Results 31 to 40 of about 10,431 (233)

Marek's Disease Virus Type 2 (MDV-2)-Encoded MicroRNAs Show No Sequence Conservation with Those Encoded by MDV-1 [PDF]

Journal of Virology, 2007
ABSTRACTMicroRNAs (miRNAs) are increasingly being recognized as major regulators of gene expression in many organisms, including viruses. Among viruses, members of the familyHerpesviridaeaccount for the majority of the currently known virus-encoded miRNAs.
Yong-Xiu Yao, Yu-Guang Zhao, Hong-Tao Xu, Lorraine P. Smith, C. Lawrie, A. Sewer, M. Zavolan, V. Nair   +7 more
semanticscholar   +4 more sources

Transcriptome-wide N6-methyladenosine modification profiling of long non-coding RNAs during replication of Marek’s disease virus in vitro

BMC Genomics, 2021
Background The newly discovered reversible N6-methyladenosine (m6A) modification plays an important regulatory role in gene expression. Long non-coding RNAs (lncRNAs) participate in Marek’s disease virus (MDV) replication but how m6A modifications in ...
Aijun Sun, Xiaojing Zhu, Ying Liu, Rui Wang, Shuaikang Yang, Man Teng, Luping Zheng, Jun Luo, Gaiping Zhang, Guoqing Zhuang   +9 more
doaj   +1 more source

Transcriptional Analysis of Marek's Disease Virus(MDV) Genes in MDV-Transformed Lymphoblastoid Cell Lines without MDV-Activated Cells.

Journal of Veterinary Medical Science, 1998
Spontaneously activated MDV is rarely included in MDV-transformed cells, while it may influence the results of transcriptional analysis. A population consisting of 10(3) MDV-transformed cells probably did not include spontaneously activated MDV, since the estimated frequency of MDV-transformed cells including activated MDV was below 0.01% according to ...
UI, Masahiro, ENDOH, Daiji, CHO, Kyoung-Oh, KON, Yasuhiro, IWATA, Akira, MAKI, Yoshiyuki, SATO, Fumiaki, KUWABARA, Mikinori   +7 more
openaire   +3 more sources

The Marek's disease virus (MDV) unique short region: alphaherpesvirus-homologous, fowlpox virus-homologous, and MDV-specific genes.

Virology, 1995
Despite its previous classification as a gammaherpesvirus, primarily due to its lymphotropism, Marek's disease virus (MDV), an oncogenic avian herpesvirus, is phylogenetically more related to the "neurotropic" alphaherpesviruses, characterized by its prototype, herpes simplex virus (HSV) (Buckmaster et al., 1988, J. Gen. Virol. 69, 2033-2042).
P. Brunovskis, L. F. Velicer
semanticscholar   +3 more sources

The survey on the circulation of Marek’s disease virus in local chickens in Tra Vinh province, Vietnam

Veterinary Integrative Sciences, 2023
The study was conducted to determine the circulation of Marek’s disease virus in local chickens in Tra Vinh province. A total of 343 feather follicle samples were collected from 49 unvaccinated chicken flocks for Marek disease in Tra Vinh City ...
Huynh Ngoc Trang, Nguyen Le Hung Phong, Nguyen Tran Phuoc Chien, Ho Thi Viet Thu   +3 more
doaj   +1 more source

Effect of gga-miR-155 on cell proliferation, apoptosis and invasion of Marek’s disease virus (MDV) transformed cell line MSB1 by targeting RORA

BMC Veterinary Research, 2019
Background Marek’s disease (MD) is caused by the oncogenic Marek’s disease virus (MDV), and is a highly contagious avian infection with a complex underlying pathology that involves lymphoproliferative neoplasm formation.
K. Ding, Zu-Hua Yu, Chuan Yu, Yan-Yan Jia, Lei He, Cheng-Shui Liao, Jing Li, Chunjie Zhang, Yinju Li, Tingcai Wu, Xiangchao Cheng, Zi-Yu Zhou, Zu-Ling Yu   +12 more
semanticscholar   +1 more source

Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization

PLoS Pathogens, 2018
Codon pair bias deoptimization (CPBD) has enabled highly efficient and rapid attenuation of RNA viruses. The technique relies on recoding of viral genes by increasing the number of codon pairs that are statistically underrepresented in protein coding ...
K. Eschke, J. Trimpert, N. Osterrieder, Dusan Kunec   +3 more
semanticscholar   +1 more source

Application of CRISPR/Cas9 Gene Editing System on MDV-1 Genome for the Study of Gene Function

Viruses, 2018
Marek’s disease virus (MDV) is a member of alphaherpesviruses associated with Marek’s disease, a highly contagious neoplastic disease in chickens. Complete sequencing of the viral genome and recombineering techniques using infectious bacterial artificial
Yaoyao Zhang, N. Tang, Y. Sadigh, S. Baigent, Zhiqiang Shen, V. Nair, Yong-Xiu Yao   +6 more
semanticscholar   +1 more source

Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion.

PLoS Pathogens, 2019
The cellular DNA sensor cGMP-AMP synthase (cGAS) detects cytosolic viral DNA via the stimulator of interferon genes (STING) to initiate innate antiviral response.
Kai Li, Yongzhen Liu, Zengkun Xu, Yu Zhang, Dan Luo, Yulong Gao, Yingjuan Qian, Chenyi Bao, Changjun Liu, Yanping Zhang, Xiaole Qi, Hongyu Cui, Yongqiang Wang, Li Gao, Xiaomei Wang   +14 more
doaj   +1 more source

Effect of Insertion and Deletion in the Meq Protein Encoded by Highly Oncogenic Marek’s Disease Virus on Transactivation Activity and Virulence

Viruses, 2022
Marek’s disease virus (MDV) causes malignant lymphoma in chickens (Marek’s disease, MD). Although MD is currently controlled by vaccination, MDV strains have continuously increased in virulence over the recent decades.
Jumpei Sato, Shiro Murata, Zhiyuan Yang, Benedikt B. Kaufer, Sotaro Fujisawa, Hikari Seo, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Nikolaus Osterrieder, Mark S. Parcells, Kazuhiko Ohashi   +11 more
doaj   +1 more source