Results 101 to 110 of about 64,512 (289)
Advanced Intelligent Discovery, EarlyView.An ultra‐fast small‐sample AI consensus pipeline combines co‐folding and docking to target structure‐lacking p53 monomers. Its optimal mini‐protein binder shows robust interfacial affinity and promising druggability, supplying unprecedented antitumor p53 templates.
Ningyao Li +9 more
wiley +1 more source
, 2017 (A) Lysates from HEK-293T cells expressing Myc-NUB1 alone or together with Mdm2 were subjected to immunoprecipitation with an anti-Mdm2 antibody. Proteins were separated through SDS-PAGE and NUB1 was detected by western blotting using an anti-Myc ...
Juan-Lucio Iovanna (1815070) +5 more
core +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac +16 more
wiley +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
Bulletin of the Korean Chemical Society, EarlyView.Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon +3 more
wiley +1 more source
MDM2-C Functions as an E3 Ubiquitin Ligase
Cancer Management and Research, 2020 Jun Yeob Kim,1 Rusia Lee,1,2 Gu Xiao,1 Dominique Forbes,1 Jill Bargonetti1– 3 1The Department of Biological Sciences, Hunter College, City University of New York, New York, NY, USA; 2Biology PhD Program, The Graduate Center of Biology, City ...
Kim JY +4 more
doaj
, 2007 在許多癌症中均發現MDM2(mouse double minute 2)基因有過量表現之情形，這是因為MDM2基因可以抑制腫瘤抑制基因p53的表現量。除此以外，目前的研究也發現MDM2可以參與其他獨立於p53的功能，其在細胞週期調控、分化、細胞命運的決定、DNA的修補、基本轉錄調控及其他方面的功能上均扮演重要角色。此外，在不同的模式動物如轉殖鼠、果蠅跟斑馬魚之研究顯示過量表現MDM2會抑制生長及影響細胞分化。因此本實驗中我們利用肝臟發綠螢光的轉基因斑馬魚 ...
Huang, Shin-Jie, 黃信傑
core
TBP-1 is a downstream target of MDM2 activation.
, 2013 A: U2OS cells were either transfected (lanes +) or untransfected (lanes −) with the MDM2 expression plasmid. 24 hrs after transfection cell extract was prepared and subjected either to immunoprecipitation with anti-TBP-1 antibody where indicated or, with
Fabio Tolino (342851) +10 more
core +1 more source
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Cancer Management and Research, 2021 Juan Ye,1,2,* Lin Zhang,2– 4,* Zhongwen Li,1 Runduan Lin,3 Yiling Song,3 Huanhe Ni,2 Xiaoxia Gou,1 Rongzhang Xie4 1Department of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People’s ...
Ye J +7 more
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