Results 11 to 20 of about 63,224 (282)
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control [PDF]
Proceedings of the National Academy of Sciences, 2001 The p53 tumor suppressor protein and the MDM2 oncoprotein form a feedback-control loop that up-regulates cellular MDM2 production, blocks p53 activity, and promotes p53 decay. tsg101 was discovered as a gene whose deficiency results in neoplastic transformation of NIH 3T3 cells and the ...
L, Li +4 more
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MDM2- an indispensable player in tumorigenesis [PDF]
, 2023 Murine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic potential. Since its identification, various cancer-promoting roles of MDM2 such as growth stimulation, sustained angiogenesis, metabolic reprogramming, apoptosis evasion ...
Zafar, Aasma +8 more
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Immunohistochemical Study of MDM2 Expression in Odontogenic Keratocyst and Dentigerous Cyst [PDF]
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2023 Introduction: Dentigerous cyst and odontogenic keratocyst (OKC) are two of the most common developmental odontogenic cysts. Different developmental mechanism and biological behavior of OKC is due to unknown factors inherent in the epithelium or enzymatic
Najmeh Jafari +2 more
doaj
Indian Journal of Pathology and Microbiology, 2022 Background: Liposarcomas including atypical lipomatous tumors (ALT)/well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPSs) display a histomorphological spectrum with their several diagnostic mimics.
Bharat Rekhi +4 more
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Analysis of dedifferentiated liposarcomas emphasizing the diagnostic dilemmas
Indian Journal of Medical and Paediatric Oncology, 2020 Introduction: Dedifferentiated liposarcoma (DDLPS) is defined as a progression of well-differentiated liposarcoma (WDLPS) to another nonlipogenic sarcoma. Since a variety of heterologous sarcomas can be encountered in dedifferentiation, clinical dilemmas
Bhagat Singh Lali +4 more
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Aquaculture Reports, 2021 The proteins P53 and Mdm2 (murine double minute 2) play a prominent role in preventing the induction of uncontrolled apoptosis in numerous cell types. To better understand their potential roles during gonadal development in Monopterus albus, p53 and mdm2
Zhi He +11 more
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The contribution of the acidic domain of MDM2 to p53 and MDM2 stability [PDF]
Oncogene, 2001 p53 and MDM2 are both degraded by the ubiquitin-proteasome pathway. MDM2 binds p53 and promotes its rapid degradation. MDM2 is an E3 ligase that activates self and p53 ubiquitylation. Moreover, MDM2 nuclear-cytoplasmic shuttling contributes to p53 degradation in the cytoplasm.
Argentini, Manuela +2 more
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The molecular dynamics of MDM2 [PDF]
Cell Cycle, 2010 The pro-oncogenic signals of a vast number of anti-cancer drug targets are mediated by protein-protein interactions. This has made such targets less attractive to classic drug discovery programmes. New paradigms in the protein science field have revealed, however, that many protein-protein complexes are stabilized by an interaction between an ...
Judith, Nicholson, Ted R, Hupp
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Cancer Science, 2020 AbstractThe Mdm2 oncoprotein and its association with p53 were discovered 30 years ago, and a cornucopia of activities and regulatory pathways have been associated with it. In this review, we will raise questions about Mdm2 and its cousin Mdm4 that we consider worth pursuing in future research, reaching from molecular structures and intracellular ...
Matthias Dobbelstein, Arnold J. Levine
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Allosteric regulation of MDM2 protein [PDF]
, 2010 The diverse functions of the MDM2 oncoprotein in growth control and tumourigenesis are managed through coordinated regulation of its discrete domains induced by both extrinsic and intrinsic stimuli.
Wawrzynów, Bartosz
core +3 more sources