Results 81 to 90 of about 63,224 (282)

c-Abl Phosphorylation of Mdm2 Facilitates Mdm2-Mdmx Complex Formation [PDF]

Journal of Biological Chemistry, 2011
Mdm2 and Mdmx are oncoproteins that have essential yet nonredundant roles in development and function as part of a multicomponent ubiquitinating complex that targets p53 for proteasomal degradation. However, in response to DNA damage, Mdm2 and Mdmx are phosphorylated and protect p53 through various mechanisms.
David L, Waning, Jason A, Lehman, Christopher N, Batuello, Lindsey D, Mayo   +3 more
openaire   +2 more sources

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

The p53/Mdm2 Pathway in Hepatocellular Carcinoma: From Molecular Pathogenesis to Targeted Therapies

Livers
Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and accounts for over 800,000 deaths worldwide, making it a major global health concern.
Keara Kirkness, Derek A. Mann
doaj   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Effect of serum miRNA6089 level on melanocyte function in vitiligo patients

徐州医科大学学报
Objective To observe the impact of miRNA6089 on the function of melanocytes and provide the genetic evidence of miRNA in regulating melanocytes to participate in the disease process of vitiligo.
ZHAO Ya'nan, ZENG Mingfeng, LUO Dong, ZHANG Jingzhan, HU Wen, DING Yuan, KANG Xiaojing   +6 more
doaj   +1 more source

Exosomal lncRNA CHL1-AS1 Derived from Peritoneal Macrophages Promotes the Progression of Endometriosis via the miR-610/MDM2 Axis

International Journal of Nanomedicine, 2021
Ting Liu,1 Mei Liu,2 Caihua Zheng,3 Daoyan Zhang,4 Mingbao Li,1 Lu Zhang1 1Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, 250012, People’s Republic of China; 2Department of Obstetrics, Affiliated Hospital of ...
Liu T, Liu M, Zheng C, Zhang D, Li M, Zhang L   +5 more
doaj  

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

Supplementary Figure 1 from Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma

, 2009
Supplementary Figure 1 from Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in ...
Dana-Lynn T. Koomoa (10030325), David J. Feith (8654346), Christopher J. Wallick (14973789), André S. Bachmann (12028280), Craig C. Coleman (15041754), Anthony E. Pegg (1266138), Tamas Borsics (15041751), Ivonne Gamper (6249365)   +7 more
core   +1 more source

MDM2-C Functions as an E3 Ubiquitin Ligase

Cancer Management and Research, 2020
Jun Yeob Kim,1 Rusia Lee,1,2 Gu Xiao,1 Dominique Forbes,1 Jill Bargonetti1– 3 1The Department of Biological Sciences, Hunter College, City University of New York, New York, NY, USA; 2Biology PhD Program, The Graduate Center of Biology, City ...
Kim JY, Lee R, Xiao G, Forbes D, Bargonetti J   +4 more
doaj  

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source