Results 21 to 30 of about 61,476 (246)
Gene-Level Associations in Patients With and Without Pathogenic Germline Variants in CDKN2A and Pancreatic Cancer
, 2022 Pancreatic ductal adenocarcinoma (PDAC) is a component of familial melanoma due to germline pathogenic variants (GPVs) in CDKN2A. However, it is unclear what role this gene or other genes play in its etiology.PURPOSE Pancreatic ductal adenocarcinoma ...Stefania Sciallero, Douglas R. Stewart, Margaret A. Tucker, Hildur Helgadottir, Joshua N. Sampson, Lorenza Pastorino, Bin Zhu, Belynda Hicks, Maria Teresa Landi, Amy Hutchinson, Cole Graham, Paola Queirolo, Alisa M. Goldstein, Remco van Doorn, Giuseppe Fornarini, Susana Puig, Veronica Höiom, Esteban Astiazaran-Symonds, Kristine Jones, Christian Ingvar, Neal D. Freedman, William Bruno, Jung Kim, Stephen J. Chanock, Nelleke Gruis, Paola Ghiorzo, Brian Carter, Xiaohong R. Yang, Sampson, JN, Pastorino, L, Ingvar, C, Zhu, B, Helgadottir, H,, Graham, C, Tucker, MA, Kim, J, Astiazaran-Symonds, E, van, Doorn R +37 morecore +1 more sourceImpact of PCSK9, WDR12, CDKN2A, and CXCL12 Polymorphisms in Jordanian Cardiovascular Patients on Warfarin Responsiveness and Sensitivity
International Journal of General Medicine, 2021 Rasheed K Ibdah,1 Laith N AL-Eitan,2 Nasr N Alrabadi,3 Ayah Y Almasri,2 Adan H Alnaamneh,2 Rame H Khasawneh,4 Mansour A Alghamdi5,6 1Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology,Ibdah RK, AL-Eitan LN, Alrabadi NN, Almasri AY, Alnaamneh AH, Khasawneh RH, Alghamdi MA +6 moredoaj Germline CDKN2A/P16INK4A mutations contribute to genetic determinism of sarcoma [PDF]
, 2017 Background Sarcomas are rare mesenchymal malignancies whose pathogenesis is poorly understood; both environmental and genetic risk factors could contribute to their aetiology.Koscielny, Serge, Mann, GJ, Stoppa-Lyonnet, D, N'Diaye, Birama, Caron, O., Daniel Pissaloux, Julia Newton-Bishop, Jouenne, F, Philippe Terrier, N'Diaye, B, Velghe, Amélie, Avril, Marie-Francoise, Cabaret, Odile, Barrett, Jennifer H, Demoulin, J.B., Caumette, Vincent, Avril, M.F., Terrier, Philippe, Lecesne, A., Serge Koscielny, Benuisiglio, Patrick, Scoazec, J-Y, Gauthier-Villars, Marion, Pissaloux, D., Lecesne, A, Eggermont, Alexander M, Brigitte Bressac-de Paillerets, Mann, Graham J, Jean-Baptiste Demoulin, Benusiglio, P., Newton-Bishop, J, Bressac-de Paillerets, B, Amélie Velghe, Caron, Olivier, Terrier, P, Velghe, A, Tchertanov, Luba, Bressac-de Paillerets, B., Rosine Guimbaud, Scoazec, Jean Yves, Harland, M, N'Diaye, B., Feunteun, J, Axel Lecesne, Patrick Benusiglio, Newton-Bishop, J., Bollaert, Emeline, Frebourg, Thierry, Coupier, Isabelle, Bougeard, G, Frebourg, T, Birama N’Diaye, Velghe, A., Jouenne, Fanélie, Bollaert, E, Demoulin, J-B, Tchertanov, L, Pissaloux, Daniel, Chauvot de Beauchene, I, Tchertanov, L., Pissaloux, D, Cabaret, O, Feunteun, J., Vincent Caumette, Gaelle Pierron, Bressac de Paillerets, Brigitte, Eggermont, A.M., Fanélie Jouenne, Koscielny, S., Graham J Mann, Arnaud de la Fouchardière, Jean-Yves Scoazec, Scoazec, J.Y., Caumette, V, Van Doorn, R, Gruis, N., Bougeard, G., Chauvot de Beauchêne, Isaure, Ingster, Olivier, Delnatte, C., Terrier, P., Olivier Ingster, Mann, Graham, J., Caumette, V., Barrett, J.H., Avril, M-F, Marion Gauthier-Villars, Isabelle Coupier, Guimbaud, R, Pierron, G., Gauthier-Villars, M, Odile Cabaret, Remco Van Doorn, Benusiglio, Patrick, Alexander M Eggermont, Delnatte, C, Guimbaud, Rosine, van Doorn, Remco, Thierry Frebourg, Mann, Graham,, Emeline Bollaert, Jouenne, F., Jennifer H Barrett, Marie-Françoise Avril, Ingster, O., Mann, G.J., H. Barrett, Jennifer, Gruis, Nelleke, Stoppa-Lyonnet, D., Benusiglio, P, Frebourg, T., Fouchardiere, A. de la, Pierron, Gaelle, Demoulin, Jean-Baptiste, Barrett, JH, Capucine Delnatte, Pierron, G, Harland, Mark, Koscielny, S, Delnatte, Capucine, de la Fouchardière, A, Jean Feunteun, Coupier, I., Feunteun, Jean, Luba Tchertanov, Coupier, I, Ingster, O, Scoazec, Jean-Yves, Eggermont, Alexander, Bressac-de Paillerets, Brigitte, Bollaert, E., Beauchene, I.C. de, Doorn, R. van, Guimbaud, R., Caron, O, Isaure Chauvot de Beauchene, de La Fouchardiere, Arnaud, Olivier Caron, Bougeard, Gaëlle, Dominique Stoppa-Lyonnet, Lecesne, Axel, Gauthier-Villars, M., Nelleke Gruis, Gruis, N, Eggermont, AM, Stoppa-Lyonnet, Dominique, Mark Harland, Harland, M., Cabaret, O., Gaelle Bougeard, Newton-Bishop, Julia +150 morecore +1 more sourceThe Prognostic Value of FGFR3 Expression in Patients with T1 Non-Muscle Invasive Bladder Cancer
Cancer Management and Research, 2021 Danijel Sikic,1,2 Helge Taubert,1,2 Johannes Breyer,3 Markus Eckstein,2,4 Veronika Weyerer,2,4 Bastian Keck,1,2 Jennifer Kubon,1,2 Wolfgang Otto,3 Thomas S Worst,5 Maximilian C Kriegmair,5 Philipp Erben,5 Arndt Hartmann,2,4 Bernd Wullich,1,2 Ralph M ...Sikic D, Taubert H, Breyer J, Eckstein M, Weyerer V, Keck B, Kubon J, Otto W, Worst TS, Kriegmair MC, Erben P, Hartmann A, Wullich B, Wirtz RM, Wach S +14 moredoaj Childhood Acute B-Lineage Lymphoblastic Leukemia With CDKN2A/B Deletion Is a Distinct Entity With Adverse Genetic Features and Poor Clinical Outcomes
Frontiers in Oncology, 2022 To further emphasize the clinical–genetic features and prognosis of CDKN2A/B deletions in childhood acute lymphoblastic leukemia (ALL), we retrospectively analyzed 819 consecutive B-ALL patients treated with the Chinese Children’s Cancer Group ALL-2015 ...Jing Feng, Ye Guo, Wenyu Yang, Yao Zou, Li Zhang, Yumei Chen, Yingchi Zhang, Xiaofan Zhu, Xiaojuan Chen +8 moredoaj +1 more sourceIndication for CDKN2A-mutation analysis in familial pancreatic cancer families without melanomas [PDF]
, 2011 Background CDKN2A-mutation carriers run a high risk of developing melanomas and have an increased risk of developing pancreatic cancer (PC). Familial PC (FPC) patients with a personal history or family history of melanomas are therefore offered CDKN2A ...Rolf H. Sijmons, Harinck, F. (Femme), Kluijt, Irma, Sijmons, Rolf H., Stoep, N. (Nienke) van der, Nienke van der Stoep, van der Stoep, Nienke, Poley, Jan-Werner, Irma Kluijt, Rogier Oldenburg, Ernst J. Kuipers, Anja Wagner, Stoep, N. van der, Sijmons, R.H. (Rolf), Kuipers, E.J. (Ernst), Kuipers, E.J., van Os, TAM, Oldenburg, R.A. (Rogier), Aalfs, CM, Wagner, A., Bruno, Marco, Sijmons, RH, Kuipers, Ernst, Fockens, P, Harinck, F., Aalfs, Cora M., Wagner, Anja, Wagner, A. (Anja), Paul Fockens, Theo A. van Os, Harinck, Femme, Jan-Werner Poley, Kuipers, Ernst J., Kluijt, I. (Irma), Kluijt, I., Oldenburg, R.A., van Os, Theo A. M., Aalfs, C.M. (Cora), Os, T.A.M. (Theo) van, Bruno, M.J. (Marco), Poley, J.-W. (Jan-Werner), Oldenburg, Rogier A., Bruno, Marco J., Bruno, M.J., Femme Harinck, Cora M. Aalfs, Poley, J.W., Wagner, Anja; id_orcid, Fockens, P., van der Stoep, N, Aalfs, C.M., Oldenburg, Rogier, Kluijt, I, Sijmons, R.H., Fockens, P. (Paul), Marco J. Bruno, Os, T.A.M. van, Fockens, Paul +57 morecore +1 more sourceFunctional CDKN2A assay identifies frequent deleterious alleles misclassified as variants of uncertain significance
eLife, 2022 Pathogenic germline CDKN2A variants are associated with an increased risk of pancreatic ductal adenocarcinoma (PDAC). CDKN2A variants of uncertain significance (VUSs) are reported in up to 4.3% of patients with PDAC and result in significant uncertainty ...Hirokazu Kimura, Raymond M Paranal, Neha Nanda, Laura D Wood, James R Eshleman, Ralph H Hruban, Michael G Goggins, Alison P Klein, The Familial Pancreatic Cancer Genome Sequencing Project, Nicholas J Roberts +9 moredoaj +1 more sourceAssociation between early risk factors and CDKN2A/B deletion in pediatric patients with acute lymphoblastic leukemia in a pediatric cancer center in Colombia
Pediatric Hematology Oncology Journal, 2022 Cyclin dependent kinase inhibitor (CDKN) 2A/B deletion is correlated with poor risk factors, such as high blood cell count, higher rate of induction therapy failure, and earlier relapses in pediatric patients with acute lymphoblastic leukemia (ALL).Cindy Martinez, Luz Karime Yunis, Edgar Cabrera, Johnny García, Gloria Uribe, Edna Quintero, Juan Jose Yunis, Adriana Linares Ballesteros, Isabel Cristina Sarmiento +8 moredoaj +1 more source
