Results 91 to 100 of about 63,224 (282)

Supplementary Table 1 from Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma

, 2009
Supplementary Table 1 from Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in ...
Dana-Lynn T. Koomoa (10030325), David J. Feith (8654346), Christopher J. Wallick (14973789), André S. Bachmann (12028280), Craig C. Coleman (15041754), Anthony E. Pegg (1266138), Tamas Borsics (15041751), Ivonne Gamper (6249365)   +7 more
core   +1 more source

The Cellular p53 Inhibitor MDM2 and the Growth Factor Receptor FLT3 as Biomarkers for Treatment Responses to the MDM2-Inhibitor Idasanutlin and the MEK1 Inhibitor Cobimetinib in Acute Myeloid Leukemia. [PDF]

, 2018
The tumor suppressor protein p53 is inactivated in a large variety of cancer cells. Cellular p53 inhibitors like the mouse double minute 2 homolog (MDM2) commonly suppress the p53 function in acute myeloid leukemia (AML).
Miguel Marques, Miguel A. T. Marques, Sidler, Corinne, Pabst Müller, Thomas Niklaus, Mueller, Beatrice U, Katja Seipel, Beatrice U. Mueller, Corinne Sidler, Thomas Pabst, Seipel, Katja, Beatrice Mueller, Marques, Miguel A T   +11 more
core   +2 more sources

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

TBP-1 (TAT BINDING PROTEIN-1) IN THE CONTROL OF CELL PROLIFERATION: FUNCTIONAL RELATIONSHIP WITH THE AKT/PKB SIGNALING PATHWAY [PDF]

, 2011
TBP-1/Tat-Binding Protein 1 (also named Rpt-5, S6a or PSMC3) is a multifunctional protein, originally identified as a regulator of HIV-1-Tat mediated transcription.
Festa, Luisa
core   +1 more source

A Single Conserved Amino Acid Residue as a Critical Context-Specific Determinant of the Differential Ability of Mdm2 and MdmX RING Domains to Dimerize

Frontiers in Physiology, 2019
Mdm2 and MdmX are related proteins serving in the form of the Mdm2 homodimer or Mdm2/MdmX heterodimer as an E3 ubiquitin ligase for the tumor suppressor p53.
Pavlína Kosztyu, Iva Slaninová, Barbora Valčíková, Barbora Valčíková, Amandine Verlande, Amandine Verlande, Petr Müller, Jan J. Paleček, Jan J. Paleček, Stjepan Uldrijan, Stjepan Uldrijan   +10 more
doaj   +1 more source

A Multistrategy AI‐Assisted Consensus Screening Pipeline for Discovery of Candidate p53 Monomer Binders

Advanced Intelligent Discovery, EarlyView.
An ultra‐fast small‐sample AI consensus pipeline combines co‐folding and docking to target structure‐lacking p53 monomers. Its optimal mini‐protein binder shows robust interfacial affinity and promising druggability, supplying unprecedented antitumor p53 templates.
Ningyao Li, Xueyi Liu, Qiuyue Li, Chengfeng Yue, Xin Li, Yugang Huang, Xin Deng, Junfei Zhang, Xue Liang, Guodong Ye   +9 more
wiley   +1 more source

Comparative analysis of TP53 gene in Tupaia belangeri subspecies (Tupaia belangeri yaoshanensis vs. Tupaia belangeri chinensis) and identification of mutations in spontaneous tumor cases

Animal Models and Experimental Medicine, EarlyView.
This study provides the first evidence of natural TP53 variation between tree shrew subspecies and identifies somatic TP53 mutations in spontaneous tree shrew sarcomas. The high structural and functional conservation of tree shrew p53 with humans supports its utility as a relevant model for TP53‐related cancer research.
Yingying Cao, Haibo Tang, Liang Liang, Jing Leng, Weijian Huang   +4 more
wiley   +1 more source

Supplementary Figure 2 from Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma

, 2009
Supplementary Figure 2 from Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in ...
Dana-Lynn T. Koomoa (10030325), David J. Feith (8654346), Christopher J. Wallick (14973789), André S. Bachmann (12028280), Craig C. Coleman (15041754), Anthony E. Pegg (1266138), Tamas Borsics (15041751), Ivonne Gamper (6249365)   +7 more
core   +1 more source

Not all NTRK fusions in mesenchymal neoplasia are driver events: implications on classification and targeted therapy. [PDF]

J Pathol Clin Res
Abstract NTRK fusions drive the pathogenesis of a distinctive group of mesenchymal neoplasms with significant impact on classification and targeted therapy. However, unexpected NTRK fusions have been reported in other sarcoma entities, raising uncertainty over their specificity and clinical management.
Yakoub MA, Sukhadia P, Saoud C, Hameed M, Antonescu CR.   +4 more
europepmc   +2 more sources

Association of MDM2 Overexpression in Ameloblastomas with MDM2 Amplification and BRAFV600E Expression

International Journal of Molecular Sciences
Ameloblastoma is a rare tumor but represents the most common odontogenic neoplasm. It is localized in the jaws and, although it is a benign, slow-growing tumor, it has an aggressive local behavior and high recurrence rate. Therefore, alternative treatment options or complementary to surgery have been evaluated, with the most promising one among them ...
Konstantinos I. Tosios, Eleni-Marina Kalogirou, Ioannis G. Koutlas   +2 more
openaire   +3 more sources