Results 191 to 200 of about 64,512 (289)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, Volume 20, Issue 11, Page 2839-2859, November 2026.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

p53; MDM2 [PDF]

Science-Business eXchange, 2008
openaire   +3 more sources

MDM2 Alters Cellular Iron Homeostasis by Promoting the Degradation of Proteins Involved in Iron Storage and Iron Export. [PDF]

Curr Issues Mol Biol
Shi Y, Zhang J.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, Volume 20, Issue 11, Page 2718-2740, November 2026.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mdm2 p53 binding protein homolog (MDM2; HDM2) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Strain and cell type dependent induction of tunnelling nanotube-like projections by African swine fever virus. [PDF]

Vet Res
Droesbeke B, Balmelle N, Nauwynck HJ, Favoreel H, Tignon M.   +4 more
europepmc   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, Volume 38, Issue 61, 2 November 2026.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Primary extraskeletal osteosarcoma of the retroperitoneum: a case report. [PDF]

Front Med (Lausanne)
Ren X, Xie T, Li L, Jin X, Zhang M.
europepmc   +1 more source

Surgical Management of a Giant Oropharyngeal Angiolipoma Presenting With Severe Dysphagia: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Lipomas of the oropharynx are rare, accounting for less than 5% of benign oropharyngeal neoplasms. Most remain asymptomatic until they grow large enough to cause obstructive symptoms. Oropharyngeal angiolipomas are extremely rare and can present with life‐altering symptoms such as dysphagia.
Mujaheed Suleman, Kondo Chilonga, Alex Mremi, Evance Salvatory Rwomurushaka, Felister Uisso, David Msuya, Happiness Sway, Jay Lodhia   +7 more
wiley   +1 more source

Alternative Isoforms as Molecular Modulators of Cellular Senescence in Cancer. [PDF]

Cancers (Basel)
García-Heredia JM.
europepmc   +1 more source