Results 1 to 10 of about 61,476 (246)

Comprehensive Analysis Revealed That CDKN2A Is a Biomarker for Immune Infiltrates in Multiple Cancers

Frontiers in Cell and Developmental Biology, 2021
The CDKN2A (cyclin dependent kinase inhibitor 2A/multiple tumor suppressor 1) gene, also known as the P16 gene, encodes multiple tumor suppressor 1 (MTS1), which belongs to the INK4 family.
Quan Zou, Yingjie Guo, Da Zhao
exaly   +3 more sources

Co-Occurrence of CDKN2A/B and IFN-I Homozygous Deletions Correlates With an Immunosuppressive Phenotype and Poor Prognosis in Lung Adenocarcinoma

Molecular Oncology, 2022
Homozygous deletion (HD) of CDKN2A and CDKN2B (CDKN2A/BHD) is the most frequent copy‐number variation (CNV) in lung adenocarcinoma (LUAD). CDKN2A/BHD has been associated with poor outcomes in LUAD; however, the mechanisms of its prognostic effect remain ...
Liyan Ji, Pansong Li, Zhenzhou Yang
exaly   +2 more sources

Transcriptomic Analysis Identifies CDKN2A-Associated Transcriptional Alterations in Primary Melanocytes of Lueyang Black-Boned Chicken [PDF]

Animals
Pronounced melanin enrichment characterizes the Lueyang black-boned chicken, yet the transcriptional basis underlying this pigmentation phenotype remains incompletely understood.
Fan Li, Zhi Cao, Qimeng Zhang, Wei Han, Longbing Yang, Jiuzhou Song, Qian Xue, Kai Jin   +7 more
doaj   +2 more sources

Association of CDKN2A overexpression with poor prognosis, radioresistance, and immunosuppression in colorectal cancer [PDF]

Frontiers in Cell and Developmental Biology
BackgroundIn colorectal cancer (CRC), dysregulated cyclin-dependent kinase inhibitor 2A (CDKN2A) contributes to disease progression. This investigation sought to explore the link between CDKN2A expression and the effectiveness of radiotherapy in CRC, and
Yaobin Lin, Zhihong Wang, Gaoda Ju, Yueying Zhang, Zongwei Huang, Shan Liu, Benhua Xu, Zhao Zhan   +7 more
doaj   +2 more sources

CDKN2A Deletion Leading to Hematogenous Metastasis of Human Gastric Carcinoma

Frontiers in Oncology, 2021
IntroductionSomatic copy number deletion (SCND) of CDKN2A gene is the most frequent event in cancer genomes. Whether CDKN2A SCND drives human cancer metastasis is far from clear.
Dajun Deng, Jiafu Ji, Jing Zhou
exaly   +3 more sources

The prognostic significance of p16 expression pattern in diffuse gliomas [PDF]

Journal of Pathology and Translational Medicine, 2021
Background CDKN2A is a tumor suppressor gene that encodes the cell cycle inhibitor protein p16. Homozygous deletion of the CDK-N2A gene has been associated with shortened survival in isocitrate dehydrogenase (IDH)–mutant gliomas.
Jin Woo Park, Jeongwan Kang, Ka Young Lim, Hyunhee Kim, Seong-Ik Kim, Jae Kyung Won, Chul-Kee Park, Sung-Hye Park   +7 more
doaj   +1 more source

Methylation of F2RL3, CDKN2A genes and sudden cardiac death

Атеросклероз, 2022
The aim of the study was to evaluate the association of methylation of the F2RL3, CDKN2A gene with sudden cardiac death (SCD). Material and methods. Case-control study design.
Anastasiya A. Ivanova, Anna A. Gurazheva, Sofya V. Maksimova, Sofya K. Malyutina, Vladimir P. Novoselov, Vladimir N. Maksimov   +5 more
doaj   +1 more source

Phenotypic and Genetic Features that Differ Between Hereditary and Sporadic Melanoma: Results of a Preliminary Study from a Single Center from Turkey

Dermatology Practical & Conceptual, 2023
Introduction: We have observed that most cutaneous melanoma patients under our supervision lack characteristic phenotypical features for melanoma. In contrast; history of cancers other than melanoma and age at onset before 50 were common.
Aysel Çakır, Gonca Elcin, Saadettin Kilickap, Özay Gököz, Zihni Ekim Taskiran, İsmail Celik   +5 more
doaj   +1 more source

Detection of somatic copy number deletion of the CDKN2A gene by quantitative multiplex PCR for clinical practice

Frontiers in Oncology, 2022
BackgroundA feasible method to detect somatic copy number deletion (SCND) of genes is still absent to date.MethodsInterstitial base-resolution deletion/fusion coordinates for CDKN2A were extracted from published articles and our whole genome sequencing ...
Yuan Tian, Jing Zhou, Juanli Qiao, Zhaojun Liu, Liankun Gu, Baozhen Zhang, Youyong Lu, Rui Xing, Dajun Deng   +8 more
doaj   +1 more source

ASSOCIATION OF CERTAIN SINGLE NUCLEOTIDE POLYMORPHISM GENES OF APOPTOSIS SYSTEM WITH A RISK OF DEVELOPMENT OF COLORECTAL CANCER IN RUSSIAN POPULATION

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Aim. Study the effect of single nucleotide polymorphism genes TP53 (rsl042522, rsl 800371), CDKN2A (rs3731217, rs3088440) and MDM2 (rs2279744) on the risk of development of colorectal cancer (CRC) in population of Perm Region. Materials and methods. Case
M. Kh. Alyeva, S. Ya. Zverev, I. V. Feldblyum, E. Yu. Noskova, A. O. Kanina, N. I. Markovich   +5 more
doaj   +1 more source