Results 201 to 210 of about 63,224 (282)

MEIS1::NCOA2 Rearranged Spindle Cell Neoplasm of Vulva With Unusual Low-Grade Morphology. [PDF]

Genes Chromosomes Cancer
Soni P, Song L, Phung J, Colebatch A, Gross JM, Argani P, Dorwal P.   +6 more
europepmc   +1 more source

Anticancer and Cardioprotective Properties of Medicinal Mushrooms: Current Evidence and Future Prospects

New Zealand Journal of Botany, Volume 64, Issue 3, September 2026.
Introduction: Cardiotoxicity is an undesirable side effect of chemotherapy that limits the effectiveness of cancer treatment. Almost all cardiotoxic agents cause cardiovascular complications, leading to oxidative stress and other pathological conditions.
Susanna Badalyan, Sylvie Rapior, Anush Barkhudaryan   +2 more
wiley   +1 more source

Targeting Mouse Double Minute 2 Homolog (MDM2) Oncogene in Breast Adenocarcinoma. [PDF]

Maedica (Bucur)
Niotis A, Mastronikoli S, Spyropoulou D, Adamopoulou M, Fotiades P, Vylliotis A, Tsantoulas A, Tsiambas E.   +7 more
europepmc   +1 more source

Avoiding pitfalls when modelling ligands in macromolecular crystallography

Acta Crystallographica Section D, Volume 82, Issue 9, Page 1016-1029, September 2026.
Flawed protein–ligand X‐ray structures can misdirect drug discovery based on PDB‐deposited models. This review uses publicly available PDB examples to highlight potential pitfalls, from absent ligands to incorrect chemistry, and presents a practical validation approach to improve model reliability.The determination of protein–ligand complex structures ...
Oliver S. Smart, Andrew Sharff, Claus Flensburg, Clemens Vonrhein, Gérard Bricogne   +4 more
wiley   +1 more source

Spirooxindole Derivatives as Emerging Scaffolds in Drug Discovery: Synthetic Strategies, Structure-Activity Relationship, and Biological Activities. [PDF]

ChemMedChem
Kalita RC, Bezbaruah S, Patle D.
europepmc   +1 more source

MDM2 (SNP309) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

A Mechanism‐Based Framework for Anti‐Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell‐Based Interventions

Aging Cell, Volume 25, Issue 9, September 2026.
The aging of the human body is a complex process driven by multiple contributing factors. Based on their underlying mechanisms, current anti‐aging interventions can be classified into six primary categories. This paper summarizes the most promising anti‐aging strategies within each class. ABSTRACT The global prevalence of aging and age‐related diseases
Feifei Li, Yankai Wang, Gelin Wang, Jiguo Chen, Song Huang   +4 more
wiley   +1 more source

Retraction Note: Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells. [PDF]

Sci Rep
Daniele S, Costa B, Zappelli E, Da Pozzo E, Sestito S, Nesi G, Campiglia P, Marinelli L, Novellino E, Rapposelli S, Martini C.   +10 more
europepmc   +1 more source

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, Volume 117, Issue 9, Page 2567-2585, September 2026.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source

Pleomorphic Adenoma of the Palate with Bizarre Ductal and Myoepithelial Cells: A Case Image. [PDF]

Head Neck Pathol
Hirose K, Nakaguro M, Kawamura K, Mori T, Toyosawa S.   +4 more
europepmc   +1 more source