Results 51 to 60 of about 63,224 (282)

The role of MDM2 amplification and overexpression in therapeutic resistance of malignant tumors

Cancer Cell International, 2019
The MDM2 protein encoded by the mouse double minute 2 (MDM2) gene is the primary negative regulatory factor of the p53 protein. MDM2 can ligate the p53 protein via its E3 ubiquitin ligase, and the ubiquitinated p53 can be transferred to the cytoplasm and
Helei Hou, Dantong Sun, Xiaochun Zhang
doaj   +1 more source

Resistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them?

Cellular & Molecular Biology Letters, 2021
Since the discovery of the first MDM2 inhibitors, we have gained deeper insights into the cellular roles of MDM2 and p53. In this review, we focus on MDM2 inhibitors that bind to the p53-binding domain of MDM2 and aim to disrupt the binding of MDM2 to ...
Lucia Haronikova, Ondrej Bonczek, Pavlina Zatloukalova, Filip Kokas-Zavadil, Martina Kucerikova, Philip J. Coates, Robin Fahraeus, Borivoj Vojtesek   +7 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Inhibition of the MDM2/p53 Interaction Design, Synthesis and Evaluation of MDM2 Inhibitors [PDF]

, 2015
Numerous essential cellular processes are regulated by protein-protein interactions (PPIs) and PPIs have therefore been recognised as potential new drug targets. The transcription factor p53 is often referred to as the guardian of the genome due to its
Pettersson, Mariell
core   +1 more source

Resveratrol-derived MDM2 inhibitors: Synthesis, characterization, and biological evaluation against MDM2 and HCT-116 cells

Open Chemistry
This study investigates the biological potential of novel resveratrol-based derivatives targeting the MDM2 protein, a critical regulator of the tumour suppressor p53 in cancer therapy.
Oraibi Amjad Ibrahim, Dawood Ashour H., Debbabi Nawres, Almukram Ali Majeed Ali, Almaary Khalid S., Dabiellil Fakhreldeen, Chekir-Ghedira Leila, Kilani-Jaziri Soumaya   +7 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription [PDF]

, 2003
The transcription factor p53 lies at the center of a protein network that controls cell cycle progression and commitment to apoptosis. p53 is inactive in proliferating cells, largely because of negative regulation by the Hdm2/Mdm2 oncoprotein, with which
Darley, Matthew, Primrose, John N., Blaydes, Jeremy P., Campbell, Sandra J., Mirnezami, Alexander H., Alexander H. Mirnezami, Sandra J. Campbell, Jeremy P. Blaydes, Johnson, Peter W.M., Matthew Darley, John N. Primrose, Peter W.M. Johnson   +11 more
core   +1 more source

Role of the RING domain in MDM2-mediated ubiquitination of p53 [PDF]

, 2015
The MDM2 protein regulates the tumour suppressor protein p53, acting as its chaperone, regulating its translation and targeting p53 for degradation by the 26s proteasome via its E3 ligase activity.
Lickiss, Fiona
core   +3 more sources

Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction. [PDF]

PLoS ONE, 2012
The p53 transcription factor and tumor suppressor is regulated primarily by the E3 ubiquitin ligase Mdm2, which ubiquitinates p53 to target it for proteasomal degradation.
Hilary V Clegg, Yoko Itahana, Koji Itahana, Sundhar Ramalingam, Yanping Zhang   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source