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Trends in Genetics, 2001 The MDM2 protein suppresses the ability of p53 to inhibit cellular proliferation or to induce cell death. This property underlies the oncogenic potential of MDM2, which is overexpressed in various human tumours.
Sylvain Daujat +2 more
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Functions of the MDM2 oncoprotein
Cellular and Molecular Life Sciences CMLS, 1999The p53 protein is activated in response to physiological stress resulting in either a G1 arrest of cells or apoptosis. As such, p53 must be tightly regulated, and the MDM2 oncoprotein plays a central role in that regulatory process. The transcription of the Mdm2 oncogene is induced by the p53 protein after DNA damage, and the MDM2 protein then binds ...
D A, Freedman, L, Wu, A J, Levine
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Breast Cancer, 1997
The MDM2 protein, an oncogene product, is known to act by suppressing p53 function. Although gene amplification of MDM2 was frequently detected in human sarcomas, it was uncommon in the majority of epithelial tumors including breast cancer. However, recent reports have demonstrated that its translational activity is enhanced in a variety of carcinomas.
, Toi +4 more
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The MDM2 protein, an oncogene product, is known to act by suppressing p53 function. Although gene amplification of MDM2 was frequently detected in human sarcomas, it was uncommon in the majority of epithelial tumors including breast cancer. However, recent reports have demonstrated that its translational activity is enhanced in a variety of carcinomas.
, Toi +4 more
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Leukemia & Lymphoma, 1997
The mouse double minute 2 (mdm2) proto-oncogene was originally discovered as one of three genes that was amplified in a tumorigenic cell line derived from non-transformed Balb/c cells. Consistent with the expression pattern of mdm2 in these cells, it was later shown that the transforming potential of the mdm2 proto-oncogene can be activated by ...
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The mouse double minute 2 (mdm2) proto-oncogene was originally discovered as one of three genes that was amplified in a tumorigenic cell line derived from non-transformed Balb/c cells. Consistent with the expression pattern of mdm2 in these cells, it was later shown that the transforming potential of the mdm2 proto-oncogene can be activated by ...
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mdm2 gene alterations and mdm2 protein expression in breast carcinomas
The Journal of Pathology, 1995AbstractThis study investigates the mdm2 gene status and expression in 66 surgically resected human breast carcinomas, with correlations with clinico‐pathological and biological data (histological type, grading, steroid receptor status, p53 expression, proliferative activity). Four (7.7 per cent) out of 52 informative cases bear mdm2 gene amplification
MARCHETTI, Antonio +8 more
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Mdm2 in the Response to Radiation
Molecular Cancer Research, 2004Abstract Murine double minute 2 (Mdm2) is a critical component of the responses to both ionizing and UV radiation. The level of Mdm2 expression determines the extent to which radiation induces an increase in the activity of the p53 tumor suppressor.
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Cocompartmentalization of p53 and Mdm2 Is a Major Determinant for Mdm2-Mediated Degradation of p53
Experimental Cell Research, 2001The product of the Mdm2 oncogene directly interacts with p53 and promotes its ubiquitination and proteasomal degradation. Initial biological studies identified nuclear export sequences (NES), similar to that of the Rev protein from the human immunodeficiency virus, both in Mdm2 and p53.
Xirodimas, Dimitris +2 more
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2002
One of the major defense mechanisms against the development of cancer is governed by the tumor-suppressor protein p53. The p53 protein can induce growth arrest and apoptosis, and, owing to these important functions in controlling cell proliferation, p53 itself has to be tightly regulated.
Andrea Klotzbücher +1 more
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One of the major defense mechanisms against the development of cancer is governed by the tumor-suppressor protein p53. The p53 protein can induce growth arrest and apoptosis, and, owing to these important functions in controlling cell proliferation, p53 itself has to be tightly regulated.
Andrea Klotzbücher +1 more
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Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1998
G, Lozano, R, Montes de Oca Luna
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G, Lozano, R, Montes de Oca Luna
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Molecular cancer research : MCR, 2004
The murine double minute 2 (mdm2) gene encodes a negative regulator of the p53 tumor suppressor. Amplification of mdm2 or increased expression by unknown mechanisms occurs in many tumors. Thus, increased levels of MDM2 would inactivate the apoptotic and cell cycle arrest functions of p53, as do deletion or mutation of p53, common events in the genesis ...
Tomoo, Iwakuma, Guillermina, Lozano
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The murine double minute 2 (mdm2) gene encodes a negative regulator of the p53 tumor suppressor. Amplification of mdm2 or increased expression by unknown mechanisms occurs in many tumors. Thus, increased levels of MDM2 would inactivate the apoptotic and cell cycle arrest functions of p53, as do deletion or mutation of p53, common events in the genesis ...
Tomoo, Iwakuma, Guillermina, Lozano
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