Results 41 to 50 of about 61,476 (246)
Mutation analysis of the CDKN2A promoter in Australian melanoma families
, 2001 Approximately 50% of all melanoma families worldwide show linkage to 9p21-22, but only about half of these have been shown to contain germ line CDKN2A mutations.
Martin, N. G. +14 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 1999 Loss of CDKN2A expression was demonstrated by immunohistochemistry in 87% of oral and oropharyngeal squamous cell carcinoma (OSCC) primary tumor samples. By contrast, DNA studies showed a much lower frequency of loss of the CDKN2A gene.
Paterson, Ian +10 more
core +5 more sources
European Journal of BiologyObjective: Currently, treating triple-negative breast cancer (TNBC) poses a significant challenge. Eryngium billardierei is widely employed as a medicinal plant, particularly for the treatment of cancers.
Azadeh Hekmat +2 more
doaj +1 more source
, 2014 A) CDKN2A encoding p16 plays a significant role in the cell cycle by regulating the initiation of DNA replication. A simplified diagram shows select genes that play a major role in the cell cycle.
John P. Fahrenbach (358919) +2 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
mRNA-lncRNA gene expression signature in HPV-associated neoplasia and cervical cancer
Вавиловский журнал генетики и селекцииCervical cancer is one of the most frequent cancers in women and is associated with human papillomavirus (HPV) in 70 % of cases. Cervical cancer occurs because of progression of low-differentiated cervical intraepithelial neoplasia through grade 2 and 3 ...
E. D. Kulaeva +2 more
doaj +1 more source
Patient characteristics stratified by TP53 and CDKN2A mutations.
, 2020 Patient characteristics stratified by TP53 and CDKN2A mutations.
Mahesh Seetharam (8605005) +17 more
core +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Food Materials ResearchCultured meat represents a promising alternative for future meat consumption. However, the progress of research and industrialization has been hindered by the absence of serum-free media capable of supporting the long-term expansion of specific cells ...
Renpeng Guo +8 more
doaj +1 more source