Results 171 to 180 of about 63,224 (282)

Droplet Digital PCR Assessment of <i>MDM2</i> Amplification in Liposarcoma Diagnosis and Prognosis: A French Single-Center Cohort Study. [PDF]

Int J Mol Sci
Amri A, Haffner A, Fina F, Appay R, Duffaud F, Salas S, Mattéi JC, Rochwerger A, Chagnaud C, Fernandez R, Paula AM, Just PA, Hamouda I, Diai S, Neda CA, Roll P, Kaspi E, Gallardo C, Barlier A, Bouvier C, Frankel D, Macagno N.   +21 more
europepmc   +1 more source

Single‐Cell Transcriptomic Identification of Drug‐Tolerant Persister Mechanisms in Capecitabine‐Treated Triple‐Negative Breast Cancer

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and HER2 expression. This lack of receptors limits targeted therapies and contributes to high rates of recurrence.
Md Naiyem Islam, Md Kaziul Islam Sarkar Suja, Alif Al Takbir, Md. Kaderi Kibria   +3 more
wiley   +1 more source

E3 Ubiquitin Ligase MDM2 Promotes Growth and CD8⁺ T Cell Dysfunction in Gastric Cancer Through Degradation of SST. [PDF]

J Gastroenterol Hepatol
Yang F, Zhang X, Ji J, Li S, Fang X, Yang L, Guo X.   +6 more
europepmc   +1 more source

E3 Ubiquitin Ligases in MASH‐Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities

Liver International, Volume 46, Issue 10, October 2026.
ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a major cause of progressive liver fibrosis and can ultimately lead to cirrhosis and hepatocellular carcinoma (HCC). MASH‐associated liver fibrosis develops through a complex interplay among lipotoxic hepatocyte injury, oxidative and endoplasmic reticulum stress, inflammatory ...
Ah‐Reum Oh, Yelin Jeong, Young Hoon Jung, Young Un Kim, HyunJoon Gi, Do‐Wan Kim, Young Du Choi, Sang Bae Lee, KyeongJin Kim   +8 more
wiley   +1 more source

Undifferentiated pleomorphic sarcoma of the small intestine presenting with intussusception in a patient with prior well-differentiated liposarcoma. [PDF]

J Surg Case Rep
Otsu S, Murao Y, Shiraki H, Tsutsumi A, Endo Y, Nakatsuka SI.   +5 more
europepmc   +1 more source

Proteome-wide target profiling of α-helix mimetics. [PDF]

RSC Chem Biol
Date A, Wall A, Kiely-Collins H, Flack T, Houghton JW, Lu J, Thomas AM, Zhang P, Wilson AJ, Tate EW, Barnard A.   +10 more
europepmc   +1 more source

MDM2 degraders for Merkel cell carcinoma: round peg in a round hole. [PDF]

J Clin Invest
Abdulkadir SA.
europepmc   +1 more source

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

Sclerosing Atypical Lipomatous Tumor with Myxomatous Features Presenting in the Plantar Heel: A Case Report. [PDF]

J Orthop Case Rep
Khan M, Ahmed S, Mustafa A, Asghar S, Hossain M.   +4 more
europepmc   +1 more source

Intra‐Abdominal Myxoid Leiomyosarcoma With PLAG1 Gene Rearrangement Following Prior Laparoscopic Myomectomy: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT PLAG1 immunohistochemistry and FISH were essential for diagnosis of extra‐uterine myxoid leiomyosarcoma and should be considered in myxoid intra‐abdominal tumors, especially in patients with previous uterine surgery.
Cheng‐En Hsieh, Po‐Hsuan Wu, Chang‐Wei Su, Yu‐Chun Ma, Hsuan‐Ying Huang   +4 more
wiley   +1 more source