Results 31 to 40 of about 24,597 (236)

Transcriptome-wide N6-methyladenosine modification profiling of long non-coding RNAs during replication of Marek’s disease virus in vitro

BMC Genomics, 2021
Background The newly discovered reversible N6-methyladenosine (m6A) modification plays an important regulatory role in gene expression. Long non-coding RNAs (lncRNAs) participate in Marek’s disease virus (MDV) replication but how m6A modifications in ...
Aijun Sun, Xiaojing Zhu, Ying Liu, Rui Wang, Shuaikang Yang, Man Teng, Luping Zheng, Jun Luo, Gaiping Zhang, Guoqing Zhuang   +9 more
doaj   +1 more source

IFNα and IFNγ Impede Marek’s Disease Progression [PDF]

, 2019
Marek’s disease virus (MDV) is an alphaherpesvirus that causes Marek’s disease, a malignant lymphoproliferative disease of domestic chickens. While MDV vaccines protect animals from clinical disease, they do not provide sterilizing immunity and allow ...
Bertzbach, Luca D., Fehler, Frank, Harlin, Olof, Härtle, Sonja, Kaspers, Bernd, Kaufer, Benedikt B., Vychodil, Tereza   +6 more
core   +1 more source

Transcriptional Analysis of Marek's Disease Virus(MDV) Genes in MDV-Transformed Lymphoblastoid Cell Lines without MDV-Activated Cells.

Journal of Veterinary Medical Science, 1998
Spontaneously activated MDV is rarely included in MDV-transformed cells, while it may influence the results of transcriptional analysis. A population consisting of 10(3) MDV-transformed cells probably did not include spontaneously activated MDV, since the estimated frequency of MDV-transformed cells including activated MDV was below 0.01% according to ...
M, Ui, D, Endoh, K O, Cho, Y, Kon, A, Iwata, Y, Maki, F, Sato, M, Kuwabara   +7 more
openaire   +3 more sources

Differential cytokine responses following Marek's disease virus infection in chicken genotypes differing in resistance to Marek's disease [PDF]

, 2003
The production of cytokine mRNAs, in addition to viral DNA, was quantified by real-time quantitative reverse transcription-PCR (RT-PCR) (cytokines) or PCR (virus) in splenocytes during the course of Marek's disease virus (MDV) infection in four inbred ...
Davison, T F, Kaiser, Pete, Underwood, G
core   +1 more source

Effect of Insertion and Deletion in the Meq Protein Encoded by Highly Oncogenic Marek’s Disease Virus on Transactivation Activity and Virulence

Viruses, 2022
Marek’s disease virus (MDV) causes malignant lymphoma in chickens (Marek’s disease, MD). Although MD is currently controlled by vaccination, MDV strains have continuously increased in virulence over the recent decades.
Jumpei Sato, Shiro Murata, Zhiyuan Yang, Benedikt B. Kaufer, Sotaro Fujisawa, Hikari Seo, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Nikolaus Osterrieder, Mark S. Parcells, Kazuhiko Ohashi   +11 more
doaj   +1 more source

In Vivo Inhibition of Marek’s Disease Virus in Transgenic Chickens Expressing Cas9 and gRNA against ICP4

Microorganisms, 2021
Marek’s disease (MD), caused by MD herpesvirus (MDV), is an economically important disease in chickens. The efficacy of the existing vaccines against evolving virulent stains may become limited and necessitates the development of novel antiviral ...
Arjun Challagulla, Kristie A. Jenkins, Terri E. O’Neil, Shunning Shi, Kirsten R. Morris, Terry G. Wise, Prasad N. Paradkar, Mark L. Tizard, Timothy J. Doran, Karel A. Schat   +9 more
doaj   +1 more source

Assembly of Marek's disease virus (MDV) capsids using recombinant baculoviruses expressing MDV capsid proteins

Journal of General Virology, 2004
The genes UL18, UL19, UL26, UL26.5, UL35 and UL38 of Marek's disease virus 1 (MDV-1) strain RB1B, encoding the homologues of herpes simplex virus type 1 (HSV-1) capsid proteins VP23, VP5, VP21–VP24, preVP22a, VP26 and VP19C, were identified and sequenced. Recombinant baculoviruses were used to express the six capsid genes in insect cells.
Kut, Emmanuel, Rasschaert, Denis
openaire   +3 more sources

Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine (PCV13) formulated with 2-phenoxyethanol in multidose vials given with routine vaccination in healthy infants: An open-label randomized controlled trial. [PDF]

, 2017
BACKGROUND: This open-label randomized controlled trial in infants compared safety, tolerability, and immunogenicity of the 13-valent pneumococcal conjugate vaccine (PCV13) formulated with the preservative 2-phenoxyethanol (2-PE) in a multidose vial (MDV)
Ceesay, Bubacarr, Center, Kimberly J, Gurtman, Alejandra, Idoko, Olubukola T, Jansen, Kathrin U, Kampmann, Beate, Laudat, France, Le Dren-Narayanin, Natacha, Liang, John Z, Mboizi, Robert B, Okoye, Michael, Roca, Anna, Scott, Daniel A   +12 more
core   +1 more source

Neuroprotective effects of sinomenine and metformin in diabetic stroke: Role of NLRP3/caspase-1 and mitophagy. [PDF]

Exp Physiol
Abstract Type 2 diabetes mellitus (T2DM) significantly increases the risk and severity of cerebral ischaemia–reperfusion (IR) injury, yet effective neuroprotective treatments for diabetic stroke remain limited. This study explored whether a combination of sinomenine and metformin could offer enhanced neuroprotection in diabetic rats subjected to ...
Li W, Fan Y, Hussain SA.
europepmc   +2 more sources

The Incompressible Euler Limit of the Boltzmann Equation with Accommodation Boundary Condition [PDF]

, 2011
The convergence of solutions of the incompressible Navier-Stokes equations set in a domain with boundary to solutions of the Euler equations in the large Reynolds number limit is a challenging open problem both in 2 and 3 space dimensions.
Bardos, Claude, Golse, François, Paillard, Lionel   +2 more
core   +4 more sources