Results 111 to 120 of about 64,512 (289)
Both MDM2 and MDM2 (C464A) disrupt Axin-p53 interaction by recruiting p53.
, 2013 (A) HEK 293T cells were transfected with 2 µg untagged Axin and increasing amounts (3 µg and 8 µg) of HA-MDM2, HA-MDM2 (C464A) or HA-MDM2Δp53. (B) HEK 293T cells were transfected with HA-Axin, FLAG-p53 and Myc-MDM2 or MDM2 (C464A) and analyzed by ...
Ying He (125930) +4 more
core +1 more source
Ligand-dependent modulation of MDM2 lid flexibility.
, 2015 Left) per-lid residue average backbone RMSD. Right) Backbone RMSD over full lid (green) or core (blue) regions. From top to bottom, A) apo MDM2, B) p53-bound MDM2, C) Nutlin-3a-bound MDM2, D) Bzd-bound MDM2, E) Pip2-bound MDM2.
Juan A. Bueren-Calabuig (749993) +1 more
core +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Dedifferentiated liposarcoma (DDLPS) is a rare soft tissue sarcoma with limited real‐world epidemiologic data. This nationwide retrospective study describes the epidemiology, management, and outcomes of DDLPS in France using the NETSARC+ national sarcoma registry.
Julien Bollard +23 more
wiley +1 more source
p53 causes rapid SHP protein degradation independent of Mdm2.
, 2013 A: Western blots to determine the effects of p53 and Mdm2 on SHP protein expression in p53−/−Mdm2−/− MEF cells lacking p53 and Mdm2. The p53−/−Mdm2−/− MEF cells were transfected with Flag-SHP, Flag-p53 or Mdm2 expression vectors, and Mdm2, p53 or SHP ...
Zhihong Yang (118036) +3 more
core +1 more source
Journal of Surgical Oncology, EarlyView.ABSTRACT Background Although MDM2 FISH test has been increasingly used to differentiate ALT and benign lipomatous tumours, its impact on clinical outcome remains underexplored. This study investigated whether routine MDM2 FISH testing on preoperative biopsy is associated with a reduction in the recurrence risk of ALT.
Samuel O. H. Ching +5 more
wiley +1 more source
BiomoleculesMouse double minute 2 (MDM2) is an oncoprotein that is frequently overexpressed in tumors and enhances cellular transformation. Owing to the important role of MDM2 in modulating p53 function, it is crucial to understand the mechanism underlying the ...
Satsuki Ryu +6 more
doaj +1 more source
Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma
The Laryngoscope, EarlyView.We investigated the mutational landscape and prognostic implications of recurrent/metastatic papillary thyroid carcinoma using nationwide C‐CAT data from 348 patients. CDKN2A, KMT2D, and concurrent TERT/BRAF mutations were independently associated with poorer overall survival, highlighting the potential prognostic value of comprehensive genomic ...
Hiromi Nagano +3 more
wiley +1 more source
Comparison of Mdm2-M62A:M06 and Mdm2:SAH-8 structures.
, 2014 A, The staple in both Mdm2:M06 complexes, found in the asymmetric unit, packs against residues L54, F55 and more closely with G58 (shown in red) in the absence of M62.
Robert Robinson (613870) +8 more
core +1 more source
Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer
Medicinal Research Reviews, EarlyView.ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek +3 more
wiley +1 more source
Senotherapeutics for Knee Osteoarthritis
Medicinal Research Reviews, EarlyView.ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman +6 more
wiley +1 more source