Results 61 to 70 of about 63,224 (282)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Hinokiflavone Inhibits MDM2 Activity by Targeting the MDM2-MDMX RING Domain

Biomolecules, 2022
The proto-oncogene MDM2 is frequently amplified in many human cancers and its overexpression is clinically associated with a poor prognosis. The oncogenic activity of MDM2 is demonstrated by its negative regulation of tumor suppressor p53 and the substrate proteins involved in DNA repair, cell cycle control, and apoptosis pathways.
Viktoria K. Ilic, Olga Egorova, Ernest Tsang, Milena Gatto, Yi Wen, Yong Zhao, Yi Sheng   +6 more
openaire   +3 more sources

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3‐Mediated Transcriptional Inactivation of p53

Advanced Science, EarlyView.
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu, Jingyu Yu, Suhui Wang, Xinghong Hu, Lele Jin, Nan Wu, Yuhan Ni, Xueying Zhang, Chengling Zhao, Jihong Zhou, Yong Zhang, Baofa Sun, Hongxing Zhang, Chunfu Zheng, Song Guo Zheng, Wei Li, Xinxing Zhu   +16 more
wiley   +1 more source

Lactobacillus acidophilus ATCC4356 inhibits thyroid cancer via E3 ubiquitin-protein ligase Mdm2 (MDM2)

Türk Biyokimya Dergisi
Emerging evidence suggests that Lactobacillus species exhibit anticancer properties against various malignancies, including gastric and breast cancers. However, their effects on thyroid cancer remain unexplored.
Ke Rui-Sheng, Zhang Wei-Hao, Tu Yan-ling, Liu Zhao-Hui, Zhang Fu-Xing, Huang Kun-Zhai   +5 more
doaj   +1 more source

Anticancer activity of Aucklandia costus Falc. terpenes: Targeting MDM2 protein inhibition for therapeutic advancements [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Protein 53 (p53) is a well-known tumor suppressor protein, while murine double minute 2 (MDM2) acts as a negative regulator of p53, leading to p53 inactivation and cancer development. Aucklandia costus Falc. or Saussurea lappa contains bioactive
Theresia Indah Budhy, Ira Arundina, Anis Irmawati, Sidarningsih, Meircurius Dwi Condro Surboyo, Cecillia Octavianni Raharjo, Ciptantyo Septyan Akbar, Malika Qadira Rahmalia   +7 more
doaj   +1 more source

S100A1 Promotes MDM2-Mediated KLF15 Ubiquitination to Regulate ID1-Driven Tubular Injury in Diabetic Kidney Disease. [PDF]

FASEB J
High glucose upregulates S100A1, enhancing MDM2–KLF15 interaction and K48‐linked ubiquitination of KLF15. Degradation of KLF15 relieves ID1 repression, promoting ID1 upregulation, inflammation, fibrosis, tubular injury, and DKD progression. ABSTRACT Diabetic kidney disease (DKD) is the leading cause of end‐stage renal disease globally.
Zeng Z, Shang J, Chai S, Zhang X, Lv X, Han X, Xu Y, Ma B, Lv Z, Wang R.   +9 more
europepmc   +2 more sources

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

ASSOCIATION OF CERTAIN SINGLE NUCLEOTIDE POLYMORPHISM GENES OF APOPTOSIS SYSTEM WITH A RISK OF DEVELOPMENT OF COLORECTAL CANCER IN RUSSIAN POPULATION

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Aim. Study the effect of single nucleotide polymorphism genes TP53 (rsl042522, rsl 800371), CDKN2A (rs3731217, rs3088440) and MDM2 (rs2279744) on the risk of development of colorectal cancer (CRC) in population of Perm Region. Materials and methods. Case
M. Kh. Alyeva, S. Ya. Zverev, I. V. Feldblyum, E. Yu. Noskova, A. O. Kanina, N. I. Markovich   +5 more
doaj   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source