Results 231 to 240 of about 63,224 (282)

The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication. [PDF]

Elife
Ming SL, Du MH, Yang JM, Guo YD, Pan JJ, Lu WF, Wang J, Zeng L, Chu BB.   +8 more
europepmc   +1 more source

Lnc00892 enhances cisplatin sensitivity by inducing apoptosis through the BTAF1/MDM2/STAT5B/XIAP axis in bladder cancer cells. [PDF]

Biol Direct
Chang Y, Sun N, Liu Y, Jin Z, Zhang P, Wang S, Chen J, Liu J, Lin Z, Lu Y, Huang H, Huang C, Jin H.   +12 more
europepmc   +1 more source

Beyond the Ribosome: The Expanding Role of the Nucleolus in Neurodegenerative Pathways. [PDF]

Mol Neurobiol
Iacono D, Feltis GC.
europepmc   +1 more source

Correction: SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle. [PDF]

Oncogene
Lu YF, Xu XP, Lu XP, Zhu Q, Liu G, Bao YT, Wen H, Li YL, Gu W, Zhu WG.   +9 more
europepmc   +1 more source

A case of retroperitoneal dedifferentiated liposarcoma. [PDF]

Radiol Case Rep
Lyu Y, Zhou Y.
europepmc   +1 more source

Clinicopathological Analysis of Lipomatous Tumors in a Tertiary Care Center. [PDF]

Cureus
Maheshwari D, D'Cruze L, R B, Balasubramanian S.   +3 more
europepmc   +1 more source

P53 Mdm2 Inhibitors

Current Pharmaceutical Design, 2012
The protein-protein interaction (PPI) between p53 and its negative regulator MDM2 comprises one of the most important and intensely studied PPI's involved in preventing the initiation of cancer. The interaction between p53 and MDM2 is conformation-based and is tightly regulated on multiple levels. Due to the Angstrom level structural insight there is a
Kareem, Khoury, Alex, Dömling
core   +4 more sources

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Binding of an inhibitor of the p53/MDM2 Interaction to MDM2

Chemical Communications, 2003
The mode of action of the secondary metabolite chlorofusin, which antagonises the interaction between p53 and MDM2, involves direct binding to the N-terminal domain of MDM2.
Duncan, Sara J., Cooper, Matthew A., Williams, Dudley H.   +2 more
openaire   +5 more sources

MDM2 and Prognosis

Molecular Cancer Research, 2004
Abstract The cellular stress response pathway regulated by the p53 tumor suppressor is critical to the maintenance of genomic integrity and to the prevention of oncogenic transformation. Intracellular levels of p53 are tightly regulated by an autoregulatory feedback loop comprised of p53 and MDM2. It might be predicted that disruption of
Kenan, Onel, Carlos, Cordon-Cardo
openaire   +2 more sources