Immunohistochemical expression of proliferation markers in canine osteosarcoma [PDF]
Iraqi Journal of Veterinary Sciences, 2022 Canine osteosarcoma is an extremely malignant bone tumor that often arises in the bones of the limbs. It is a highly metastatic disease distinguished by proliferative bone lesions and a tendency for pulmonary metastasis.
Waseem H. Al-Jameel +3 more
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Immunohistochemical detection of P53 and MDM2 and its correlation with histological grading system in ovine pulmonary adenocarcinoma [PDF]
Iraqi Journal of Veterinary Sciences, 2021 Ovine pulmonary adenocarcinoma (OPA) is a cancer disease in sheep caused by Jaagsiekte sheep retrovirus (JSRV). The retrovirus is distinctive among viruses for inducing carcinogenesis of lung epithelial cells and cause a lung adenocarcinoma.
Enas S. Mustafa +2 more
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PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective
Acta Materia Medica, 2022 Mouse double minute 2 (MDM2) is an oncogenic E3 ligase that effectively degrades the tumor suppressor p53. In the past two decades, many MDM2 inhibitors that disrupt MDM2-p53 binding have been discovered and developed.
Xin Han, Wenyi Wei, Yi Sun
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Correlation between p53 and Mdm2 expression with histopathological parameters in cattle squamous cell carcinomas [PDF]
Veterinary World, 2022 Background and Aim: Squamous cell carcinoma (SCC) is the most common form of carcinoma in cattle. Histopathological grading systems have been utilized over several decades for estimating the malignancy of cattle SCCs.
Waseem Al-Jameel +2 more
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Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator. [PDF]
PLoS ONE, 2013 Human cancers over-expressing mdm2, through a T to G variation at a single nucleotide polymorphism at position 309 (mdm2 SNP309), have functionally inactivated p53 that is not effectively degraded.
Danielle R Okoro +6 more
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Cancer Biology & Medicine, 2021 Objective: FGFR is considered an important driver gene of lung squamous cell carcinoma (LSCC). Thus, identification of the biological events downstream of FGFR is important for the treatment of this malignancy.
Tao Chen +9 more
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Histopathology and Immunohistochemistry of tumors in animals attending veterinary teaching hospital [PDF]
Iraqi Journal of Veterinary Sciences, 2022 We aim in the current study to investigate the pathology and incidence of tumors that are excised surgically in Veterinary Teaching Hospital. This study collected the tissue samples from animals from 1 October 2020 until 1 April 2021.
Saevan S. Al-Mahmood +2 more
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Immunohistochemical Study of MDM2 Expression in Odontogenic Keratocyst and Dentigerous Cyst [PDF]
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2023 Introduction: Dentigerous cyst and odontogenic keratocyst (OKC) are two of the most common developmental odontogenic cysts. Different developmental mechanism and biological behavior of OKC is due to unknown factors inherent in the epithelium or enzymatic
Najmeh Jafari +2 more
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Indian Journal of Pathology and Microbiology, 2022 Background: Liposarcomas including atypical lipomatous tumors (ALT)/well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPSs) display a histomorphological spectrum with their several diagnostic mimics.
Bharat Rekhi +4 more
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Analysis of dedifferentiated liposarcomas emphasizing the diagnostic dilemmas
Indian Journal of Medical and Paediatric Oncology, 2020 Introduction: Dedifferentiated liposarcoma (DDLPS) is defined as a progression of well-differentiated liposarcoma (WDLPS) to another nonlipogenic sarcoma. Since a variety of heterologous sarcomas can be encountered in dedifferentiation, clinical dilemmas
Bhagat Singh Lali +4 more
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