Results 71 to 80 of about 260,112 (235)

Do we need to detect isoniazid resistance in addition to rifampicin resistance in diagnostic tests for tuberculosis? [PDF]

PLoS ONE, 2014
Multidrug-resistant tuberculosis (MDR-TB) is resistant to both rifampicin (RIF) and isoniazid (INH). Whereas many TB diagnostics detect RIF-resistance, few detect INH-monoresistance, which is common and may increase risk of acquired MDR-TB.
Claudia M Denkinger, Madhukar Pai, David W Dowdy   +2 more
doaj   +1 more source

Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management

MedComm, Volume 7, Issue 10, October 2026.
A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley   +1 more source

Relationship Five Behavioral Indicators and Healthy Living with Tuberculosis Multidrug-Resistant

Jurnal Berkala Epidemiologi, 2014
Clean and healthy life style is a behavior that is closely related to the emergence of infectious diseases, including TB continued into MDR-TB. This study aimed to determine the relationship between the 5 behavioral indicators of clean and healthy living
Heri Mulyanto
doaj   +1 more source

Clinical Outcomes of a Digital Companion in Periodontal Care: A Randomised Controlled Trial

Journal of Clinical Periodontology, Volume 53, Issue 10, Page 1596-1609, October 2026.
ABSTRACT Aim To evaluate the efficacy of a digital health companion app as an adjunct to systematic periodontal therapy. Methods Seven German university dental centres conducted this multi‐centre randomised controlled trial. Adults with periodontitis (n = 194) were assigned to standard periodontal care with or without the Paro‐ComPas app.
Bettina Dannewitz, James Deschner, Christof Dörfer, Henrik Dommisch, Peter Eickholz, Lukas Förster, Lukasz Jablonowski, Neelam Lingwal, Stefan Listl, Maurice Rütters, Lina Weinert, Nihad El Sayed, the Paro‐ComPas Collaborators, Philipp Bani, Valentin Bartha, Thomas Beikler, Pablo Cores Ziskoven, Miriam Cyris, Ivana Elez, Maurice Fahn, Jens Göbel, Jana Gortschakow, Christian Graetz, Ahmad Haseeb, Oliver Heinze, Laurenz Hermans, Daniela Hoedke, Maren Kahl, Ti‐Sun Kim, Julian Kohlmüller, Denica Kuzmanova, Yola Meisel, Tugay Nebilir, Antares Outatzis, Gerd Schneider, Mario Schröder, Alexander Spies, Ingvi Spies, Claudia Springer, Leonie Staffeldt, Jessica Vasseur, Patrizia Winkler   +41 more
wiley   +1 more source

MDR-TB diagnosis and treatment under GFPMDT project in China during October 2006 to December 2013.

, 2019
GFPMDT-Global Fund Programmatic Management of drug resistant tuberculosis;MDR-TB: Multi drug-resistant tuberculosis.
Hemant Deepak Shewade (760494), Kathiresan Jeyashree (4096504), Renzhong Li (538735), Lixia Wang (331745), Yunzhou Ruan (4096507), Caihong Xu (1780648), Canyou Zhang (4096510), Hui Zhang (7197)   +7 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, Volume 38, Issue 51, 11 September 2026.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Half of rifampicin-resistant Mycobacterium tuberculosis complex isolated from tuberculosis patients in Sub-Saharan Africa have concomitant resistance to pyrazinamide.

, 2017
BackgroundBesides inclusion in 1st line regimens against tuberculosis (TB), pyrazinamide (PZA) is used in 2nd line anti-TB regimens, including in the short regimen for multidrug-resistant TB (MDR-TB) patients.
“Union short MDR-TB regimen study group”, Bouke Catherine de Jong, Kadanga, Abalo Essosimna, Ngabonziza, Jean Claude Semuto, Affolabi, Dissou, Sabine Houeto, Togo, Antieme Combo George, Ba, Fatoumata, Arnaud Trebucq, Abalo Essosimna Kadanga, Diarra, Bassirou, Elisa Tagliani, Riccardo Alagna, Thiam, Aliou, Willem Bram de Rijk, Aliou Thiam, Daneau, Geraldine, Diallo, Awa Ba, Géraldine Daneau, Houeto, Sabine, Rigouts, Leen, Anoumou Yaotsè Dagnra, Dissou Affolabi, de Rijk, Willem Bram, Jean Claude Semuto Ngabonziza, Fatoumata Ba, Ivan, Emil, Antieme Combo George Togo, Alagna, Riccardo, Valérie Schwoebel, Dagnra, Anoumou Yaotse, Awa Ba Diallo, null null, Tagliani, Elisa, Bassirou Diarra, Trebucq, Arnaud, Schwoebel, Valerie, de Jong, Bouke Catherine, Leen Rigouts, Emil Ivan   +39 more
core   +1 more source

AI‐Assisted SERS in Bacterial Diagnosis and Antimicrobial Susceptibility Testing: Advances, Gaps, and Translational Pathways

Advanced Sensor Research, Volume 5, Issue 9, September 2026.
This review examines recent advances in integrating artificial intelligence (AI) with surface‐enhanced Raman spectroscopy (SERS) for the detection of pathogenic bacteria and evaluation of drug resistance phenotypes. Key challenges in clinical translation are critically discussed, along with prospective solutions and future research directions ...
Chen Liu, Yu Liu, Junlu Wang, Yujie Liu, Qijia Zhan, Jiangang Liu, Ruoping Chen, Kun Zhang   +7 more
wiley   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

MT‐RNR1 genotype testing for preventing aminoglycoside‐mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3002-3011, September 2026.
Aminoglycosides are broad‐spectrum antibiotics used in the management of severe infections. Aminoglycosides are associated with nephrotoxicity and ototoxicity. Although dosing strategies such as once‐daily administration and therapeutic drug monitoring have reduced the incidence of nephrotoxicity, ototoxicity remains unpredictable and may occur at ...
John H. McDermott, Sian Hilton, Cinzia Dello Russo, Nicola Booth, Simon Drysdale, Philip Howard, Stephen Hughes, Mallinath Chakraborty, Helen McDevitt, Charlotte Alston, Maya Desai, Mike Beadsworth, Adam Reynolds, Serim Min, Katherine Payne, Munir Pirmohamed, William G. Newman   +16 more
wiley   +1 more source