Results 161 to 170 of about 64,512 (289)

Correction: Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2. [PDF]

PLoS One
Wiech M, Olszewski MB, Tracz-Gaszewska Z, Wawrzynow B, Zylicz M, Zylicz A.   +5 more
europepmc   +1 more source

High‐resolution spatial transcriptomic atlas of mouse soleus muscle: Unveiling single cell and subcellular heterogeneity in health and denervation

The FEBS Journal, EarlyView.
Seq‐Scope maps skeletal muscle transcriptomes at high spatial resolution while preserving histological context, revealing distinct responses of myofibers, neuromuscular junctions, and stromal cells to denervation. This spatial view uncovers fiber type‐specific and localized remodeling across intact muscle tissue.
Jer‐En Hsu, Lloyd Ruiz, Yongha Hwang, Steve D. Guzman, Chun‐Seok Cho, Weiqiu Cheng, Yichen Si, Peter Macpherson, Angelo Anacleto, Qingyang Zhao, Xiaoya Zhao, Mitchell Schrank, Goo Jun, Hyun Min Kang, Myungjin Kim, Susan V. Brooks, Jun Hee Lee   +16 more
wiley   +1 more source

Computational Analysis of the Homologous Mouse Double RINGs Interface for Targeted Anticancer Drug Design. [PDF]

Biomedicines
Adewumi AT, Sekele L, Oluyemi WM, Eze SC, Mosebi S.   +4 more
europepmc   +1 more source

Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening

, 2018
Noor Atatreh,1 Mohammad A Ghattas,1 Sanaa K Bardaweel,2 Sara Al Rawashdeh,1 Mohammad Al Sorkhy1 1Department of Pharmaceutical Sciences, College of Pharmacy, Al Ain University of Science and Technology, Al Ain, Abu Dhabi, United Arab Emirates ...
Atatreh N, Al Rawashdeh S, Al Sorkhy M, Bardaweel SK, Ghattas MA   +4 more
core  

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

Transient peak of p53 induction persists at low radiation doses in MCF-7 cells. [PDF]

Mol Biol Rep
Danilova I, Klementová J, Jarošová Š, Kundrát P, Zíková M, Davídková M.   +5 more
europepmc   +1 more source

PLAG1‐rearranged paediatric fibromyxoid tumour: clinicopathological, molecular and epigenetic analysis of 10 cases supporting a morphological spectrum with lipoblastoma

Histopathology, EarlyView.
P‐FMT histologically resembles fibroblastic lipoblastoma and has similar gene fusions, DNA methylation profiles, and benign clinical behaviour, supporting classification of P‐FMT as a morphological variant of lipoblastoma. Aim Paediatric PLAG1‐rearranged fibromyxoid tumour (P‐FMT) is an emerging soft‐tissue neoplasm characterized by predominantly ...
Faizan Malik, Selene C Koo, Quynh T Tran, Carina A Dehner, Robert E Ruiz, Meera Hameed, Anthony Arnoldo, Robert Siddaway, Brent A Orr, Rose Chami   +9 more
wiley   +1 more source

Mdm2 p53 binding protein homolog (MDM2) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Targeted Delivery and ROS-Responsive Release of Lutein Nanoassemblies Inhibit Myocardial Ischemia-Reperfusion Injury by Improving Mitochondrial Function

International Journal of Nanomedicine
Pilong Shi,1,* Yuetong Sha,1,* Xinran Wang,1,* Tao Yang,1 Jiawei Wu,1 Jiajun Zhou,1 Kai Liu,1 Xue Guan,2 Song Wang,1 Yongsheng Liu,1 Jingquan Gao,3 Hongli Sun,1 Tao Ban,1 Yonggang Cao1 1Department of Pharmacology, Harbin Medical University ...
Shi P, Sha Y, Wang X, Yang T, Wu J, Zhou J, Liu K, Guan X, Wang S, Liu Y, Gao J, Sun H, Ban T, Cao Y   +13 more
doaj