The Functional Roles of the MDM2 Splice Variants P2-MDM2-10 and MDM2-∆5 in Breast Cancer Cells
Translational Oncology, 2017 BACKGROUND: MDM2 is a negative regulator of p53 and is upregulated in numerous human cancers. While different MDM2 splice variants have been observed in both normal tissues and malignant cells, their functions are poorly understood. METHODS: We evaluated
Johanna Huun +7 more
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Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells [PDF]
BMC Cell Biology, 2017 Background The murine double minute 2 (MDM2) is an oncogene and a negative regulator of the tumor suppressor protein p53. MDM2 is known to be amplified in numerous human cancers, and upregulation of MDM2 is considered to be an alternative mechanism of ...
Johanna Huun +6 more
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Immunohistochemical expression of proliferation markers in canine osteosarcoma [PDF]
Iraqi Journal of Veterinary Sciences, 2022 Canine osteosarcoma is an extremely malignant bone tumor that often arises in the bones of the limbs. It is a highly metastatic disease distinguished by proliferative bone lesions and a tendency for pulmonary metastasis.
Waseem H. Al-Jameel +3 more
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Immunohistochemical detection of P53 and MDM2 and its correlation with histological grading system in ovine pulmonary adenocarcinoma [PDF]
Iraqi Journal of Veterinary Sciences, 2021 Ovine pulmonary adenocarcinoma (OPA) is a cancer disease in sheep caused by Jaagsiekte sheep retrovirus (JSRV). The retrovirus is distinctive among viruses for inducing carcinogenesis of lung epithelial cells and cause a lung adenocarcinoma.
Enas S. Mustafa +2 more
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PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective
Acta Materia Medica, 2022 Mouse double minute 2 (MDM2) is an oncogenic E3 ligase that effectively degrades the tumor suppressor p53. In the past two decades, many MDM2 inhibitors that disrupt MDM2-p53 binding have been discovered and developed.
Xin Han, Wenyi Wei, Yi Sun
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Correlation between p53 and Mdm2 expression with histopathological parameters in cattle squamous cell carcinomas [PDF]
Veterinary World, 2022 Background and Aim: Squamous cell carcinoma (SCC) is the most common form of carcinoma in cattle. Histopathological grading systems have been utilized over several decades for estimating the malignancy of cattle SCCs.
Waseem Al-Jameel +2 more
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Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator. [PDF]
PLoS ONE, 2013 Human cancers over-expressing mdm2, through a T to G variation at a single nucleotide polymorphism at position 309 (mdm2 SNP309), have functionally inactivated p53 that is not effectively degraded.
Danielle R Okoro +6 more
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Genes & Cancer, 2012 While the presence, in the invertebrates, of genes related in sequence and function to the vertebrate p53 family has been known since the discovery of the fly Drosophila melanogaster Dmp53 and the worm Caenorhabditis elegans cep-1 gene, the failure to discover homologs of the essential vertebrate negative regulator of p53 Mdm2 in these species led to ...
David P, Lane, Chandra, Verma
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Cancer Biology & Medicine, 2021 Objective: FGFR is considered an important driver gene of lung squamous cell carcinoma (LSCC). Thus, identification of the biological events downstream of FGFR is important for the treatment of this malignancy.
Tao Chen +9 more
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Histopathology and Immunohistochemistry of tumors in animals attending veterinary teaching hospital [PDF]
Iraqi Journal of Veterinary Sciences, 2022 We aim in the current study to investigate the pathology and incidence of tumors that are excised surgically in Veterinary Teaching Hospital. This study collected the tissue samples from animals from 1 October 2020 until 1 April 2021.
Saevan S. Al-Mahmood +2 more
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