Results 21 to 30 of about 2,564 (146)

Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma. [PDF]

PLoS ONE, 2016
UnlabelledRobust biomarkers for population-level hepatocellular carcinoma (HCC) surveillance are lacking. We compared serum midkine (MDK), dickkopf-1 (DKK1), osteopontin (OPN) and AFP for HCC diagnosis in 86 HCC patients matched to 86 cirrhotics, 86 with
Roslyn Vongsuvanh, David van der Poorten, Tristan Iseli, Simone I Strasser, Geoffrey W McCaughan, Jacob George   +5 more
doaj   +3 more sources

Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice. [PDF]

PLoS ONE, 2014
The growth and differentiation factor midkine (Mdk) plays an important role in bone development and remodeling. Mdk-deficient mice display a high bone mass phenotype when aged 12 and 18 months. Furthermore, Mdk has been identified as a negative regulator
Melanie Haffner-Luntzer, Aline Heilmann, Anna Elise Rapp, Simon Beie, Thorsten Schinke, Michael Amling, Anita Ignatius, Astrid Liedert   +7 more
doaj   +2 more sources

Pleiotrophin/Midkine Pathway Is Dysregulated in a TDP-43^A315T Mouse Model of Amyotrophic Lateral Sclerosis (ALS). [PDF]

Neuropathology
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Martínez-Alesón P, Benito-Casado C, Fernández-Martos CM, Polanco Mora MJ.   +3 more
europepmc   +2 more sources

Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma

Cancer Cell International, 2023
Background Research studies have demonstrated that Midkine (MDK) can influence the expression and activity of Renin-angiotensin system (RAS) components. Angiotensin II is involved in tumor growth and angiogenesis in different cancers.
Tai-Jan Chiu, Chang-Han Chen, Yi-Ju Chen, Yinshen Wee, Ching-Shuen Wang, Sheng‑Dean Luo   +5 more
doaj   +2 more sources

Serum Midkine and Osteopontin Levels as Diagnostic Biomarkers of Hepatocellular Carcinoma

Electronic Physician, 2017
Introduction: Hepatocellular Carcinoma (HCC) is a primary tumor of the liver; it is one of the most common cancers worldwide. Osteopontin (OPN) is a phosphorylated glycoprotein which is implicated in enhancing invasive and metastatic progression of ...
Hossam Hodeib, Ola ELshora, Amal Selim, Nesreen Mohammed Sabry, Heba Mohamed EL-ashry   +4 more
doaj   +2 more sources

The Value of Serum Midkine Level in Diagnosis of Hepatocellular Carcinoma [PDF]

International Journal of Hepatology, 2015
Background and Aim. Identification of sensitive biomarkers to improve early diagnosis of HCC is needed. We aimed to evaluate serum midkine (MDK) as a biomarker for HCC diagnosis. Patients and Methods.
Karim Y. A. Shaheen, Abeer I. Abdel-Mageed, Eslam Safwat, Ashraf M. AlBreedy   +3 more
doaj   +2 more sources

Assessing Aβ-independent effects of Module 42 on immune function in vitro. [PDF]

Alzheimers Dement
Abstract INTRODUCTION A deep multi‐omic analysis of post mortem human brains has identified a new co‐expression protein network – Module 42 (M42), strongly corelated with Alzheimer's disease (AD) pathology. M42 comprises 32 transmembrane and extracellular matrix (ECM)‐associated proteins, including the amyloid precursor protein (APP) and apolipoprotein
Ajith I, Bakshi S, Mead E, Gileadi O, Katis VL, Brennan PE, Emory‐Sage‐SGC‐Jax TREAT‐AD Center, Gospodinova KO.   +7 more
europepmc   +2 more sources

454 A novel MDK targeted therapy for the treatment of endometrial cancer [PDF]

Journal of Clinical and Translational Science
Objectives/Goals: Endometrial cancer (ECa) incidence is rising rapidly in women under 40 years of age, and response rates and progression-free survival remain poor in advanced ECa. New targeted therapies are urgently needed.
Emily Aller, Alondra L. Rodriguez Sanchez, Megharani Mahajan, Xue Yang, Paulina Ramirez, Panneerdoss Subbarayalu, Manjeet K. Rao, Edward R. Kost, Hareesh B. Nair, Ratna K. Vadlamudi, Suryavathi Viswanadhapalli   +10 more
doaj   +2 more sources

LBX2-AS1 in acceleration of glycolysis and cancer angiogenesis via miR-491-5p/MDK signaling axis in colorectal cancer: an experimental study [PDF]

Annals of Medicine
Background Recent studies have identified various roles for long non-coding RNAs (lncRNAs) in cancer progression. However, an in-depth understanding of the regulatory mechanisms of lncRNAs in colorectal cancer (CRC) and their diagnostic significance is ...
Juan Wang, Chao Li, Guanghai Wu, Jing Xu
doaj   +2 more sources

Midkine Promotes Tumor Growth and Attenuates the Effect of Cisplatin in Small Cell Lung Cancer [PDF]

Cancer Medicine
Purpose Small cell lung cancer (SCLC) is a highly aggressive disease associated with poor patient survival rates. The addition of an anti‐programmed death ligand 1 antibody to platinum combination chemotherapy can improve its prognosis.
Shotaro Ito, Jun Sakakibara‐Konishi, Mineyoshi Sato, Tetsuaki Shoji, Megumi Furuta, Hirofumi Takahashi, Kosuke Tsuji, Daisuke Morinaga, Masahiro Kashima, Hidenori Kitai, Junko Kikuchi, Eiki Kikuchi, Kanako C. Hatanaka, Yutaka Hatanaka, Kyoko Hida, Takuro Noguchi, Satoshi Konno   +16 more
doaj   +2 more sources