Results 11 to 20 of about 8,365 (225)

Midkine (MDK) in cancer and drug resistance: from inflammation to therapy [PDF]

Discover Oncology
Midkine (MDK) is a heparin-binding growth factor implicated in the pathogenesis of various diseases, including cancer, chronic inflammation, and multidrug resistance (MDR).
Ayhan Bilir
exaly   +3 more sources

MDK promotes M2 macrophage polarization to remodel the tumour microenvironment in clear cell renal cell carcinoma

Scientific Reports
The efficacy of immunotherapy for clear cell renal cell carcinoma (ccRCC), especially advanced ccRCC, is limited, presenting a clinical challenge. This limitation is closely tied to the immune regulation network.
Tiange Wu, Nieke Zhang, Xuefei Ding
exaly   +3 more sources

Inhibition of the growth factor MDK/midkine by a novel small molecule compound to treat non-small cell lung cancer. [PDF]

PLoS ONE, 2013
Midkine (MDK) is a heparin-binding growth factor that is highly expressed in many malignant tumors, including lung cancers. MDK activates the PI3K pathway and induces anti-apoptotic activity, in turn enhancing the survival of tumors.
Huifang Hao, Yutaka Maeda, Takuya Fukazawa, Tomoki Yamatsuji, Munenori Takaoka, Xiao-Hong Bao, Junji Matsuoka, Tatsuo Okui, Tsuyoshi Shimo, Nagio Takigawa, Yasuko Tomono, Motowo Nakajima, Iris M Fink-Baldauf, Sandra Nelson, William Seibel, Ruben Papoian, Jeffrey A Whitsett, Yoshio Naomoto   +17 more
doaj   +2 more sources

MDK-Prüfung: Verschwendete Versichertengelder

kma - Klinik Management aktuell, 2017
Das Prüfverfahren des MDK schießt am Ziel vorbei und begünstigt unberechtigte Rechnungskürzungen ebenso wie betrügerische Kodierungspraktiken, meint unser Gastautor Nikolai von Schroeders. Außerdem stehe der Aufwand der Prüfungen in keinem Verhältnis zum Ertrag.
Nikolai von Schroeders
openaire   +2 more sources

Combined Usage of MDK Inhibitor Augments Interferon-γ Anti-Tumor Activity in the SKOV3 Human Ovarian Cancer Cell Line

Biomedicines, 2022
Ovarian cancer (OC) is a particularly lethal disease due to intratumoral heterogeneity, resistance to traditional chemotherapy, and poor response to targeted therapy and immunotherapy.
Qun Liu, Jingyu Tan, Zhenguo Zhao, Ruijun Li, Luyu Zheng, Xiangyu Chen, Lina Li, Xichen Dong, Tao Wen, Jian Liu   +9 more
doaj   +2 more sources

Midkine (MDK) in Hepatocellular Carcinoma: More than a Biomarker

Cells
Midkine (MDK) is a multifunctional secreted protein that can act as a cytokine or growth factor regulating multiple signaling pathways and being implicated in fundamental cellular processes, such as survival, proliferation, and migration.
Christiana Christou, Andreas Stylianou, Vasiliki Gkretsi   +2 more
doaj   +2 more sources

Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma

Journal of Experimental & Clinical Cancer Research, 2018
Background Exosomes are small vesicles containing a wide range of functional proteins, mRNA and miRNA. Exosomal miRNAs from cancer cells play crucial roles in mediating cell-cell communication and tumor-microenvironment cross talk, specifically in ...
Juan Lu, Qi-Hui Liu, Fan Wang, Jia-Jie Tan, Yue-Qin Deng, Xiao-Hong Peng, Xiong Liu, Bao Zhang, Xia Xu, Xiang-Ping Li   +9 more
doaj   +2 more sources

Targeting the MDK/c‐Myc complex to overcome temozolomide resistance in glioma

Clinical and Translational Medicine
Background Temozolomide (TMZ), which is an alkylating agent, is the standard chemotherapeutic drug used for glioma treatment. However, the development of resistance to TMZ limits its efficacy.
Xiaonan Xi, Qianqian Wang, Bangmao Wang   +2 more
exaly   +2 more sources

Single-cell and spatial transcriptomics integration reveals FAM49B promotes tumor-associated macrophages polarization in colorectal cancer via the MK pathway [PDF]

Frontiers in Immunology
ObjectivesFAM49B has been shown to promote proliferation and metastasis of colorectal cancer (CRC) by stabilizing MYC through phosphorylation of NEK9; however, its role in shaping the immune suppressive tumor microenvironment (TME), particularly in ...
Tianyu Liu, Quchen Ding, Jin Gou, Chen Lu, Xingming Lu, Jiatong Chen, Yiming E., Lianhong Li, Chongguo Zhang, Xiaojuan Zhu, Chunzhao Yu, Chunzhao Yu, Xiagang Luo   +12 more
doaj   +2 more sources

Integrative single-cell and spatial transcriptomics analysis reveals MDK-NCL pathway’s role in shaping the immunosuppressive environment of lung adenocarcinoma [PDF]

Frontiers in Immunology
ObjectivesThe tumor microenvironment (TME) plays a critical role in the progression of lung adenocarcinoma (LUAD). This study aims to investigate the cellular composition of the TME in LUAD and assess the role of the MDK-NCL signaling pathway.MethodsWe ...
Yu Fu, Song Li, Yikang Zhao, Xiran Zhang, Xiaolu Mao, Ran Xu   +5 more
doaj   +2 more sources