Results 251 to 260 of about 63,224 (282)
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2002
One of the major defense mechanisms against the development of cancer is governed by the tumor-suppressor protein p53. The p53 protein can induce growth arrest and apoptosis, and, owing to these important functions in controlling cell proliferation, p53 itself has to be tightly regulated.
Andrea Klotzbücher +1 more
openaire +1 more source
One of the major defense mechanisms against the development of cancer is governed by the tumor-suppressor protein p53. The p53 protein can induce growth arrest and apoptosis, and, owing to these important functions in controlling cell proliferation, p53 itself has to be tightly regulated.
Andrea Klotzbücher +1 more
openaire +1 more source
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1998
G, Lozano, R, Montes de Oca Luna
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G, Lozano, R, Montes de Oca Luna
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Molecular cancer research : MCR, 2004
The murine double minute 2 (mdm2) gene encodes a negative regulator of the p53 tumor suppressor. Amplification of mdm2 or increased expression by unknown mechanisms occurs in many tumors. Thus, increased levels of MDM2 would inactivate the apoptotic and cell cycle arrest functions of p53, as do deletion or mutation of p53, common events in the genesis ...
Tomoo, Iwakuma, Guillermina, Lozano
openaire +1 more source
The murine double minute 2 (mdm2) gene encodes a negative regulator of the p53 tumor suppressor. Amplification of mdm2 or increased expression by unknown mechanisms occurs in many tumors. Thus, increased levels of MDM2 would inactivate the apoptotic and cell cycle arrest functions of p53, as do deletion or mutation of p53, common events in the genesis ...
Tomoo, Iwakuma, Guillermina, Lozano
openaire +1 more source
Small-molecule MDM2 inhibitors in clinical trials for cancer therapy
European Journal of Medicinal Chemistry, 2022Fen-Er Chen
exaly
2020
Interaction between p53 and the E3 ubiquitin ligase murine double minute 2 homolog (MDM2) is regarded as an important target for anticancer therapeutics. The p53/MDM2 protein-protein interaction is one of the best-studied and most targeted intracellular processes related to cancer progression.
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Interaction between p53 and the E3 ubiquitin ligase murine double minute 2 homolog (MDM2) is regarded as an important target for anticancer therapeutics. The p53/MDM2 protein-protein interaction is one of the best-studied and most targeted intracellular processes related to cancer progression.
openaire +1 more source
Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas
Cancer Cell, 2017Debanjan Dhar +2 more
exaly
Targeting MDM2 for novel molecular therapy: Beyond oncology
Medicinal Research Reviews, 2020Jiangjiang Qin
exaly