Results 21 to 30 of about 5,960 (183)

Effect of Insertion and Deletion in the Meq Protein Encoded by Highly Oncogenic Marek’s Disease Virus on Transactivation Activity and Virulence

Viruses, 2022
Marek’s disease virus (MDV) causes malignant lymphoma in chickens (Marek’s disease, MD). Although MD is currently controlled by vaccination, MDV strains have continuously increased in virulence over the recent decades.
Jumpei Sato, Shiro Murata, Zhiyuan Yang, Benedikt B. Kaufer, Sotaro Fujisawa, Hikari Seo, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Nikolaus Osterrieder, Mark S. Parcells, Kazuhiko Ohashi   +11 more
doaj   +1 more source

Transcriptional Analysis of Marek's Disease Virus(MDV) Genes in MDV-Transformed Lymphoblastoid Cell Lines without MDV-Activated Cells.

Journal of Veterinary Medical Science, 1998
Spontaneously activated MDV is rarely included in MDV-transformed cells, while it may influence the results of transcriptional analysis. A population consisting of 10(3) MDV-transformed cells probably did not include spontaneously activated MDV, since the estimated frequency of MDV-transformed cells including activated MDV was below 0.01% according to ...
UI, Masahiro, ENDOH, Daiji, CHO, Kyoung-Oh, KON, Yasuhiro, IWATA, Akira, MAKI, Yoshiyuki, SATO, Fumiaki, KUWABARA, Mikinori   +7 more
openaire   +3 more sources

In Vivo Inhibition of Marek’s Disease Virus in Transgenic Chickens Expressing Cas9 and gRNA against ICP4

Microorganisms, 2021
Marek’s disease (MD), caused by MD herpesvirus (MDV), is an economically important disease in chickens. The efficacy of the existing vaccines against evolving virulent stains may become limited and necessitates the development of novel antiviral ...
Arjun Challagulla, Kristie A. Jenkins, Terri E. O’Neil, Shunning Shi, Kirsten R. Morris, Terry G. Wise, Prasad N. Paradkar, Mark L. Tizard, Timothy J. Doran, Karel A. Schat   +9 more
doaj   +1 more source

The survey on the circulation of Marek’s disease virus in local chickens in Tra Vinh province, Vietnam

Veterinary Integrative Sciences, 2023
The study was conducted to determine the circulation of Marek’s disease virus in local chickens in Tra Vinh province. A total of 343 feather follicle samples were collected from 49 unvaccinated chicken flocks for Marek disease in Tra Vinh City ...
Huynh Ngoc Trang, Nguyen Le Hung Phong, Nguyen Tran Phuoc Chien, Ho Thi Viet Thu   +3 more
doaj   +1 more source

Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion.

PLoS Pathogens, 2019
The cellular DNA sensor cGMP-AMP synthase (cGAS) detects cytosolic viral DNA via the stimulator of interferon genes (STING) to initiate innate antiviral response.
Kai Li, Yongzhen Liu, Zengkun Xu, Yu Zhang, Dan Luo, Yulong Gao, Yingjuan Qian, Chenyi Bao, Changjun Liu, Yanping Zhang, Xiaole Qi, Hongyu Cui, Yongqiang Wang, Li Gao, Xiaomei Wang   +14 more
doaj   +1 more source

Gold(III) Semiquinone Complexes: Synthesis, Structure, and Application in Photocatalysis

Angewandte Chemie, EarlyView.
Au(III) catecholate complexes engage into electron donor acceptor (EDA) interactions with aryldiazonium salts, enabling single‐electron transfer under green light irradiation. Ligand‐centered one‐electron oxidation to stable semi‐quinone complexes provides a new platform for standalone Au(III) photoredox catalysis, as substantiated by the C–H arylation
Miguel A. Gonzálvez, Félix Léon, Vlad Martin‐Diaconescu, Baptiste Martin, Sonia Mallet‐Ladeira, Juan José Gamboa‐Carballo, Karinne Miqueu, György Szalóki, Didier Bourissou   +8 more
wiley   +2 more sources

Assembly of Marek's disease virus (MDV) capsids using recombinant baculoviruses expressing MDV capsid proteins

Journal of General Virology, 2004
The genes UL18, UL19, UL26, UL26.5, UL35 and UL38 of Marek's disease virus 1 (MDV-1) strain RB1B, encoding the homologues of herpes simplex virus type 1 (HSV-1) capsid proteins VP23, VP5, VP21–VP24, preVP22a, VP26 and VP19C, were identified and sequenced. Recombinant baculoviruses were used to express the six capsid genes in insect cells.
Kut, Emmanuel, Rasschaert, Denis
openaire   +3 more sources

Marek's Disease Virus Type 2 (MDV-2)-Encoded MicroRNAs Show No Sequence Conservation with Those Encoded by MDV-1 [PDF]

Journal of Virology, 2007
ABSTRACTMicroRNAs (miRNAs) are increasingly being recognized as major regulators of gene expression in many organisms, including viruses. Among viruses, members of the familyHerpesviridaeaccount for the majority of the currently known virus-encoded miRNAs.
Yao, Y., Zhao, Y., Xu, H., Smith, L. P., Lawrie, C. H., Sewer, A., Zavolan, M., Nair, V.   +7 more
openaire   +3 more sources

Recombinant Marek’s Disease Virus (MDV)-Derived Lymphoblastoid Cell Lines: Regulation of a Marker Gene within the Context of the MDV Genome [PDF]

Journal of Virology, 1999
ABSTRACTMarek’s disease is a herpesvirus (Marek’s disease virus [MDV])-induced pathology of chickens characterized by paralysis and the rapid appearance of T-cell lymphomas. Lymphoblastoid cell lines (LBCLs) derived from MDV-induced tumors have served as models of MDV latency and transformation. We have recently reported the construction of mutant MDVs
M S, Parcells, R L, Dienglewicz, A S, Anderson, R W, Morgan   +3 more
openaire   +2 more sources

First report of Serotype-1 Marek’s disease virus (MDV-1) with oncogenic form in backyard turkeys in Turkey: a molecular analysis study

BMC Veterinary Research, 2022
Background Marek’s disease (MD) is a lymphoproliferative disease caused by Gallid alphaherpesvirus 2 (GaHV-2, MDV-1), which primarily affects chickens. However, the virus is also able to induce tumors and polyneuritis in turkeys, albeit less frequently ...
Hasan Ongor, Necati Timurkaan, Hasan Abayli, Burak Karabulut, Hakan Kalender, Sukru Tonbak, Hatice Eroksuz, Burhan Çetinkaya   +7 more
doaj   +1 more source