Results 241 to 250 of about 63,224 (282)

The MDM2 RING Domain and Central Acidic Domain Play Distinct Roles in MDM2 Protein Homodimerization and MDM2-MDMX Protein Heterodimerization [PDF]

Journal of Biological Chemistry, 2015
The oncoprotein murine double minute 2 (MDM2) is an E3 ligase that plays a prominent role in p53 suppression by promoting its polyubiquitination and proteasomal degradation.
Hengming Ke, Yan Ping Zhang
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Intrasteric regulation of MDM2

Trends in Biochemical Sciences, 2003
Abstract The oncoprotein murine double minute 2 (MDM2) binds to the tumour suppressor protein p53 and negatively regulates growth suppression by catalyzing the ubiquitination and degradation of p53. Antagonizing MDM2 is an ataxia telangiectasia mutated (ATM) kinase- and checkpoint kinase-2 (CHK2)-dependent DNA-damage-inducible pathway that ...
Harumi, Shimizu, Ted R, Hupp
openaire   +2 more sources

MDM2-PROTAC versus MDM2 Inhibitors: Beyond p53 Reactivation

Cancer Discovery, 2023
Summary: In this issue of Cancer Discovery, Adams and colleagues present the discovery of a potent PROTAC, MDM2 degrader, which activates wild-type p53 leading to cancer cell death. Importantly, in a number of in vitro and in vivo experiments, the authors show that the depletion of MDM2 by PROTAC kills p53 ...
Sylvain Peuget, Galina Selivanova
openaire   +2 more sources

MDM2: life without p53

Trends in Genetics, 2001
The MDM2 protein suppresses the ability of p53 to inhibit cellular proliferation or to induce cell death. This property underlies the oncogenic potential of MDM2, which is overexpressed in various human tumours.
Sylvain Daujat, J Piëtte
exaly   +2 more sources

Functions of the MDM2 oncoprotein

Cellular and Molecular Life Sciences CMLS, 1999
The p53 protein is activated in response to physiological stress resulting in either a G1 arrest of cells or apoptosis. As such, p53 must be tightly regulated, and the MDM2 oncoprotein plays a central role in that regulatory process. The transcription of the Mdm2 oncogene is induced by the p53 protein after DNA damage, and the MDM2 protein then binds ...
D A, Freedman, L, Wu, A J, Levine
openaire   +2 more sources

MDM2 in breast cancer

Breast Cancer, 1997
The MDM2 protein, an oncogene product, is known to act by suppressing p53 function. Although gene amplification of MDM2 was frequently detected in human sarcomas, it was uncommon in the majority of epithelial tumors including breast cancer. However, recent reports have demonstrated that its translational activity is enhanced in a variety of carcinomas.
, Toi, , Saji, , Suzuki, , Yamamoto, , Tominaga   +4 more
openaire   +2 more sources

The mdm2 Proto-Oncogene

Leukemia & Lymphoma, 1997
The mouse double minute 2 (mdm2) proto-oncogene was originally discovered as one of three genes that was amplified in a tumorigenic cell line derived from non-transformed Balb/c cells. Consistent with the expression pattern of mdm2 in these cells, it was later shown that the transforming potential of the mdm2 proto-oncogene can be activated by ...
openaire   +2 more sources

mdm2 gene alterations and mdm2 protein expression in breast carcinomas

The Journal of Pathology, 1995
AbstractThis study investigates the mdm2 gene status and expression in 66 surgically resected human breast carcinomas, with correlations with clinico‐pathological and biological data (histological type, grading, steroid receptor status, p53 expression, proliferative activity). Four (7.7 per cent) out of 52 informative cases bear mdm2 gene amplification
MARCHETTI, Antonio, BUTTITTA, Fiamma, Girlando S, Dalla Palma P, Pellegrini S, Fina P, Doglioni C, Bevilacqua G, Barbareschi M.   +8 more
openaire   +3 more sources

Mdm2 in the Response to Radiation

Molecular Cancer Research, 2004
Abstract Murine double minute 2 (Mdm2) is a critical component of the responses to both ionizing and UV radiation. The level of Mdm2 expression determines the extent to which radiation induces an increase in the activity of the p53 tumor suppressor.
openaire   +2 more sources

Cocompartmentalization of p53 and Mdm2 Is a Major Determinant for Mdm2-Mediated Degradation of p53

Experimental Cell Research, 2001
The product of the Mdm2 oncogene directly interacts with p53 and promotes its ubiquitination and proteasomal degradation. Initial biological studies identified nuclear export sequences (NES), similar to that of the Rev protein from the human immunodeficiency virus, both in Mdm2 and p53.
Xirodimas, Dimitris, Stephen, Charles W., Lane, David   +2 more
openaire   +3 more sources