Results 91 to 100 of about 64,512 (289)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

A potential mechanism for differential regulation of p53 transcriptional activity by wild-type Mdm2 and Mdm2^C462A.

, 2013
A) Heterodimerization between wild-type Mdm2 and Mdmx is necessary for inhibiting the p53-p300 interaction and suppressing p300-mediated acetylation of p53, reducing p53 activity.
Sundhar Ramalingam (321219), Yanping Zhang (153797), Yoko Itahana (321215), Koji Itahana (321217), Hilary V. Clegg (321213)   +4 more
core   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Role of MDM2 In Cell Growth Regulation [PDF]

, 2006
MDM2 has been shown to induce G0-Gl/S phase arrest. To determine the cell cycle step targeted by MDM2, flow cytometry was employed to detect induction of events during the G1-S phase transition in MDM2-arrested cells. MDM2 overexpression does not prevent
Frum, Rebecca Anne
core   +1 more source

NSUN3‐Associated m5C Modification of tRF5‐GlyTCC Suppresses Colorectal Cancer Progression via RPL23‐Linked Nucleolar Stress and p53‐Associated Autophagy and Enhances 5‐FU Sensitivity

Advanced Science, EarlyView.
This study identifies that NSUN3‐mediated m5C modification stabilizes tRF5‐GlyTCC, linking ribosomal homeostasis, nucleolar stress responses, and p53 signaling changes. This regulatory axis suppresses colorectal cancer and enhances chemotherapy response to 5‐FU, positioning tRF5‐GlyTCC as a potential therapeutic target for improving drug sensitivity in
Xinhui Lv, Can Tang, Feiyang Song, Yu Wu, Yafang Chen, Sicong Liu, Ziwen Yuan, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex [PDF]

, 2008
The tumour suppressor p53, which accumulates in re-sponse to DNA damage and induces cell-cycle arrest and apoptosis, has a key function in the maintenance of genome integrity.
Hyun Jung Oh, Song, Min Sup, Oh, Hyun Jung, Song, Su Jung, Lim, Dae-Sik, Min Sup Song, Su Jung Song, Dae-Sik Lim, Kim, So Yeon, So Yeon Kim   +9 more
core   +1 more source

DTX3 Suppresses the NPM3–RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance

Advanced Science, EarlyView.
Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao, Chang‐Jun Xie, Yan‐Hua Chen, Hao Cheng, Shuang‐Hui Li, Wei Li, Ya‐Wen Bin, Rui‐Min He, Ying‐Qing Li, Ping Feng   +9 more
wiley   +1 more source

Apoptosis as a factor for organizing autoimmune inflammation in rheumatoid arthritis

Современная ревматология, 2019
The paper summarizes the data available in the literature and those from the authors' studies on the molecular and cellular mechanisms of apoptosis and their state in rheumatoid arthritis (RA).
A. I. Dubikov, S. G. Kalinichenko, N. Yu. Matveeva   +2 more
doaj   +1 more source

miR-410 targets at MDM2 in GC cells.

, 2014
(A) The sequences of miR-410 binding sites within the human MDM2 3′UTRs and schematic reporter constructs, in this panel, c-MDM2-WT represent the reporter constructs containing the entire 3′UTR sequences of MDM2.
Ming Zhou (73279), Jun Ma (9393), Weina Niu (618067), Hongyan Zhang (618068), Jianjun Shen (231389), Ling Wang (56577), Hongbo Zhang (427842)   +6 more
core   +1 more source

Proteomic investigation of the MDM2 interactome and linear motif interactions [PDF]

, 2011
The oncoprotein MDM2 has an integral role in cancer development via multiple signalling pathways. Two proteomic mass spectrometry screens, label-free with spectral counting quantitation and 8-plex iTRAQ were used to identify proteins up or downregulated ...
Nicholson, Judith
core   +1 more source