Trials for isolation and identification of Marek's disease virus (MDV) in layer chicken farms vaccinated with MDV vaccines exhibiting MDV-like symptoms in Egypt [PDF]
Benha Veterinary Medical JournalMarek's disease virus (MDV) is a lymphoproliferative neuropathic disease affecting domestic fowl. Despite intensive vaccination, Egyptian poultry farms continue to experience recurrent infections of MDV.
Alaa H. Ibrahim +3 more
doaj +2 more sources
Role of Marek’s Disease Virus (MDV)-Encoded US3 Serine/Threonine Protein Kinase in Regulating MDV Meq and Cellular CREB Phosphorylation [PDF]
Journal of Virology, 2020 MDV is a potent oncogenic herpesvirus that induces T-cell lymphoma in infected chickens. Marek's disease continues to have a significant economic impact on the poultry industry worldwide.
Yi-Fei Liao +5 more
semanticscholar +5 more sources
Proteomic Analysis Reveals AMPKα-Mediated Antiandrogen Resistance via Ferroptosis Suppression in Prostate Cancer. [PDF]
Cancer SciAntiandrogen‐resistant prostate cancer cells acquire ferroptosis resistance through AMPKα activation and upregulation of ferroptosis suppressor pathways. This adaptive state creates a therapeutic vulnerability, as GPX4 inhibition, particularly in combination with AMPKα inhibition, effectively suppresses the growth of resistant cells.
Shiota M +8 more
europepmc +2 more sources
Viruses, 2021 Marek’s disease virus (MDV) is an oncogenic avian alphaherpesvirus whose genome consists of unique long (UL) and short (US) regions that are flanked by inverted repeat regions.
Yifei Liao +2 more
doaj +1 more source
Alterations of the MDV oncogenic regions in an MDV transformed lymphoblastoid cell line [PDF]
Molecular Pathology, 2002 Lymphoblastoid cell lines derived from Marek's disease virus (MDV) induced tumours have served as models of MDV latency and transformation. They are stable and can be cultured with no detectable MDV genomic alterations upon repeated passaging. An MDV transformed lymphoblastoid T cell line (T9 cell line) has been reported to contain a disrupted MDV ...
Le Rouzic, E. +5 more
openaire +3 more sources
Vitamin Compatibility with the Marek’s Disease Vaccine
Poultry, 2023 In ovo injection of the Marek’s disease (MD) vaccine (MDV) has been widely practiced in commercial US hatcheries. However, the MDV is very sensitive and may not be compatible with some nutrients when administered together by in ovo injection.
Seyed Abolghasem Fatemi +3 more
doaj +1 more source
Participatory Communication and Mass Dog Vaccination for Effective Rabies Management in Mitooma District, Western Uganda: An Exploratory Study. [PDF]
Public Health ChallThis study evaluates participatory communication strategies in mass dog vaccination campaigns within Mitooma District. By actively engaging local communities, the initiative significantly enhanced vaccination coverage, improved public awareness of rabies prevention, and established a scalable, community‐driven framework for effective zoonotic disease ...
Ngabirano A, Igwe MC, Idehen C.
europepmc +2 more sources
Microorganisms, 2021 Promyelocytic leukemia protein nuclear bodies (PML-NBs) are dynamic nuclear structures, shown to be important for herpesvirus replication; however, their role in regulating Marek’s disease virus (MDV) infection has not been studied.
Yifei Liao +2 more
doaj +1 more source
MDVs: Spare the SOD and Spoil the Bug [PDF]
Cell Host & Microbe, 2018 Mitochondrial reactive oxygen species are important anti-microbial weapons utilized by phagocytes of the innate immune system. In this issue of Cell Host and Microbe, Abuaita et al. (2018) show that in macrophages, mitochondrial-derived vesicles deliver the superoxide dismutase Sod2 to bacteria-containing phagosomes to produce hydrogen peroxide and ...
Syed Saad, Hussain, David F, Kashatus
openaire +2 more sources
The Emergence of a vv + MDV Can Break through the Protections Provided by the Current Vaccines
Viruses, 2020 Marek’s disease (MD) is an infectious malignant T-cell lymphoma proliferative disease caused by Marek’s disease virus (MDV). In recent years, the emergence of very virulent (vv) and/or very virulent plus (vv +) strains of MDV in the field has been ...
M. Shi +8 more
semanticscholar +1 more source