Results 31 to 40 of about 6,080 (184)

The survey on the circulation of Marek’s disease virus in local chickens in Tra Vinh province, Vietnam

Veterinary Integrative Sciences, 2023
The study was conducted to determine the circulation of Marek’s disease virus in local chickens in Tra Vinh province. A total of 343 feather follicle samples were collected from 49 unvaccinated chicken flocks for Marek disease in Tra Vinh City ...
Huynh Ngoc Trang, Nguyen Le Hung Phong, Nguyen Tran Phuoc Chien, Ho Thi Viet Thu   +3 more
doaj   +1 more source

Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion.

PLoS Pathogens, 2019
The cellular DNA sensor cGMP-AMP synthase (cGAS) detects cytosolic viral DNA via the stimulator of interferon genes (STING) to initiate innate antiviral response.
Kai Li, Yongzhen Liu, Zengkun Xu, Yu Zhang, Dan Luo, Yulong Gao, Yingjuan Qian, Chenyi Bao, Changjun Liu, Yanping Zhang, Xiaole Qi, Hongyu Cui, Yongqiang Wang, Li Gao, Xiaomei Wang   +14 more
doaj   +1 more source

Recombinant Marek’s Disease Virus (MDV)-Derived Lymphoblastoid Cell Lines: Regulation of a Marker Gene within the Context of the MDV Genome [PDF]

Journal of Virology, 1999
ABSTRACTMarek’s disease is a herpesvirus (Marek’s disease virus [MDV])-induced pathology of chickens characterized by paralysis and the rapid appearance of T-cell lymphomas. Lymphoblastoid cell lines (LBCLs) derived from MDV-induced tumors have served as models of MDV latency and transformation. We have recently reported the construction of mutant MDVs
M S, Parcells, R L, Dienglewicz, A S, Anderson, R W, Morgan   +3 more
openaire   +2 more sources

Assembly of Marek's disease virus (MDV) capsids using recombinant baculoviruses expressing MDV capsid proteins

Journal of General Virology, 2004
The genes UL18, UL19, UL26, UL26.5, UL35 and UL38 of Marek's disease virus 1 (MDV-1) strain RB1B, encoding the homologues of herpes simplex virus type 1 (HSV-1) capsid proteins VP23, VP5, VP21–VP24, preVP22a, VP26 and VP19C, were identified and sequenced. Recombinant baculoviruses were used to express the six capsid genes in insect cells.
Kut, Emmanuel, Rasschaert, Denis
openaire   +3 more sources

Marek’s Disease Virus Cluster 3 miRNAs Restrict Virus’ Early Cytolytic Replication and Pathogenesis

Viruses, 2020
Herpesvirus-encoded microRNAs (miRNAs) have been discovered in infected cells; however, lack of a suitable animal model has hampered functional analyses of viral miRNAs in vivo.
Yifei Liao, Guoqing Zhuang, Aijun Sun, Owais A. Khan, Blanca Lupiani, Sanjay M. Reddy   +5 more
doaj   +1 more source

Diversity (Polymorphism) of the meq Gene in the Attenuated Marek's Disease Virus (MDV) Serotype 1 and MDV-Transformed Cell Lines.

Journal of Veterinary Medical Science, 2002
The meq gene encoding a 339-amino-acid bZIP transactivator protein has been identified as a candidate oncogene of Marek's disease virus serotype 1 (MDV1), which induces malignant lymphomas in chickens. We have previously reported that, in addition to meq, L-meq, in which a 180-bp sequence is inserted into the region encoding the transactivation domain ...
CHANG, Kyung-Soo, OHASHI, Kazuhiko, ONUMA, Misao   +2 more
openaire   +3 more sources

First report of Serotype-1 Marek’s disease virus (MDV-1) with oncogenic form in backyard turkeys in Turkey: a molecular analysis study

BMC Veterinary Research, 2022
Background Marek’s disease (MD) is a lymphoproliferative disease caused by Gallid alphaherpesvirus 2 (GaHV-2, MDV-1), which primarily affects chickens. However, the virus is also able to induce tumors and polyneuritis in turkeys, albeit less frequently ...
Hasan Ongor, Necati Timurkaan, Hasan Abayli, Burak Karabulut, Hakan Kalender, Sukru Tonbak, Hatice Eroksuz, Burhan Çetinkaya   +7 more
doaj   +1 more source

Metabolomic profiling of Marek’s disease virus infection in host cell based on untargeted LC-MS

Frontiers in Microbiology, 2023
Marek’s disease (MD) caused by Marek’s disease virus (MDV), poses a serious threat to the poultry industry by inducing neurological disease and malignant lymphoma in infected chickens.
Qingsen Wang, Qingsen Wang, Qingsen Wang, Bin Shi, Bin Shi, Bin Shi, Guifu Yang, Guifu Yang, Guifu Yang, Xueying Zhu, Xueying Zhu, Xueying Zhu, Hongxia Shao, Hongxia Shao, Hongxia Shao, Kun Qian, Kun Qian, Kun Qian, Jianqiang Ye, Jianqiang Ye, Jianqiang Ye, Aijian Qin, Aijian Qin, Aijian Qin   +23 more
doaj   +1 more source

The Requirement of Glycoprotein C for Interindividual Spread Is Functionally Conserved within the Alphaherpesvirus Genus (Mardivirus), but Not the Host (Gallid)

Viruses, 2021
Marek’s disease (MD) in chickens is caused by Gallid alphaherpesvirus 2, better known as MD herpesvirus (MDV). Current vaccines do not block interindividual spread from chicken-to-chicken, therefore, understanding MDV interindividual spread provides ...
Widaliz Vega-Rodriguez, Nagendraprabhu Ponnuraj, Maricarmen Garcia, Keith W. Jarosinski   +3 more
doaj   +1 more source

Role of Marek’s Disease Virus (MDV)-Encoded U _S 3 Serine/Threonine Protein Kinase in Regulating MDV Meq and Cellular CREB Phosphorylation [PDF]

Journal of Virology, 2020
MDV is a potent oncogenic herpesvirus that induces T-cell lymphoma in infected chickens. Marek's disease continues to have a significant economic impact on the poultry industry worldwide. U S 3 encoded by alphaherpesviruses is a multifunctional kinase involved in the regulation of various cellular pathways. Using an
Liao, Yifei, Lupiani, Blanca, Bajwa, Kanika, Khan, Owais A, Izumiya, Yoshihiro, Reddy, Sanjay M   +5 more
openaire   +4 more sources