Results 241 to 250 of about 64,512 (289)
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Binding of an inhibitor of the p53/MDM2 Interaction to MDM2
Chemical Communications, 2003The mode of action of the secondary metabolite chlorofusin, which antagonises the interaction between p53 and MDM2, involves direct binding to the N-terminal domain of MDM2.
Duncan, Sara J. +2 more
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Molecular Cancer Research, 2004
Abstract The cellular stress response pathway regulated by the p53 tumor suppressor is critical to the maintenance of genomic integrity and to the prevention of oncogenic transformation. Intracellular levels of p53 are tightly regulated by an autoregulatory feedback loop comprised of p53 and MDM2. It might be predicted that disruption of
Kenan, Onel, Carlos, Cordon-Cardo
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Abstract The cellular stress response pathway regulated by the p53 tumor suppressor is critical to the maintenance of genomic integrity and to the prevention of oncogenic transformation. Intracellular levels of p53 are tightly regulated by an autoregulatory feedback loop comprised of p53 and MDM2. It might be predicted that disruption of
Kenan, Onel, Carlos, Cordon-Cardo
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Association of p19ARF With Mdm2 Inhibits Ubiquitin Ligase Activity of Mdm2 for Tumor Suppressor p53
EMBO Journal, 1999 We have demonstrated previously that the oncoprotein Mdm2 has a ubiquitin ligase activity for the tumor suppressor p53 protein. In the present study, we charac-terize this ubiquitin ligase activity of Mdm2.
Hideyo Yasuda, R Honda
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Intrasteric regulation of MDM2
Trends in Biochemical Sciences, 2003Abstract The oncoprotein murine double minute 2 (MDM2) binds to the tumour suppressor protein p53 and negatively regulates growth suppression by catalyzing the ubiquitination and degradation of p53. Antagonizing MDM2 is an ataxia telangiectasia mutated (ATM) kinase- and checkpoint kinase-2 (CHK2)-dependent DNA-damage-inducible pathway that ...
Harumi, Shimizu, Ted R, Hupp
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MDM2-PROTAC versus MDM2 Inhibitors: Beyond p53 Reactivation
Cancer Discovery, 2023Summary: In this issue of Cancer Discovery, Adams and colleagues present the discovery of a potent PROTAC, MDM2 degrader, which activates wild-type p53 leading to cancer cell death. Importantly, in a number of in vitro and in vivo experiments, the authors show that the depletion of MDM2 by PROTAC kills p53 ...
Sylvain Peuget, Galina Selivanova
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