Results 261 to 270 of about 64,512 (289)

MDM2

2014
openaire   +2 more sources

Small-Molecule MDM2 Inhibitors in Clinical Trials for Cancer Therapy

European Journal of Medicinal Chemistry, 2022
Fen-Er Chen
exaly  

Mdm2 Phosphorylation by Akt Regulates the p53 Response to Oxidative Stress to Promote Cell Proliferation and Tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America, 2021
Baktiar Karim, Loretah Chibaya, Stephen N Jones   +2 more
exaly  

?????????????????????????????????? "??????????????????? ?????????????? ??? ???????????????????? p53/MDM2 ??????????????????

2020
Interaction between p53 and the E3 ubiquitin ligase murine double minute 2 homolog (MDM2) is regarded as an important target for anticancer therapeutics. The p53/MDM2 protein-protein interaction is one of the best-studied and most targeted intracellular processes related to cancer progression.
openaire   +1 more source

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas

Cancer Cell, 2017
Debanjan Dhar, Laura Antonucci, Johan B Fagman   +2 more
exaly  

BAI1 Suppresses Medulloblastoma Formation by Protecting p53 From Mdm2-Mediated Degradation

Cancer Cell, 2018
George Gillespie, Shingo Takano, Hanwen Zhang   +2 more
exaly  

Structure of the MDM2/MDMX RING Domain Heterodimer Reveals Dimerization Is Required for Their Ubiquitylation in Trans

Cell Death and Differentiation, 2008
Clyde A Smith, John Silke, Peter D. Mace
exaly  

The Deubiquitinating Enzyme USP2a Regulates the p53 Pathway by Targeting Mdm2

EMBO Journal, 2007
Dimitris P Xirodimas, David P. Lane, Alison Sparks   +2 more
exaly  

Mdm2: Keeping p53 Under Control

Oncogene, 1997
Vincent Maréchal, J Piëtte, Jacques Piëtte   +2 more
exaly  

Mdm2 Haplo‐Insufficiency Profoundly Inhibits Myc‐Induced Lymphomagenesis

EMBO Journal, 2003
John L Cleveland, Christine M Eischen
exaly