Results 211 to 220 of about 63,224 (282)

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, Volume 59, Issue 9, September 2026.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Low-grade osteogenic tumor with secondary aneurysmal bone cyst: Distinguishing osteoblastoma from low-grade osteosarcoma in the setting of noncanonical molecular findings. [PDF]

Radiol Case Rep
Shabbir-Hussain R, Malerba R, Aljohani R, Nani J, Hussain M, Proca D.   +5 more
europepmc   +1 more source

MDM2 Inhibitor [PDF]

, 2020
openaire   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Adult Granulosa Cell Tumor With Low-Level Amplifications of <i>JAK2</i>, <i>ERBB3</i>, <i>CDK4</i>, and <i>MDM2</i>: A Rare Testicular Tumor. [PDF]

Case Rep Urol
Moran C, Skibiel C, Shojaei H, Tomaszewski JJ, Edmonston TB, Barshay V, Birbe R.   +6 more
europepmc   +1 more source

Perineurioma‐like EMA‐positive calvarial neoplasms: clinicopathological study of eight cases

Histopathology, Volume 89, Issue 3, Page 544-553, September 2026.
Perineurioma‐like, EMA‐positive calvarial neoplasms (PLECN) are a rare group of intraosseous spindle cell tumours that demonstrate overlapping morphologic features of perineurioma and fibroblastic meningioma. These lesions tend to behave indolently but show a propensity for progressive growth.
Raheel Rizwan, Yingting Mok, Josephine K Dermawan, Alexandra Isaacson, Veronica Ulici, Scott E Kilpatrick, John D Reith, Gabrielle Yeaney, Hakan Ilaslan, Karen J Fritchie   +9 more
wiley   +1 more source

FBXO5 regulates RPL23A to promote MDM2-mediated p53 degradation and facilitate malignant progression of breast cancer. [PDF]

Breast Cancer Res
Wang J, Yao L, Chen Y, Zhu Q, Xu W, Xu A, Li X, Chen Z, Cheng M, Leng Q, Li C, Deng X, Fu D.   +12 more
europepmc   +1 more source

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

Histopathology, Volume 89, Issue 3, Page 442-455, September 2026.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello, Valentina Angerilli, Mario Domenico Rizzato, Edoardo Maffii, Carlotta Ceccon, Matilde Callegarin, Marianna Sabbadin, Monia Niero, Luisa Toffolatti, Francesca Bergamo, Paola Parente, Luca Mastracci, Federica Grillo, Alessandro Vanoli, Paola Mattiolo, Claudio Luchini, Angelo Paolo Dei Tos, Umberto Cillo, Giacomo Zanus, Sara Lonardi, Matteo Fassan   +20 more
wiley   +1 more source

USP21 functions as an oncogenic regulator of the Mdm2-p53 axis in colorectal cancer. [PDF]

Cell Death Discov
Wang Z, Yao B, He W, Guo X, Yu N, Tang S, Luo L, Wang F, Zhao K, Mei Y.   +9 more
europepmc   +1 more source

Integrating Molecular Classification Based on FGFR3, KRAS, HRAS, and TP53 Mutation With TNM Staging Modestly Improves Prediction of Prognosis of Upper Tract Urothelial Carcinoma After Surgery

International Journal of Urology, Volume 33, Issue 9, September 2026.
ABSTRACT Purpose To evaluate whether a simplified mutation‐based classification using archival formalin‐fixed paraffin‐embedded (FFPE) specimens provides prognostic information beyond pathological stage in patients with upper tract urothelial carcinoma (UTUC) undergoing nephroureterectomy.
Kazuki Yanagida, Ichiro Takada, Tsuyoshi Ishida, Kazuki Takei, Kenjiro Kishitani, Hideyuki Minagawa, Taketo Kawai, Tomoyuki Kaneko, Yuko Sasajima, Tohru Nakagawa   +9 more
wiley   +1 more source