemotherapeutic drug used for glioma treatment. However, the development of resistance to TMZ limits its efficacy.
Xiaonan Xi, Xiaojing Ding, Qianqian Wang, Ning Liu, Bangmao Wang, Genbei Wang, Weilong Zhong, Yaxin Lu   +7 more
doaj   +1 more source

Impact of alcohol abuse on protein expression of midkine and excitatory amino acid transporter 1 in the human prefrontal cortex

, 2008
Background: Alcoholism is associated with shrinkage of brain tissue and reduction in the number of neurons and dendritic arbors particularly in the prefrontal cortex. These changes correlate with the cognitive defects common in alcoholics. A recent study
Peter A. Wilce, Wilce, Peter A., Flatscher-Bader, Traute, Traute Flatscher‐Bader   +3 more
core   +1 more source

The Angiogenic Growth Factor and Biomarker Midkine Is a Tumor-Shared Antigen

, 2010
International audienceThe angiogenic factor Midkine (MDK) is overexpressed in various human malignant tumors, although its expression is low or undetectable in normal adult tissues.
Bernardeau, Karine, Kerzerho, Jerome, Dosset, Magalie, Tartour, Eric, Szely, Natacha, Castelli, Florence, Lang, Francois, Adotevi, Olivier, Maillere, Bernard   +8 more
core   +1 more source

Midkine (MDK) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Untersuchungen zum Einfluss von Matrix und mechanischer Belastung auf die Expression von c-FOS, PTN und MDK in mesenchymalen Stammzellen

, 2014
In dieser Arbeit wurde der Einfluss zyklischer, uniaxialer Dehnung auf die Expression der im Knochenstoffwechsel wichtigen Proteine c-FBJ murine osteosarcoma viral oncogene homolog (c-FOS), Pleiotrophin (PTN) und Midkine (MDK) in Abhängigkeit von ...
Nitschko, Corinna
core   +1 more source

Changes of Serum Midkine as a Dynamic Prognostic Factor in Detection for Thyroid Cancer and Comparison with Fine-Needle Aspiration

Background: Midkine plays a significant role in the pathophysiology of malignant and other diseases since it is involved in a number of physiological processes, including development, reproduction, and repair.
Al-Rubaiawi, Hadel Kareem, Alhelfy, Sajid H., Mohamed, Raid J., Yones, Marwah S.   +3 more
core   +1 more source

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma

Advanced Science
Lung squamous cell carcinoma (LUSC) remains a lethal malignancy with limited therapeutic advancements, underscoring the need to identify novel oncogenic drivers.
Yong‐Qiang Ning, Jie Wang, Yihui Zhang, Hongrui Li, Zenan Jiang, Xinyu Su, Xiao Yang, Xiaoxuan Wu, Bing Wei, Jianmin Ying, Jian Yan, Wenbin Li   +11 more
doaj   +1 more source

Midkine-välitteinen signalointi munasarjojen munarakkuloissa : Näkökulmia granuloosasolumallista ja ihmisen munasarjakudoksesta

The ovaries are a central organ to female reproductive physiology, producing mature oocytes and hormones essential for fertility and pregnancy. Despite extensive research, the mechanisms regulating the survival, activation, and development of ovarian ...
Saarinen, Anemone Saida Fei
core  

Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation

博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Background: Midkine (MK) is a multifunctional cytokine found upregulated in the brain in the presence of different disorders characterized by neuroinflammation, including neurodegenerative disorders and ischemia.
タカダ, セイヤ, 髙田, 聖也, Takada, Seiya   +2 more
core