Results 201 to 210 of about 64,512 (289)

Plasma Lipidomic Features of Adolescent Major Depressive Disorder and Lipid Changes After Fluoxetine Treatment

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Dysregulated plasma lipid homeostasis with aberrant triglycerides, lysophospholipids, and membrane sphingolipids represents a core pathological feature of adolescent major depressive disorder. Eight‐week fluoxetine treatment remodels lipid profiles including bile acid metabolites and modulates key signaling pathways, supporting novel lipid‐based ...
Chenxi Liu, Yao Li, Hanchen Hou, Jiamei Guo, Bingjie Qin, Xiaoxia Xu, Yuqian He, Tingting Lei, Fei Chen, Lige Zhang, Quanbing Liu, Li Gao, Jiaqi Shi, Haoran Xing, Teng Teng, Tian Qiu, Xinyu Zhou   +16 more
wiley   +1 more source

Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source

[Retracted] CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells. [PDF]

Mol Med Rep
Cao LQ, Wang YN, Liang M, Pan MZ.
europepmc   +1 more source

Tree Shrew as an Emerging Model for Aging Research: Characterization of Senescence and Therapeutic Interventions

Aging Cell, Volume 25, Issue 11, November 2026.
Compared with mouse cells, tree shrew fibroblasts more faithfully recapitulate the hallmarks of human cellular senescence. In vivo, aged tree shrews exhibit transcriptomic signatures of aging across multiple organs that closely mirror those observed in humans.
Qiuni Luo, Wenxian Xiao, Xin Dong, Ayesha Nisar, Yuhua Ma, Xiang Lai, Raoxian Bai, Meiting Zi, Qi Geng, Qingyu Zhang, Cheng Zhang, Qiong Wang, Naheemat Modupeola Gold, Zhen Zhou, Li Hu, Ao Zhang, Qinghua Zeng, Jing Liu, Sawar Khan, Longbao Lv, Yonghan He   +20 more
wiley   +1 more source

Computational screening of natural product inhibitor stargeting the MDM2-p53 interaction: docking and molecular dynamics insights for retinoblastoma therapy. [PDF]

Am J Transl Res
Geng Y, Liu X, Kumar S, Geng Y.
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

A membrane-penetrating modified ascites-derived peptide, TAT-CPAP1, sensitizes TP53 wild-type ovarian cancer cells to platinum-based therapy through targeting the NOLC1-MDM2/MDM4 axis. [PDF]

Transl Oncol
Geng Z, Wang Z, Pan X, Xia C, Wang H, Wang X, Xu H, Xu J, Jia X.   +8 more
europepmc   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi, Mariko Akiba, Marin Yokomine, Masatake Sugita, Koji Umezawa, Yuto Hirota, Yutaka Akiyama, Jumpei Morimoto, Shinsuke Sando   +8 more
wiley   +2 more sources

Mirror-Peptidizer: In Silico Mirror-Image Screening Enables De Novo Design of D-Peptide Binders without D-Protein Synthesis. [PDF]

Research (Wash D C)
Ma B, Wang Z, Jian Y, Mi Y, Chen S, Hu H, Li X.   +6 more
europepmc   +1 more source