Results 81 to 90 of about 64,512 (289)

c-Abl Phosphorylation of Mdm2 Facilitates Mdm2-Mdmx Complex Formation [PDF]

Journal of Biological Chemistry, 2011
Mdm2 and Mdmx are oncoproteins that have essential yet nonredundant roles in development and function as part of a multicomponent ubiquitinating complex that targets p53 for proteasomal degradation. However, in response to DNA damage, Mdm2 and Mdmx are phosphorylated and protect p53 through various mechanisms.
David L, Waning, Jason A, Lehman, Christopher N, Batuello, Lindsey D, Mayo   +3 more
openaire   +2 more sources

Effect of serum miRNA6089 level on melanocyte function in vitiligo patients

徐州医科大学学报
Objective To observe the impact of miRNA6089 on the function of melanocytes and provide the genetic evidence of miRNA in regulating melanocytes to participate in the disease process of vitiligo.
ZHAO Ya'nan, ZENG Mingfeng, LUO Dong, ZHANG Jingzhan, HU Wen, DING Yuan, KANG Xiaojing   +6 more
doaj   +1 more source

Human MDM2 promotes ORF50 degradation.

, 2016
(A) Effect of MDM2 expression on ORF50 abundance. Increasing amounts of an MDM2 expression plasmid, pCMV6-XL-MDM2, were cotransfected with a plasmid expressing F-ORF50, F-590 or F-390 in 293T, 293 or HKB5/B5 cells.
Ying-Ju Shih (3188985), Li-Kwan Chang (12818), Tzu-Hsuan Chang (1847365), Lee-Wen Chen (3188979), Shih-Tung Liu (12823), Shie-Shan Wang (3188982), Pey-Jium Chang (479322)   +6 more
core   +1 more source

Inhibition of the MDM2/p53 Interaction Design, Synthesis and Evaluation of MDM2 Inhibitors [PDF]

, 2014
Numerous essential cellular processes are regulated by protein-protein interactions (PPIs) and PPIs have therefore been recognised as potential new drug targets. The transcription factor p53 is often referred to as the guardian of the genome due to its
Pettersson, Mariell, Grøtli, Morten,, Bliman, David,, Pettersson, Mariell,, Bood, Mattias,   +4 more
core   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

The p53/Mdm2 Pathway in Hepatocellular Carcinoma: From Molecular Pathogenesis to Targeted Therapies

Livers
Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and accounts for over 800,000 deaths worldwide, making it a major global health concern.
Keara Kirkness, Derek A. Mann
doaj   +1 more source

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source

A Protein in the Yeast Saccharomyces cerevisiae Presents DNA Binding Homology to the p53 Checkpoint Protein and Tumor Suppressor

Biomolecules, 2020
Saccharomyces cerevisiae does not contain a p53 homolog. Utilizing this yeast as an in vivo test tube model, our aim was to investigate if a yeast protein would show p53 DNA binding homology. Electrophoretic mobility shift analyses revealed the formation
Kanwal Farooqi, Marjan Ghazvini, Leah D. Pride, Louis Mazzella, David White, Ajay Pramanik, Jill Bargonetti, Carol Wood Moore   +7 more
doaj   +1 more source

Both MDM2 and MDM2(C464A) inhibit Axin-HIPK2 interaction.

, 2013
(A, B) HEK 293T cells were co-transfected with Axin, HA-HIPK2 and Myc-MDM2 or MDM2 (C464A) as indicated, followed by immunoprecipitation and western blotting analysis.
Ying He (125930), Qinxi Li (427967), Guili Lian (427964), Zhiyun Ye (427966), Shuyong Lin (427965)   +4 more
core   +1 more source

CRISPR‐Scan: Cas13a Mismatch Tolerance Enabled Ultra‐Multiplexed Detection of Same‐Site Indels in Acute Myeloid Leukemia

Advanced Science, EarlyView.
Accurately detecting diverse same‐locus insertions or deletions (indels) remains challenging. This study reveals the mismatch‐tolerance profile of LwaCas13a and establishes CRISPR‐Scan, which uses a single crRNA to detect multiple same‐locus indels. The one‐pot assay detects nucleophosmin 1 (NPM1) mutant allele frequencies down to 0.01%, agrees with ...
Linlin Bai, Bei Wang, Mingmin Shi, Dianwei Liu, Huimin Ji, Ting Wang, Ziwei Wang, Kaiming Guo, Xinyang Dou, Chunyan Qian, Fang Zhang, Yongming Wang, Hongju Mao, Rui Wang   +13 more
wiley   +1 more source