Results 51 to 60 of about 7,018 (211)

Involvement of midkine in neuroblastoma tumourigenesis [PDF]

British Journal of Pharmacology, 2014
Midkine is highly expressed in various cancers, including neuroblastoma, one of the most malignant paediatric solid tumours known. Also, it has been shown to be useful as a tumour marker, a prognosis factor and a target of molecular therapy. Several molecular tools (e.g.
S, Kishida, K, Kadomatsu
openaire   +2 more sources

Midkine can not be accepted as a new biomarker for unexplained female infertility

Türk Biyokimya Dergisi, 2023
This study aimed to investigate whether a growth factor and a cytokine midkine (MK) can be a new biomarker for the diagnosis and treatment of unexplained female infertility (UFI) cases.
Ergüven Mine, Kahraman Semra, Pirkevi Caroline, İrez Tülay   +3 more
doaj   +1 more source

Physiology of Midkine and Its Potential Pathophysiological Role in COVID-19

Frontiers in Physiology, 2020
SARS-CoV2 infection not only causes abnormal severe pneumonia but also induces other relevant pathophysiological effects on several tissues and organs.
Giulia Sanino, Martino Bosco, Giuseppe Terrazzano, Giuseppe Terrazzano   +3 more
doaj   +1 more source

Combined proteome and transcriptome analyses for the discovery of urinary biomarkers for urothelial carcinoma [PDF]

, 2013
Background: Proteomic discovery of cancer biomarkers in body fluids is challenging because of their low abundance in a complex background. Altered gene expression in tumours may not reflect protein levels in body fluids.
A Martin, BM Bolstad, C Parr, C Parr, C Wang, C Yu, D G Ward, D Kaufman, D Tilki, E Cauberg, E Orenes-Piñero, Gordon K Smyth, H Kataoka, H Kawanishi, H Onda, I Waldhauer, J Salo, J Wiśniewski, K Chang, K K Cheng, K Nakamura, L Dyrskjøt, L Mengual, M Babjuk, M Grønborg, M Lindén, M Makridakis, M Muramaki, M P Zeegers, M Sánchez-Carbayo, M Volmer, M Yang, MP Zeegers, N Anderson, N D James, N J Shimwell, N James, N Nagaraj, N Yang, O Nagakawa, P J Johnson, R Bryan, R T Bryan, RA Irizarry, S Ikematsu, S Irmak, S Kageyama, S Ray, S Shariat, T O’Brien, W Wei, Y Chang, Y Chen, Y Lotan, Y Senga   +54 more
core   +3 more sources

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Sitagliptin Modulates Oxidative, Nitrative and Halogenative Stress and Inflammatory Response in Rat Model of Hepatic Ischemia-Reperfusion

Antioxidants, 2021
A possibility of repurposing sitagliptin, a well-established antidiabetic drug, for alleviating injury caused by ischemia-reperfusion (IR) is being researched.
Małgorzata Trocha, Mariusz G. Fleszar, Paulina Fortuna, Łukasz Lewandowski, Kinga Gostomska-Pampuch, Tomasz Sozański, Anna Merwid-Ląd, Małgorzata Krzystek-Korpacka   +7 more
doaj   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

Dienogest mediates midkine suppression in endometriosis [PDF]

Human Reproduction, 2016
What are the effects of dienogest (DNG) on midkine (MK) production in women with endometriosis?DNG-mediated down-regulation of MK in vivo and in vitro.DNG is an oral progestin that alleviates painful symptoms of women with endometriosis with a favourable tolerability and safety profile. Its effects on MK, a growth factor that plays an important role in
Nirgianakis, K, GRANDI, GIOVANNI, Mckinnon, B., Bersinger, N., CAGNACCI, Angelo, Mueller, M.   +5 more
openaire   +8 more sources

Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis

Arthritis Research & Therapy, 2018
Background Systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) is one of the leading causes of death in SSc. Identification of a serum-based proteomic diagnostic biomarker for SSc-PAH would allow for rapid non-invasive screening and ...
Lisa M. Rice, Julio C. Mantero, Eric A. Stratton, Rod Warburton, Kari Roberts, Nicholas Hill, Robert W. Simms, Robyn Domsic, Harrison W. Farber, Robert Layfatis   +9 more
doaj   +1 more source

Study of three novel biomarkers, MR-proADM, midkine, and stromelysin2, and peripheral atherosclerosis in a Chinese Han population: A case-control study

European Journal of Inflammation, 2020
Midregional pro-adrenomedullin (MR-proADM), midkine, and stromelysin2 (ST2) are novel cardiac biomarkers associated with heart failure and atherosclerotic diseases like stable ischemic disease and acute coronary syndrome.
Zhong Chen, Yawen Zhu, Lili Zhang
doaj   +1 more source