Results 31 to 40 of about 63,224 (282)
Methoxyphenyl Imidazolines as Potential Activators of p53
Medical Sciences Forum, 2022 The use of p53-MDM2/X inhibitors is a prospective strategy in anti-cancer therapy for tumors with wild type p53 protein. In our study, new low-molecular-weight inhibitors of the p53-mdm2 interaction have been proposed.
Daniil R. Bazanov +3 more
doaj +1 more source
Proteomic investigation of the MDM2 interactome and linear motif interactions [PDF]
, 2011 The oncoprotein MDM2 has an integral role in cancer development via multiple signalling pathways. Two proteomic mass spectrometry screens, label-free with spectral counting quantitation and 8-plex iTRAQ were used to identify proteins up or downregulated ...
Nicholson, Judith
core +3 more sources
Forum of Clinical Oncology, 2023 Liposarcomas are malignant mesenchymal neoplasms that, although derived from adipocytes, may dedifferentiate to other cell types. We present an exceedingly rare case of epithelioid/neuroendocrine dedifferentiation with somatostatin expression of a ...
Gaggero Gabriele +4 more
doaj +1 more source
Zhongliu Fangzhi Yanjiu, 2019 Objective To investigate CircHIPK3 expression in esophageal squamous cell carcinoma (ESCC) tissues, so as to find a new way of diagnosis and targeted therapy. Methods qRT-PCR, CCK-8, Transwell and flow cytometry were performed to detect the difference of
GOU Yunjiu +6 more
doaj +1 more source
Вавиловский журнал генетики и селекции, 2022 The risk of cervical cancer is caused by persistent human papillomavirus (HPV) infection. Cervical cancer is the most frequent cancer among women. Our purpose was to investigate the association between TP53 215C>G (Pro72Arg), MDM2 -410T>G, and NQO1
A.H. AlBosale, E. V. Mashkina
doaj +1 more source
Understanding the Effect of Natural Products on Breast Cancer via P53-MDM 2 Signal Pathway [PDF]
Journal of Cell and Molecular Research, 2021 The use of medicinal plants in the treatment of diseases has a long history dating back to the presence of humans on earth. Cancer has almost been an incurable disease, and among the various cancers, breast cancer is the most common type of cancer among ...
Zahra Ghavidel +3 more
doaj +1 more source
The mechanisms of regulation of Hdm2 protein level by serum growth factors [PDF]
, 2006 Cell cycle progression in response to serum growth factors is dependent on the expression of functional Hdm2 (Mdm2), which inhibits p53-dependent transcription of anti-proliferative genes.
Blaydes, Jeremy P. +5 more
core +1 more source
BioMolecular Concepts, 2013 Abstract MDM2 is an oncoprotein that blocks p53 tumor suppressor-mediated transcriptional transactivation, escorts p53 from the cell nucleus to the cytoplasm, and polyubiquitylates p53. Polyubiquitylated p53 is rapidly degraded in the cytoplasm by the 26S proteasome. MDM2 is abnormally upregulated in several types
Mendoza Michael +2 more
openaire +3 more sources
Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function
Life Science Alliance, 2022 This study shows that MDM2 acidic and zinc finger regions weakly interact with the RING domain and a fragment of p14ARF strengthens this interaction to inhibit MDM2 ubiquitin ligase activity.
Dominika Kowalczyk +3 more
doaj +1 more source
p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation [PDF]
Molecular Cell, 1998 Control of p53 turnover is critical to p53 function. E1A binding to p300/CBP translates into enhanced p53 stability, implying that these coactivator proteins normally operate in p53 turnover control. In this regard, the p300 C/H1 region serves as a specific in vivo binding site for both p53 and MDM2, a naturally occurring p53 destabilizer.
Grossman, Steven R +8 more
openaire +2 more sources