Results 51 to 60 of about 61,476 (246)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Next-generation sequencing identifies CDKN2A alterations as prognostic biomarkers in recurrent or metastatic head and neck squamous cell carcinoma predominantly receiving immune checkpoint inhibitors

Frontiers in Oncology, 2023
BackgroundThis study aimed to identify potential biomarkers in patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) and further probe the prognostic implications of CDKN2A mutations, particularly within a subset receiving ...
Liqiong Xue, Wenbo Tang, Jiuli Zhou, Junli Xue, Qun Li, Xiaoxiao Ge, Fengjuan Lin, Wei Zhao, Ye Guo   +8 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Ocular melanoma is not associated with CDKN2A or MC1R variants - a population-based study

, 2003
Germline variants in the melanocortin 1 receptor gene (MC1R) and the p16 gene (CDKN2A) are associated with an increased risk of cutaneous melanoma. The frequency of these germline variants was examined in a population-based, incident series of 62 ocular ...
C. Vajdica, B. K. Armstrongf, J. A. C. Ter Huurnee, Martin, NG, Hayward, NK, Kricker, A, M. Starkc, Melanoma Res, Vajdic, C, D. L. Duffyc, Aitken, JF, N. G. Martinc, Stark, M, ter Huurne, JAC, Duffy, DL, A. Krickerb, N. K. Haywardc, Armstrong, BK, J. F. Aitkend   +18 more
core   +2 more sources

Pre-transplant CDKN2A expression in kidney biopsies predicts renal function and is a future component of donor scoring criteria. [PDF]

PLoS ONE, 2013
CDKN2A is a proven and validated biomarker of ageing which acts as an off switch for cell proliferation. We have demonstrated previously that CDKN2A is the most robust and the strongest pre-transplant predictor of post-transplant serum creatinine when ...
Marc Gingell-Littlejohn, Dagmara McGuinness, Liane M McGlynn, David Kingsmore, Karen S Stevenson, Christian Koppelstaetter, Marc J Clancy, Paul G Shiels   +7 more
doaj   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans. [PDF]

, 2016
At the CDKN2A/B locus, three independent signals for type 2 diabetes risk are located in a non-coding region near CDKN2A. The disease-associated alleles have been implicated in reduced β-cell function, but the underlying mechanism remains elusive.
Pijl, H., Potjer, TP, McCarthy, MI, Pal, A., James, T.J., Thomsen, S.K., McCarthy, M.I., Potjer, T.P., Scharfmann, R., Newton-Bishop, J., Karpe, F, Vasen, HF, Gloyn, AL, Ng, HJ, Ng, H.J., Thomsen, SK, Scharfmann, R, Godsland, I.F., Gloyn, A.L., Karpe, F., Bishop, D.T., James, TJ, Barrett, A., Godsland, IF, Vasen, H.F.A., Bishop, DT, Barrett, A, Newton-Bishop, J, Pal, A, Pijl, H   +29 more
core   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Necroptosis-related genes are associated with prognostic features of kidney renal clear cell carcinoma

Discover Oncology, 2023
Introduction Renal clear cell carcinoma is a common type of cancer in the adult urological system. It has a high mortality rate, with 30% of patients developing metastasis and 60% dying within 1–2 years of diagnosis.
Yiduo Wang, Ke-Hao Pan, Ming Chen
doaj   +1 more source

Distinct Clinicogenomic Contexts of BRAF-Altered Gliomas and Glioneuronal Tumors: A Nationwide Real-World Study. [PDF]

Cancer Sci
Nationwide real‐world profiling revealed distinct clinicogenomic contexts across major BRAF alteration classes in gliomas and glioneuronal tumors. KIAA1549::BRAF fusion was associated with younger age and predominantly low‐grade tumors, whereas BRAF amplification‐only tumors were predominantly high‐grade and showed frequent MET amplification.
Yamada S, Takimoto T, Ueno S, Minamiguchi S, Ohba S, Hirose Y, Saya H, Sudo T.   +7 more
europepmc   +2 more sources