Results 181 to 190 of about 18,018 (235)

MDMA (Ecstasy)

Annals of Clinical Psychiatry, 2007
3,4-Methylenedioxymethamphetamine (MDMA or Ecstasy) is a synthetic amphetamine analogue that is recreationally used to obtain a psychological effect of enhanced affiliative emotional response. Its use in Western countries appears to be increasing, particularly among young individuals.Pertinent basic and clinical literature is critically reviewed.A ...
Rif S, El-Mallakh, Henry David, Abraham
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Neurotoxicity of MDMA: Main effects and mechanisms [PDF]

Experimental Neurology, 2022
Preclinical and clinical studies indicate that 3,4-methylenedioxymethamphetamine (MDMA; ‘ecstasy’), in addition to having abuse potential, may elicit acute and persistent abnormalities of varying severity at the central level.
Giulia Costa, Krystyna Gołembiowska
exaly   +2 more sources

Dosing Psychedelics and MDMA

2021
Classic psychedelics, including psilocybin, lysergic acid diethylamide (LSD), dimethyltryptamine, and mescaline, and entactogens/empathogens, especially 3,4-methylenedioxymethamphetamine, have received renewed attention in psychiatric research and may be developed into medications for such indications as anxiety, depression, cluster headache, and ...
Liechti, Matthias E., Holze, Friederike
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The subjective effects of MDMA and mCPP in moderate MDMA users

Drug and Alcohol Dependence, 2001
The present study is part of a research program designed to better understand the neurochemical mechanisms underlying the abuse liability of 3,4-methylenedioxymethamphetamine (MDMA) in humans. In these studies, MDMA will be compared to prototypical dopamine (D-amphetamine) and serotonin (meta-chlorophenylpiperazine, mCPP) releasing agents on a variety ...
M E, Tancer, C E, Johanson
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MDMA

Abstract MDMA (3,4-methylenedioxymethamphetamine), although not considered to be a “classic” psychedelic, has been of particular interest for some time now as an agent for use in psychedelic-assisted therapy. Much of the research in recent years has focused on its potential applications in managing post-traumatic stress disorder ...
Elisha Waldman, Monica Romanko, Mark Skellie, Mark Bates   +3 more
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Pharmacology of MDMA in Humans

Annals of the New York Academy of Sciences, 2000
AbstractMDMA given at recreational doses (range tested 50 to 150 mg) to healthy volunteers, produced mydriasis and marked increases in systolic and diastolic blood pressure, heart rate, and pupillary diameter. MDMA induced changes on oral temperature. The time course of this observation was biphasic, as a slight decrease at 1 h and a slight increase at
, de la Torre R, M, Farré, P N, Roset, C H, Lopez, M, Mas, J, Ortuño, E, Menoyo, N, Pizarro, J, Segura, J, Cami   +9 more
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Immunomodulating Activity of MDMA

Annals of the New York Academy of Sciences, 2000
AbstractMDMA (3,4‐methylenedioxymethamphetamine) use can cause neurochemical, behavioral and endocrine alterations, similar to those produced by exposure to acute stress, suggesting its potential as a “chemical stressor.” It is known that stressful stimuli can produce a depression of immune function and an alteration in immune cells distribution.In ...
R, Pacifici, P, Zuccaro, M, Farré, S, Pichini, S, Di Carlo, P N, Roset, C H, Lopez, J, Ortuño, J, Segura, J, Camí, R, de la Torre   +10 more
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Increased responsiveness to MDMA in adult rats treated neonatally with MDMA

Neurotoxicology and Teratology, 2006
MDMA [(+/-)3,4-methylenedioxymethamphetamine, also known as ecstasy] is a popular recreational drug among women of reproductive age. The objective of this study was to investigate the long-term neurobehavioral consequences of early developmental MDMA exposure. On postnatal days (PD) 1-4, Sprague-Dawley rats received two 10 mg/kg injections of MDMA with
Brian J, Piper, Jerrold S, Meyer
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Methylenedioxymethamphetamine (MDMA, “Ecstasy”)

Pediatric Emergency Care, 2000
Ecstasy (MDMA) is an amphetamine derivative of growing popularity. The drug produces a range of toxicities when taken either in standard doses or overdose. In overdose it has major toxicity, producing several different life-threatening manifestations. Hepatotoxicity and hyponatremia are common but poorly understood consequences of MDMA overdose.
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(±)-MDMA and its enantiomers: potential therapeutic advantages of R(−)-MDMA

Psychopharmacology, 2017
The use of (±)-3,4-methylenedioxymethamphetamine ((±)-MDMA) as an adjunct to psychotherapy in the treatment of psychiatric and behavioral disorders dates back over 50 years. Only in recent years have controlled and peer-reviewed preclinical and clinical studies lent support to (±)-MDMA's hypothesized clinical utility. However, the clinical utility of (±
Elizabeth G, Pitts, Daniel W, Curry, Karly N, Hampshire, Matthew B, Young, Leonard L, Howell   +4 more
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