Results 41 to 50 of about 10,431 (233)

Induction of the unfolded protein response (UPR) during Marek's disease virus (MDV) infection.

Virology, 2018
Marek's disease (MD) is a pathology of chickens associated with paralysis, immune suppression, and the rapid formation of T-cell lymphomas. MD is caused by the herpesvirus, Marek's disease virus (MDV).
S. Neerukonda, U. Katneni, M. Bott, S. Golovan, M. Parcells   +4 more
semanticscholar   +1 more source

Recombinant Marek’s Disease Virus (MDV)-Derived Lymphoblastoid Cell Lines: Regulation of a Marker Gene within the Context of the MDV Genome [PDF]

Journal of Virology, 1999
ABSTRACTMarek’s disease is a herpesvirus (Marek’s disease virus [MDV])-induced pathology of chickens characterized by paralysis and the rapid appearance of T-cell lymphomas. Lymphoblastoid cell lines (LBCLs) derived from MDV-induced tumors have served as models of MDV latency and transformation. We have recently reported the construction of mutant MDVs
M S, Parcells, R L, Dienglewicz, A S, Anderson, R W, Morgan   +3 more
openaire   +2 more sources

In Vivo Inhibition of Marek’s Disease Virus in Transgenic Chickens Expressing Cas9 and gRNA against ICP4

Microorganisms, 2021
Marek’s disease (MD), caused by MD herpesvirus (MDV), is an economically important disease in chickens. The efficacy of the existing vaccines against evolving virulent stains may become limited and necessitates the development of novel antiviral ...
Arjun Challagulla, Kristie A. Jenkins, Terri E. O’Neil, Shunning Shi, Kirsten R. Morris, Terry G. Wise, Prasad N. Paradkar, Mark L. Tizard, Timothy J. Doran, Karel A. Schat   +9 more
doaj   +1 more source

Identification of the Receptor and Cellular Ortholog of the Marek's Disease Virus (MDV) CXC Chemokine

Frontiers in Microbiology, 2017
Marek's disease virus (MDV) is a cell associated alphaherpesvirus that causes fatal lymphoma in chickens. One factor that plays a crucial role in MDV pathogenesis is the viral CXC chemokine vIL-8 that was originally named after chicken interleukin 8 (cIL-
Sonja Haertle, I. Alzuheir, Florian Busalt, V. Waters, P. Kaiser, B. Kaufer   +5 more
semanticscholar   +1 more source

Assembly of Marek's disease virus (MDV) capsids using recombinant baculoviruses expressing MDV capsid proteins

Journal of General Virology, 2004
The genes UL18, UL19, UL26, UL26.5, UL35 and UL38 of Marek's disease virus 1 (MDV-1) strain RB1B, encoding the homologues of herpes simplex virus type 1 (HSV-1) capsid proteins VP23, VP5, VP21–VP24, preVP22a, VP26 and VP19C, were identified and sequenced. Recombinant baculoviruses were used to express the six capsid genes in insect cells.
Kut, Emmanuel, Rasschaert, Denis
openaire   +3 more sources

Metabolomic profiling of Marek’s disease virus infection in host cell based on untargeted LC-MS

Frontiers in Microbiology, 2023
Marek’s disease (MD) caused by Marek’s disease virus (MDV), poses a serious threat to the poultry industry by inducing neurological disease and malignant lymphoma in infected chickens.
Qingsen Wang, Qingsen Wang, Qingsen Wang, Bin Shi, Bin Shi, Bin Shi, Guifu Yang, Guifu Yang, Guifu Yang, Xueying Zhu, Xueying Zhu, Xueying Zhu, Hongxia Shao, Hongxia Shao, Hongxia Shao, Kun Qian, Kun Qian, Kun Qian, Jianqiang Ye, Jianqiang Ye, Jianqiang Ye, Aijian Qin, Aijian Qin, Aijian Qin   +23 more
doaj   +1 more source

Marek’s Disease Virus Modulates T Cell Proliferation via Activation of Cyclooxygenase 2-Dependent Prostaglandin E2

Frontiers in Immunology, 2021
Marek’s disease virus (MDV), an avian alphaherpesvirus, infects chickens, transforms CD4+ T cells, and induces immunosuppression early during infection.
Nitin Kamble, Angila Gurung, Angila Gurung, Benedikt B. Kaufer, Ansar Ahmed Pathan, Shahriar Behboudi, Shahriar Behboudi   +6 more
doaj   +1 more source

Marek’s Disease Virus Cluster 3 miRNAs Restrict Virus’ Early Cytolytic Replication and Pathogenesis

Viruses, 2020
Herpesvirus-encoded microRNAs (miRNAs) have been discovered in infected cells; however, lack of a suitable animal model has hampered functional analyses of viral miRNAs in vivo.
Yifei Liao, Guoqing Zhuang, Aijun Sun, Owais A. Khan, Blanca Lupiani, Sanjay M. Reddy   +5 more
doaj   +1 more source

Histone modifications induced by MDV infection at early cytolytic and latency phases

BMC Genomics, 2015
BackgroundMarek’s disease (MD) is a highly contagious, lymphomatous disease of chickens induced by a herpesvirus, Marek’s disease virus (MDV) that is the cause of major annual losses to the poultry industry.
Apratim Mitra, Juan Luo, Yang-Hua He, Yu-Lan Gu, Huan-Ming Zhang, Ke-Ji Zhao, Kai-Rong Cui, Jiuzhou Song   +7 more
semanticscholar   +1 more source

Diversity (Polymorphism) of the meq Gene in the Attenuated Marek's Disease Virus (MDV) Serotype 1 and MDV-Transformed Cell Lines.

Journal of Veterinary Medical Science, 2002
The meq gene encoding a 339-amino-acid bZIP transactivator protein has been identified as a candidate oncogene of Marek's disease virus serotype 1 (MDV1), which induces malignant lymphomas in chickens. We have previously reported that, in addition to meq, L-meq, in which a 180-bp sequence is inserted into the region encoding the transactivation domain ...
CHANG, Kyung-Soo, OHASHI, Kazuhiko, ONUMA, Misao   +2 more
openaire   +3 more sources