Results 11 to 20 of about 64,512 (289)
The Functional Roles of the MDM2 Splice Variants P2-MDM2-10 and MDM2-∆5 in Breast Cancer Cells
Translational Oncology, 2017 BACKGROUND: MDM2 is a negative regulator of p53 and is upregulated in numerous human cancers. While different MDM2 splice variants have been observed in both normal tissues and malignant cells, their functions are poorly understood. METHODS: We evaluated
Johanna Huun +7 more
doaj +4 more sources
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control [PDF]
Proceedings of the National Academy of Sciences, 2001 The p53 tumor suppressor protein and the MDM2 oncoprotein form a feedback-control loop that up-regulates cellular MDM2 production, blocks p53 activity, and promotes p53 decay.
Cohen, Stanley N. +4 more
core +3 more sources
Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells [PDF]
BMC Cell Biology, 2017 Background The murine double minute 2 (MDM2) is an oncogene and a negative regulator of the tumor suppressor protein p53. MDM2 is known to be amplified in numerous human cancers, and upregulation of MDM2 is considered to be an alternative mechanism of ...
Johanna Huun +6 more
doaj +3 more sources
International Journal of Molecular SciencesAmeloblastoma is a rare tumor but represents the most common odontogenic neoplasm. It is localized in the jaws and, although it is a benign, slow-growing tumor, it has an aggressive local behavior and high recurrence rate.
Konstantinos I. Tosios +2 more
core +5 more sources
Current Pharmaceutical Design, 2012 The protein-protein interaction (PPI) between p53 and its negative regulator MDM2 comprises one of the most important and intensely studied PPI's involved in preventing the initiation of cancer.
Doemling, Alex, Khoury, Kareem
core +3 more sources
MDM2- an indispensable player in tumorigenesis [PDF]
, 2023 Murine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic potential. Since its identification, various cancer-promoting roles of MDM2 such as growth stimulation, sustained angiogenesis, metabolic reprogramming, apoptosis evasion ...
Zafar, Aasma +8 more
core +1 more source
Genes & Cancer, 2012 While the presence, in the invertebrates, of genes related in sequence and function to the vertebrate p53 family has been known since the discovery of the fly Drosophila melanogaster Dmp53 and the worm Caenorhabditis elegans cep-1 gene, the failure to discover homologs of the essential vertebrate negative regulator of p53 Mdm2 in these species led to ...
David P, Lane, Chandra, Verma
openaire +2 more sources
Aquaculture Reports, 2021 The proteins P53 and Mdm2 (murine double minute 2) play a prominent role in preventing the induction of uncontrolled apoptosis in numerous cell types. To better understand their potential roles during gonadal development in Monopterus albus, p53 and mdm2
Zhi He +11 more
doaj +1 more source
Solution-State Preorganization of Cyclic β-Hairpin Ligands Determines Binding Mechanism and Affinities for MDM2 [PDF]
, 2021 Understanding mechanisms of protein folding and binding is crucial to designing their molecular function. Molecular dynamics (MD) simulations and Markov State Model (MSM) approaches provide a powerful way to understand complex conformational change that ...
Mate, Erdelyi +3 more
core +3 more sources
The contribution of the acidic domain of MDM2 to p53 and MDM2 stability [PDF]
Oncogene, 2001 p53 and MDM2 are both degraded by the ubiquitin-proteasome pathway. MDM2 binds p53 and promotes its rapid degradation. MDM2 is an E3 ligase that activates self and p53 ubiquitylation. Moreover, MDM2 nuclear-cytoplasmic shuttling contributes to p53 degradation in the cytoplasm.
Argentini, Manuela +2 more
openaire +2 more sources