Results 11 to 20 of about 2,564 (146)
The role of midkine in health and disease [PDF]
Frontiers in Immunology, 2023 Midkine (MDK) is a neurotrophic growth factor highly expressed during embryogenesis with important functions related to growth, proliferation, survival, migration, angiogenesis, reproduction, and repair.
Veit Rothhammer +2 more
exaly +4 more sources
Targeting MDK alleviates bone loss via dual regulation of osteogenic differentiation and inflammatory cytokine expression [PDF]
Genes and DiseasesGrowth factors are bioactive molecules that play crucial roles in regulating growth, development, and disease processes, both locally and systemically.
Xieyidai Ruze +11 more
doaj +3 more sources
Inhibition of Midkine Augments Osteoporotic Fracture Healing. [PDF]
PLoS ONE, 2016 The heparin-binding growth and differentiation factor midkine (Mdk) is proposed to negatively regulate osteoblast activity and bone formation in the adult skeleton.
Melanie Haffner-Luntzer +9 more
doaj +2 more sources
Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target [PDF]
Oncogene, 2019 Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development.
Panagiota S. Filippou +2 more
openaire +4 more sources
Midkine and Pleiotrophin Concentrations in Amniotic Fluid in Healthy and Complicated Pregnancies. [PDF]
PLoS ONE, 2016 Midkine (MDK) and pleiotrophin (PTN) are heparin-binding growth factors that, in rodents, are highly expressed in early life and decrease to undetectable levels by adulthood.
Youn Hee Jee +7 more
doaj +2 more sources
Molecular Biology of the Cell, 2015 Midkine (MDK) expression is associated with the proliferation of many cancers, including glioma. However, the upstream signaling that leads to MDK accumulation remains elusive. This study investigates the molecular mechanism that induces MDK overexpression in human glioma.
Zhibo Xia, Lixuan Yang, Shiyuan Chen
exaly +3 more sources
Genomics, 1993 Midkine (MDK) is a retinoic acid-responsive gene concerned with prenatal development and neurite growth. We mapped the gene to band p11.2 of chromosome 11 through fluorescence in situ hybridization analysis and using a 4.5-kb fragment of its human genomic DNA.
Tadashi Kaname +2 more
exaly +3 more sources
Midkine: A Cancer Biomarker Candidate and Innovative Therapeutic Approaches [PDF]
European Journal of Breast HealthMidkine (MDK) is a protein that contributes to both physiological and pathological processes. Several studies provide insight into the different roles of MDK in development, tissue repair, neural plasticity, and health and disease processes.
Berna Yıldırım +2 more
doaj +2 more sources
Stress-Induced Activation of Prolactin-NR4A1-Midkine Axis Exacerbates Skin Inflammation. [PDF]
Adv Sci (Weinh)Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Li Z +18 more
europepmc +2 more sources
Unveiling critical signaling pathways in the murine salivary gland and the role of midkine [PDF]
iScienceSummary: Salivary gland (SG) development is a complex process involving coordinated signaling between epithelial and stromal cell populations. While some growth drivers and branching mechanisms are known, many intercellular communication pathways that ...
Theresa Wrynn +3 more
doaj +2 more sources